CREB1 and CCDC6

Number of citations of the paper that reports this interaction (PubMedID 20498639)
0

Data Source:
BioGRID (enzymatic study)

		CREB1	CCDC6
Description		cAMP responsive element binding protein 1	coiled-coil domain containing 6
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Euchromatin Nucleus Nucleoplasm Transcription Regulator Complex Mitochondrial Matrix Centrosome Cytosol Axon Ciliary Basal Body RNA Polymerase II Transcription Regulator Complex ATF4-CREB1 Transcription Factor Complex	Cytoplasm Cytosol Cytoskeleton
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Enzyme Binding Hsp70 Protein Binding Histone Acetyltransferase Binding CAMP Response Element Binding Identical Protein Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Arrestin Family Protein Binding Sequence-specific Double-stranded DNA Binding	Structural Constituent Of Cytoskeleton Protein Binding SH3 Domain Binding Identical Protein Binding
	Biological Process	Response To Hypoxia Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Protein Phosphorylation Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Axonogenesis Lactation Memory Circadian Rhythm Regulation Of Cell Size Visual Learning Response To Xenobiotic Stimulus Negative Regulation Of Gene Expression Negative Regulation Of Transcription By Competitive Promoter Binding Response To Purine-containing Compound Response To Activity Pituitary Gland Development Cell Differentiation Osteoclast Differentiation Mammary Gland Development Positive Regulation Of Transforming Growth Factor Beta3 Production Secretory Granule Organization Response To Glucagon Chemotaxis To Arachidonate Response To Nicotine Cellular Response To Hepatocyte Growth Factor Stimulus Response To Erythropoietin Cellular Response To Platelet-derived Growth Factor Stimulus Positive Regulation Of Multicellular Organism Growth Response To Cocaine MRNA Transcription By RNA Polymerase II Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Response To Morphine Response To Ethanol Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of Transcription By RNA Polymerase II Hormone Secretion Positive Regulation Of Hormone Secretion Positive Regulation Of Lipid Biosynthetic Process Regulation Of Fibroblast Proliferation Rhythmic Process Protein Stabilization Positive Regulation Of Cardiac Muscle Tissue Development Regulation Of Glial Cell Proliferation Lung Epithelium Development Lung Saccule Development Type I Pneumocyte Differentiation Cellular Response To Zinc Ion Cellular Response To Retinoic Acid Cellular Response To Growth Factor Stimulus Cellular Response To Fatty Acid Cellular Response To Transforming Growth Factor Beta Stimulus CAMP/PKA Signal Transduction Positive Regulation Of Long-term Synaptic Potentiation Response To L-glutamate Response To Dehydroepiandrosterone Positive Regulation Of Membrane Depolarization Cellular Response To Forskolin Cellular Response To Nerve Growth Factor Stimulus Cellular Response To Insulin-like Growth Factor Stimulus Cellular Response To Leukemia Inhibitory Factor Response To Hypobaric Hypoxia Regulation Of Testosterone Biosynthetic Process	Cytoskeleton Organization
Pathways
Drugs		Adenosine phosphate Naloxone
Diseases			Thyroid cancer
GWAS		Body mass index ( 25673413 28892062) Diastolic blood pressure ( 27841878) Food antigen IgG levels ( 24962563) Mean corpuscular hemoglobin ( 32888494) Refractive error ( 32231278) Systolic blood pressure ( 27841878)	Alopecia areata ( 25608926) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878)
Interacting Genes		86 interacting genes: ABL1 AGR2 AKT1 ATF1 ATF6 ATF7IP ATM ATR BRD10 CAMK2A CCDC6 CDK1 CEBPB CHD3 CHD8 CREBBP CREM CRTC1 CRTC2 CSNK1D CSNK2A1 CSNK2B DNMT3L DYRK1A EDF1 ERG28 ETS1 FHL5 GLI2 GSK3A GSK3B GTF2A1 GTF2F2 HIPK3 HIVEP1 HNF1B HPS6 KAT5 KCNIP3 MAPK14 MAPKAPK2 MTF2 NR3C1 PDX1 PIAS1 PIAS2 POGZ POU2F1 PPP1CA PRKACA PRKG1 PTEN RAB1A RBBP4 RECQL5 RFX3 RGS13 RNF111 RNF4 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA4 RPS6KA5 SGK1 SMARCA4 SMARCA5 SMCO1 SOX9 SRA1 SREBF2 SRF SUZ12 THRA TOX4 TRIM22 TSSK4 UBE2I VIM YY1 ZHX1 ZMYM2 ZNF35 ZNF436 ZNF451 ZNF92	31 interacting genes: ATF2 ATF5 CCDC136 CCDC33 CREB1 CSNK2A1 CYTH4 DRC4 DSCR9 FBXW7 LHX3 LRSAM1 LUZP4 MAPK3 MAPK7 MEOX2 PAX6 PIN1 PPP4C SH3RF1 SNAPC1 SORBS3 TFIP11 TRIM14 UBE2I WAC ZNF250 ZNF354C ZNF620 ZNF774 ZNF835
Entrez ID		1385	8030
HPRD ID		00442	09064
Ensembl ID		ENSG00000118260	ENSG00000108091
Uniprot IDs		B7Z5C6 P16220 Q53X93 Q5U0J5	Q05CP8 Q16204
PDB IDs		2LXT 5ZK1 5ZKO 7TBH
Enriched GO Terms of Interacting Partners?		Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Nucleoplasm Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein Serine/threonine Kinase Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Serine Kinase Activity Protein Kinase Activity PML Body Kinase Activity Chromatin DNA Binding Negative Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation ATP Binding Transferase Activity Chromatin Remodeling Phosphorylation Cellular Response To Oxygen-containing Compound Cellular Response To Stress Positive Regulation Of CREB Transcription Factor Activity DNA-binding Transcription Factor Activity Chromatin Organization Sequence-specific DNA Binding Nucleic Acid Metabolic Process Intracellular Signal Transduction	Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Nucleus Phosphothreonine Residue Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Sequence-specific DNA Binding Positive Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of DNA-templated Transcription Regulation Of Ubiquitin-dependent Protein Catabolic Process Pituitary Gland Development Regulation Of Macromolecule Biosynthetic Process Regulation Of Macroautophagy Positive Regulation Of Macroautophagy Regulation Of Proteasomal Protein Catabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Catabolic Process MAPK Cascade Transcription Coregulator Binding Protein Stabilization Positive Regulation Of Xenophagy Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Gland Development Negative Regulation Of Proteolysis Signal Transduction In Response To DNA Damage DNA Binding CAMP Response Element Binding Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Autophagy MAP Kinase Activity Positive Regulation Of Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA Damage Response Positive Regulation Of Catabolic Process Positive Regulation Of Macromolecule Metabolic Process
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