CREB1 and RPS6KA1

Number of citations of the paper that reports this interaction (PubMedID 9687510)
44

Data Source:
HPRD (in vitro)

		CREB1	RPS6KA1
Description		cAMP responsive element binding protein 1	ribosomal protein S6 kinase A1
Image
GO Annotations	Cellular Component	Chromatin Euchromatin Nucleus Nucleoplasm Transcription Regulator Complex Mitochondrial Matrix Centrosome Cytosol Axon Ciliary Basal Body RNA Polymerase II Transcription Regulator Complex ATF4-CREB1 Transcription Factor Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Synapse
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Enzyme Binding Hsp70 Protein Binding Histone Acetyltransferase Binding CAMP Response Element Binding Identical Protein Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Arrestin Family Protein Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Response To Hypoxia Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Protein Phosphorylation Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Axonogenesis Lactation Memory Circadian Rhythm Regulation Of Cell Size Visual Learning Response To Xenobiotic Stimulus Negative Regulation Of Gene Expression Negative Regulation Of Transcription By Competitive Promoter Binding Response To Purine-containing Compound Response To Activity Pituitary Gland Development Cell Differentiation Osteoclast Differentiation Mammary Gland Development Positive Regulation Of Transforming Growth Factor Beta3 Production Secretory Granule Organization Response To Glucagon Chemotaxis To Arachidonate Response To Nicotine Cellular Response To Hepatocyte Growth Factor Stimulus Response To Erythropoietin Cellular Response To Platelet-derived Growth Factor Stimulus Positive Regulation Of Multicellular Organism Growth Response To Cocaine MRNA Transcription By RNA Polymerase II Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Response To Morphine Response To Ethanol Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of Transcription By RNA Polymerase II Hormone Secretion Positive Regulation Of Hormone Secretion Positive Regulation Of Lipid Biosynthetic Process Regulation Of Fibroblast Proliferation Rhythmic Process Protein Stabilization Positive Regulation Of Cardiac Muscle Tissue Development Regulation Of Glial Cell Proliferation Lung Epithelium Development Lung Saccule Development Type I Pneumocyte Differentiation Cellular Response To Zinc Ion Cellular Response To Retinoic Acid Cellular Response To Growth Factor Stimulus Cellular Response To Fatty Acid Cellular Response To Transforming Growth Factor Beta Stimulus CAMP/PKA Signal Transduction Positive Regulation Of Long-term Synaptic Potentiation Response To L-glutamate Response To Dehydroepiandrosterone Positive Regulation Of Membrane Depolarization Cellular Response To Forskolin Cellular Response To Nerve Growth Factor Stimulus Cellular Response To Insulin-like Growth Factor Stimulus Cellular Response To Leukemia Inhibitory Factor Response To Hypobaric Hypoxia Regulation Of Testosterone Biosynthetic Process	Protein Phosphorylation Signal Transduction Chemical Synaptic Transmission Positive Regulation Of Cell Growth Negative Regulation Of TOR Signaling Intracellular Signal Transduction TORC1 Signaling Negative Regulation Of Apoptotic Process Regulation Of Translation In Response To Stress Positive Regulation Of Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Hepatocyte Proliferation Positive Regulation Of Hepatic Stellate Cell Activation
Pathways			ERK/MAPK targets CREB phosphorylation Senescence-Associated Secretory Phenotype (SASP) Senescence-Associated Secretory Phenotype (SASP) Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation Gastrin-CREB signalling pathway via PKC and MAPK Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs		Adenosine phosphate Naloxone	Purvalanol A Fostamatinib
Diseases
GWAS		Body mass index ( 25673413 28892062) Diastolic blood pressure ( 27841878) Food antigen IgG levels ( 24962563) Mean corpuscular hemoglobin ( 32888494) Refractive error ( 32231278) Systolic blood pressure ( 27841878)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Fasting plasma glucose ( 31932636) Glucose homeostasis traits ( 25524916) Lymphocyte count ( 32888494) Mean corpuscular volume ( 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Rosacea symptom severity ( 29771307) Triglyceride levels ( 30108155) White blood cell count ( 32888494)
