ELP3

Description		elongator acetyltransferase complex subunit 3
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GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Elongator Holoenzyme Complex
	Molecular Function	TRNA Binding RNA Binding Catalytic Activity Protein Binding Phosphorylase Kinase Regulator Activity Acetyltransferase Activity Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding TRNA Uridine(34) Acetyltransferase Activity
	Biological Process	Neuron Migration TRNA Wobble Uridine Modification TRNA Wobble Base 5-methoxycarbonylmethyl-2-thiouridinylation Regulation Of Transcription By RNA Polymerase II Regulation Of Translation Nervous System Development Central Nervous System Development TRNA Processing Positive Regulation Of Cell Migration
Pathways		HATs acetylate histones
Drugs
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 28892062) Body size at age 10 ( 32376654) Childhood body mass index ( 26604143 33045005) Malaria ( 31844061) Systemic lupus erythematosus ( 28714469)
Novel Interacting Genes		1 novel interacting genes: ELP4
Interacting Genes		8 interacting genes: CTDP1 ELP1 ELP6 H3C14 H4C1 MYC SMAD1 SMURF1
Entrez ID		55140
HPRD ID		10936
Ensembl ID		ENSG00000134014
Uniprot IDs		B4DKA4 B4DXV1 Q9H9T3
PDB IDs		8PTX 8PTY 8PTZ 8PU0
Enriched GO Terms of Interacting Partners?		Elongator Holoenzyme Complex TRNA Wobble Uridine Modification TRNA Modification RNA Metabolic Process I-SMAD Binding TRNA Processing RNA Modification TRNA Metabolic Process Nucleic Acid Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Multicellular Organismal Development Positive Regulation Of MiRNA Metabolic Process Intracellular Iron Ion Homeostasis Protein-containing Complex Negative Regulation Of Cell Differentiation Macromolecule Metabolic Process Positive Regulation Of MiRNA Transcription Macromolecule Biosynthetic Process Regulation Of Cell Differentiation Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding Inflammasome-mediated Signaling Pathway Engulfment Of Target By Autophagosome Nucleobase-containing Compound Metabolic Process Negative Regulation Of Muscle Cell Differentiation RNA Processing Regulation Of MiRNA Transcription Regulation Of Macromolecule Metabolic Process Nucleoplasm BMP Signaling Pathway Structural Constituent Of Chromatin Negative Regulation Of Developmental Process Homomeric SMAD Protein Complex Regulation Of MiRNA Metabolic Process Negative Regulation Of Myeloid Cell Differentiation Myc-Max Complex Regulation Of Acinar Cell Proliferation Regulation Of Translation TFIIF-class Transcription Factor Complex Binding Regulation Of Metabolic Process Mesodermal Cell Fate Commitment Osteoblast Fate Commitment NK T Cell Proliferation Nucleosome Assembly TRNA Wobble Base 5-methoxycarbonylmethyl-2-thiouridinylation Phosphorylase Kinase Regulator Activity Homeostasis Of Number Of Retina Cells Nucleosome
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