CREB1 and CAMK2A

Number of citations of the paper that reports this interaction (PMID 8663317)
9

Data Source:
BioGRID (enzymatic study)

		CREB1	CAMK2A
Gene Name		cAMP responsive element binding protein 1	calcium/calmodulin-dependent protein kinase II alpha
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Euchromatin ATF1-ATF4 Transcription Factor Complex	Nucleus Nucleoplasm Mitochondrion Cytosol Plasma Membrane Cell Junction Endocytic Vesicle Membrane Presynaptic Membrane
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Cofactor Activity Protein Binding Enzyme Binding CAMP Response Element Binding	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Glutamate Receptor Binding Protein Homodimerization Activity
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription From RNA Polymerase II Promoter Protein Phosphorylation Organelle Organization Mitochondrion Organization Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Notch Signaling Pathway Synaptic Transmission Axon Guidance Lactation Memory Circadian Rhythm Regulation Of Cell Size Fibroblast Growth Factor Receptor Signaling Pathway Response To Organic Substance Negative Regulation Of Transcription By Competitive Promoter Binding Viral Process Pituitary Gland Development Secretory Granule Organization Response To Glucagon Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of Multicellular Organism Growth Response To Drug Innate Immune Response Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Hormone Secretion Positive Regulation Of Lipid Biosynthetic Process Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Protein Stabilization Stress-activated MAPK Cascade Lung Saccule Development Type I Pneumocyte Differentiation Cellular Response To Zinc Ion	G1/S Transition Of Mitotic Cell Cycle Response To Ischemia Protein Phosphorylation Calcium Ion Transport Synaptic Transmission Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Peptidyl-serine Phosphorylation Cytokine-mediated Signaling Pathway Cellular Response To Heat Protein Autophosphorylation Regulation Of Neurotransmitter Secretion Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Calcium Ion Transport Interferon-gamma-mediated Signaling Pathway Regulation Of Cellular Response To Heat Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Pathways		Signaling by the B Cell Receptor (BCR) Ca-dependent events Signaling by GPCR CaM pathway Phospholipase C-mediated cascade Signaling by FGFR in disease Signaling by EGFRvIII in Cancer CREB phosphorylation through the activation of Ras PLCG1 events in ERBB2 signaling NOTCH2 intracellular domain regulates transcription Signaling by SCF-KIT Toll Like Receptor TLR1:TLR2 Cascade Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling Signaling by NOTCH2 PI3K/AKT activation Toll Like Receptor 5 (TLR5) Cascade PI-3K cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Signaling by PDGF Calmodulin induced events CaMK IV-mediated phosphorylation of CREB DAP12 interactions PKA-mediated phosphorylation of CREB GAB1 signalosome Signaling by NOTCH TRIF-mediated TLR3/TLR4 signaling Opioid Signalling Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling CREB phosphorylation through the activation of Adenylate Cyclase EGFR interacts with phospholipase C-gamma CaMK IV-mediated phosphorylation of CREB Toll Like Receptor 2 (TLR2) Cascade Signaling by ERBB2 PKA-mediated phosphorylation of CREB Signaling by EGFR CREB phosphorylation through the activation of CaMKK AKT phosphorylates targets in the nucleus Calmodulin induced events Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Downstream signal transduction CREB phosphorylation through the activation of CaMKII Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling PI3K/AKT Signaling in Cancer Transcriptional activation of mitochondrial biogenesis Transmission across Chemical Synapses Adaptive Immune System Organelle biogenesis and maintenance CREB phosphorylation Axon guidance PIP3 activates AKT signaling Toll Like Receptor 7/8 (TLR7/8) Cascade CREB phosphorylation DAG and IP3 signaling Toll Like Receptor TLR6:TLR2 Cascade CaM pathway Activated TLR4 signalling MyD88 cascade initiated on plasma membrane PI3K events in ERBB2 signaling Activation of NMDA receptor upon glutamate binding and postsynaptic events Downstream signaling of activated FGFR MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth Post NMDA receptor activation events Innate Immune System Signalling by NGF PLC beta mediated events MAP kinase activation in TLR cascade Signaling by Ligand-Responsive EGFR Variants in Cancer G-protein mediated events NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Signaling by Overexpressed Wild-Type EGFR in Cancer Mitochondrial biogenesis Signaling by FGFR Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade PLC-gamma1 signalling MAPK targets/ Nuclear events mediated by MAP kinases Nuclear Events (kinase and transcription factor activation)	Interferon Signaling Cytokine Signaling in Immune system Cellular response to heat stress Signaling by Wnt CREB phosphorylation through the activation of Ras Trafficking of AMPA receptors beta-catenin independent WNT signaling Interferon gamma signaling HSF1-dependent transactivation Ca2+ pathway Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Unblocking of NMDA receptor, glutamate binding and activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs		Adenosine monophosphate Naloxone
