ELP3 and SMURF1

Number of citations of the paper that reports this interaction (PMID 15761153)
154

Data Source:
HPRD (in vivo)

		ELP3	SMURF1
Gene Name		elongator acetyltransferase complex subunit 3	SMAD specific E3 ubiquitin protein ligase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Histone Acetyltransferase Complex Nucleolus Cytoplasm Transcription Elongation Factor Complex Elongator Holoenzyme Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Axon Neuronal Cell Body Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Core Binding Protein Binding Phosphorylase Kinase Regulator Activity H3 Histone Acetyltransferase Activity H4 Histone Acetyltransferase Activity Metal Ion Binding Iron-sulfur Cluster Binding	Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity Activin Binding Ubiquitin Protein Ligase Activity I-SMAD Binding R-SMAD Binding
	Biological Process	Neuron Migration TRNA Wobble Uridine Modification Chromatin Organization Regulation Of Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Central Nervous System Development Positive Regulation Of Cell Migration Histone H3 Acetylation Histone H4 Acetylation Regulation Of Protein Kinase Activity	Protein Polyubiquitination Protein Export From Nucleus Transforming Growth Factor Beta Receptor Signaling Pathway Ectoderm Development Protein Ubiquitination Cell Differentiation Negative Regulation Of Ossification BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Receptor Catabolic Process Protein Localization To Cell Surface Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones	Loss of Function of TGFBR2 in Cancer Antigen processing: Ubiquitination & Proteasome degradation Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer TGF-beta receptor signaling activates SMADs Signaling by Wnt TGFBR1 LBD Mutants in Cancer Signaling by BMP Hedgehog 'on' state Class I MHC mediated antigen processing & presentation TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer beta-catenin independent WNT signaling Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Asymmetric localization of PCP proteins Signaling by Hedgehog PCP/CE pathway SMAD4 MH2 Domain Mutants in Cancer Adaptive Immune System
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233) Ulcerative colitis ( 20228798)
Protein-Protein Interactions		6 interactors: CTDP1 HIST1H4A HIST2H3C IKBKAP SMAD1 SMURF1	98 interactors: ANAPC5 AP2B1 APBB2 APP ARHGAP15 ARHGAP31 ARHGEF9 ARL14 ARL4D ASH2L AVEN AXIN1 CCM2 CDC40 CDK14 CDKL1 CSNK2A2 CUL5 CXXC1 DNAJC7 DUSP13 DVL2 ECSIT ELP3 ESR1 ETV6 FBXL15 FBXO30 FCHO1 GNG11 GRIPAP1 HDGFRP3 ING2 INPP5B IRAK2 JUNB LATS1 LHX9 LIMS1 LONRF3 MAP3K2 MAP3K3 NAA16 NDFIP2 NEDD8 OXSR1 PAK1 PAK1IP1 PDLIM7 PLEKHO1 POLR2A PSME3 PWP1 RASD2 RHOA RHPN2 RIPK2 RIT1 RNF11 RNF141 RPS27A RRP9 RTKN RUNX3 SASH3 SENP8 SF3A1 SMAD1 SMAD2 SMAD3 SMAD5 SMAD6 SMAD7 SPG20 SQSTM1 SRSF4 SRSF5 STK35 STRAP STUB1 TLN1 TNK2 TNNT1 TRAF4 TTC17 UBA52 UBB UBC UBE2D3 UBE2L3 UBTF UBXN1 USP45 USP9X WDR61 WEE1 WFS1 XPO1
Entrez ID		55140	57154
HPRD ID		10936	06902
Ensembl ID		ENSG00000134014	ENSG00000198742
Uniprot IDs		Q9H9T3	Q9HCE7
PDB IDs			2LAZ 2LB0 2LB1 2LTX 3PYC
Enriched GO Terms of Interacting Partners?		Gene Silencing DNA Methylation On Cytosine Chromatin Silencing At RDNA Regulation Of Gene Expression, Epigenetic Chromatin Silencing Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process DNA Methylation Transcription Elongation From RNA Polymerase II Promoter Negative Regulation Of Gene Expression, Epigenetic BMP Signaling Pathway DNA-templated Transcription, Elongation DNA Modification Cellular Protein Modification Process Gene Expression Transforming Growth Factor Beta Receptor Signaling Pathway Histone H4-K20 Demethylation Cellular Response To Transforming Growth Factor Beta Stimulus Transcription From RNA Polymerase II Promoter Response To Transforming Growth Factor Beta Regulation Of Ossification Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Regulation Of Nucleic Acid-templated Transcription Cellular Protein Metabolic Process Negative Regulation Of Megakaryocyte Differentiation Nucleobase-containing Compound Metabolic Process Primary MiRNA Processing Protein Complex Assembly Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Osteoblast Fate Commitment Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Hematopoietic Progenitor Cell Differentiation DNA Replication-dependent Nucleosome Assembly Exit From Mitosis SMAD Protein Complex Assembly Negative Regulation Of Gene Expression Nitrogen Compound Metabolic Process Protein Metabolic Process Mesodermal Cell Fate Commitment Methylation Regulation Of Megakaryocyte Differentiation Protein Localization To Cell Surface Receptor Catabolic Process Cardiac Muscle Cell Proliferation	Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Intracellular Signal Transduction Cellular Protein Modification Process Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Positive Regulation Of Cellular Protein Metabolic Process Signal Transduction Regulation Of Protein Ubiquitination Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Cellular Response To Organic Substance Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Protein Metabolic Process Cellular Protein Metabolic Process Regulation Of Signal Transduction Signaling Positive Regulation Of Metabolic Process Cell Communication Cellular Response To Stimulus Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Transferase Activity Negative Regulation Of Cellular Response To Growth Factor Stimulus Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Signaling Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Phosphorylation Transcription From RNA Polymerase II Promoter Protein Catabolic Process Regulation Of Cellular Process Transcription Initiation From RNA Polymerase II Promoter Proteolysis Involved In Cellular Protein Catabolic Process DNA-templated Transcription, Initiation Cellular Protein Catabolic Process Response To Organic Substance Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Metabolic Process Positive Regulation Of Ligase Activity Response To Stimulus Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Gene Expression
Tagcloud ?		aberrant alternative arrdc3 carcinomas cpg detect ductal explore follows frequency gata5 grades hypermethylation idcs inactivate inactivation islands lower lymph matched methylated methylation mnts node pax6 promoter represents suppressor unmethylated	5p acvr2a alters applying bmp bmp1a cleaves cluster copyright dies1 furin impairs interferes mapk3 micrornas mineralization mir osteoblast osteoblasts protected reprogramming reserved rights ski smad smad5 systematically tgfbr3 zfp423
Tagcloud (Difference) ?		aberrant alternative arrdc3 carcinomas cpg detect ductal explore follows frequency gata5 grades hypermethylation idcs inactivate inactivation islands lower lymph matched methylated methylation mnts node pax6 promoter represents suppressor unmethylated	5p acvr2a alters applying bmp bmp1a cleaves cluster copyright dies1 furin impairs interferes mapk3 micrornas mineralization mir osteoblast osteoblasts protected reprogramming reserved rights ski smad smad5 systematically tgfbr3 zfp423
Tagcloud (Intersection) ?