Interacting Genes		86 interacting genes: ABL1 AGR2 AKT1 ATF1 ATF6 ATF7IP ATM ATR BRD10 CAMK2A CCDC6 CDK1 CEBPB CHD3 CHD8 CREBBP CREM CRTC1 CRTC2 CSNK1D CSNK2A1 CSNK2B DNMT3L DYRK1A EDF1 ERG28 ETS1 FHL5 GLI2 GSK3A GSK3B GTF2A1 GTF2F2 HIPK3 HIVEP1 HNF1B HPS6 KAT5 KCNIP3 MAPK14 MAPKAPK2 MTF2 NR3C1 PDX1 PIAS1 PIAS2 POGZ POU2F1 PPP1CA PRKACA PRKG1 PTEN RAB1A RBBP4 RECQL5 RFX3 RGS13 RNF111 RNF4 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA4 RPS6KA5 SGK1 SMARCA4 SMARCA5 SMCO1 SOX9 SRA1 SREBF2 SRF SUZ12 THRA TOX4 TRIM22 TSSK4 UBE2I VIM YY1 ZHX1 ZMYM2 ZNF35 ZNF436 ZNF451 ZNF92	88 interacting genes: ARHGEF11 ARHGEF12 ATM ATXN3 BAD CARHSP1 CCT4 CDKN1B CEBPB CFL1 CREB1 CREBBP DDAH2 DEPTOR DLC1 DLG4 EEF1D EEF2K ERBIN ESR1 ETV1 FGFR1 FOS GBP2 GMFB GOPC GORASP1 GORASP2 GRB2 GRID2IP GSK3B HTRA1 L1CAM LIMK2 LNX1 MAGI1 MAGI2 MAGI3 MAPK1 MAPK3 MAPT MAST1 MAST2 METTL1 MITF MPP1 MTOR MXD1 NFKBIA NHERF2 NR4A1 NR4A2 NR4A3 PARD3B PDCD4 PDPK1 PDZD7 PDZK1 PDZRN3 PDZRN4 PHAX POLDIP3 PPM1G PPP1R3A PPP1R9A PTPN3 RPTOR SHANK3 SHROOM2 SNTA1 SNTB1 SNTG2 SNX27 SRF SRSF5 STAT3 SYK SYNJ2BP TAMALIN TOB2 TP53 TSC2 TTK UBE2T VCP WHRN YBX1 YWHAB
Entrez ID		1385	6195
HPRD ID		00442	03402
Ensembl ID		ENSG00000118260	ENSG00000117676
Uniprot IDs		B7Z5C6 P16220 Q53X93 Q5U0J5	Q15418
PDB IDs		2LXT 5ZK1 5ZKO 7TBH	2WNT 2Z7Q 2Z7R 2Z7S 3RNY 3TEI 4H3P 4NIF 5CSF 5CSI 5CSJ 5CSN 5N7D 5N7F 5N7G 5V61 5V62 6TWY 7P74 7PC8 7QQL 8WF4 8XOV
Enriched GO Terms of Interacting Partners?		Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Nucleoplasm Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein Serine/threonine Kinase Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Serine Kinase Activity Protein Kinase Activity PML Body Kinase Activity Chromatin DNA Binding Negative Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation ATP Binding Transferase Activity Chromatin Remodeling Phosphorylation Cellular Response To Oxygen-containing Compound Cellular Response To Stress Positive Regulation Of CREB Transcription Factor Activity DNA-binding Transcription Factor Activity Chromatin Organization Sequence-specific DNA Binding Nucleic Acid Metabolic Process Intracellular Signal Transduction	Intracellular Signal Transduction Signal Transduction Intracellular Signaling Cassette Cytoplasm Phosphatase Binding Regulation Of Cell Development Positive Regulation Of Cellular Component Organization Cellular Response To Oxygen-containing Compound Regulation Of Cellular Component Organization Nuclear Glucocorticoid Receptor Binding Regulation Of Cell Population Proliferation Regulation Of Cell Differentiation Regulation Of Cellular Response To Heat Positive Regulation Of Protein-containing Complex Assembly Cellular Response To Nutrient Levels TOR Signaling Negative Regulation Of Signaling Negative Regulation Of Cell Communication Phosphorylation Regulation Of Signaling Regulation Of Cell Communication Negative Regulation Of TOR Signaling Regulation Of Multicellular Organismal Process Cellular Response To Hormone Stimulus Cellular Response To Peptide Hormone Stimulus Protein Phosphorylation Cellular Response To Stress TORC1 Signaling Regulation Of TORC1 Signaling Negative Regulation Of TORC1 Signaling Developmental Process Negative Regulation Of Signal Transduction Regulation Of Osteoclast Differentiation Response To Peptide Hormone Regulation Of Multicellular Organismal Development Negative Regulation Of Autophagy Response To Decreased Oxygen Levels Regulation Of TOR Signaling Negative Regulation Of Catabolic Process Intracellular Protein Localization Negative Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Organelle Organization Response To Oxygen Levels Regulation Of Developmental Process PDZ Domain Binding Response To Nutrient Levels Cellular Response To Cytokine Stimulus Regulation Of Apoptotic Process Regulation Of Intracellular Signal Transduction
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?