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		75 interactors: ABL1 AKT1 ATF1 ATF6 ATF7IP ATM ATR C14orf1 CAMK2A CCDC6 CEBPB CHD3 CHD8 CREBBP CREM CRTC1 DYRK1A EDF1 EP300 FHL5 GLI2 GSK3A GSK3B GTF2A1 GTF2F2 HIPK3 HNF1B HPS6 KAT5 KCNIP3 KIAA2026 MAPK14 MAPKAPK2 MTF2 MYC NR3C1 PDX1 PIAS1 POGZ POU2F1 PPP1CA PRKACA PRKG1 RAB1A RBBP4 RECQL5 RFX3 RGS13 RNF111 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA4 RPS6KA5 SGK1 SMARCA4 SMARCA5 SOX9 SRA1 SREBF2 SRF SUZ12 THRA TOX4 TRIM22 TSSK4 UBE2I VIM YY1 ZHX1 ZMYM2 ZNF35 ZNF436 ZNF451 ZNF92	40 interactors: ACTN1 ACTN2 ACTN4 ATF1 ATP2A2 CAMK2N2 CDK5R1 CDK5R2 CEBPB CHAT CREB1 DAPK2 DLG1 EGFR ETS1 GFAP GRIN1 GRIN2A GRIN2B HSF1 ITGA2B ITGB1BP1 ITPKA KRT18 LRRC7 MAPT MPDZ NOS1 PDC PPM1F PSMC5 PTTG1 RCHY1 RIMS1 SMAD2 SQSTM1 SRF SYNGAP1 TANC1 YWHAB
Entrez ID		1385	815
HPRD ID		00442	06532
Ensembl ID		ENSG00000118260	ENSG00000070808
Uniprot IDs		P16220 Q53X93 Q5U0J5	A8K161 Q7LDD5 Q8IWE0 Q9UQM7
PDB IDs		2LXT	2VZ6 3SOA
Enriched GO Terms of Interacting Partners?		Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Gene Expression Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Biosynthetic Process RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Peptidyl-serine Phosphorylation Negative Regulation Of Gene Expression Regulation Of Cellular Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Response To Organic Substance Cellular Response To Stress Cellular Response To Organic Substance Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromosome Organization Chromatin Modification Chromatin Organization Response To Stress Regulation Of Signaling Peptidyl-amino Acid Modification Regulation Of Cellular Response To Heat Organelle Organization Cell Differentiation Transcription From RNA Polymerase II Promoter	Regulation Of Synaptic Transmission Cell Projection Organization Neurogenesis Nervous System Development Anatomical Structure Development Generation Of Neurons Cell Differentiation Developmental Process Response To Stimulus Regulation Of Synaptic Plasticity Neuron Projection Development Regulation Of Apoptotic Process Locomotion Regulation Of Cell Death Neuron Differentiation Regulation Of Signaling Regulation Of Cellular Process Neuron Development Single-organism Behavior Regulation Of Cellular Component Organization Positive Regulation Of Cellular Metabolic Process Cell Communication Pons Maturation Movement Of Cell Or Subcellular Component Regulation Of Metabolic Process Positive Regulation Of Gene Expression System Development Positive Regulation Of Metabolic Process Learning Or Memory Cellular Response To Stimulus Signaling Cognition Behavior Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Stress Anatomical Structure Morphogenesis Response To External Stimulus Positive Regulation Of Transcription, DNA-templated Multicellular Organismal Development Response To Abiotic Stimulus Learning Regulation Of Cellular Component Movement Response To Wounding Axonogenesis Regulation Of Neuron Projection Development Cell Morphogenesis Involved In Differentiation Positive Regulation Of Transport Axon Guidance Axon Development Regulation Of Membrane Potential
Tagcloud ?		aao acting allelic chemokine citrate emerged enrichment exceeded fact fdr fdraao fdrmsss gwas hubs influencing italian leukocyte msss network networks nominally ppms sclerosis severity snps tca trait traits transendothelial	acquiring ca1 collecting combines conditioning crossing doxycycline egfp enables epitope fear identities integrates introduce l10a offspring pyramidal ribosomal ribosome ribosomes spiny striatum tagged teto tetracycline transactivator transgene translating tta
Tagcloud (Difference) ?		aao acting allelic chemokine citrate emerged enrichment exceeded fact fdr fdraao fdrmsss gwas hubs influencing italian leukocyte msss network networks nominally ppms sclerosis severity snps tca trait traits transendothelial	acquiring ca1 collecting combines conditioning crossing doxycycline egfp enables epitope fear identities integrates introduce l10a offspring pyramidal ribosomal ribosome ribosomes spiny striatum tagged teto tetracycline transactivator transgene translating tta
Tagcloud (Intersection) ?