ELP3 and ELP6

Number of citations of the paper that reports this interaction (PubMedID 36617428)
102

Data Source:
BioGRID (affinity chromatography technology, pull down)

		ELP3	ELP6
Description		elongator acetyltransferase complex subunit 3	elongator acetyltransferase complex subunit 6
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Elongator Holoenzyme Complex	Nucleus Cytoplasm Cytosol Elongator Holoenzyme Complex
	Molecular Function	TRNA Binding RNA Binding Catalytic Activity Protein Binding Phosphorylase Kinase Regulator Activity Acetyltransferase Activity Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding TRNA Uridine(34) Acetyltransferase Activity	Protein Binding
	Biological Process	Neuron Migration TRNA Wobble Uridine Modification TRNA Wobble Base 5-methoxycarbonylmethyl-2-thiouridinylation Regulation Of Transcription By RNA Polymerase II Regulation Of Translation Nervous System Development Central Nervous System Development TRNA Processing Positive Regulation Of Cell Migration	TRNA Wobble Uridine Modification Translation Regulation Of Translation Protein Folding Autophagy Apoptotic Process Response To Unfolded Protein Locomotory Behavior TRNA Processing Ubiquitin Recycling Positive Regulation Of Cell Migration Cellular Response To Stress Photoreceptor Cell Differentiation Homeostasis Of Number Of Retina Cells Neuromuscular Process Controlling Balance Neuromuscular Process Neuron Apoptotic Process Retina Development In Camera-type Eye Motor Behavior Autophagosome Maturation Inflammasome-mediated Signaling Pathway
Pathways		HATs acetylate histones	HATs acetylate histones
Drugs
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 28892062) Body size at age 10 ( 32376654) Childhood body mass index ( 26604143 33045005) Malaria ( 31844061) Systemic lupus erythematosus ( 28714469)	Refractive error ( 32231278)
Interacting Genes		8 interacting genes: CTDP1 ELP1 ELP6 H3C14 H4C1 MYC SMAD1 SMURF1	7 interacting genes: CLK1 ELP1 ELP2 ELP3 ELP4 MLH1 SRPK2
Entrez ID		55140	54859
HPRD ID		10936	07884
Ensembl ID		ENSG00000134014	ENSG00000163832
Uniprot IDs		B4DKA4 B4DXV1 Q9H9T3	C9IYN7 Q0PNE2
PDB IDs		8PTX 8PTY 8PTZ 8PU0
Enriched GO Terms of Interacting Partners?		Elongator Holoenzyme Complex TRNA Wobble Uridine Modification TRNA Modification RNA Metabolic Process I-SMAD Binding TRNA Processing RNA Modification TRNA Metabolic Process Nucleic Acid Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Multicellular Organismal Development Positive Regulation Of MiRNA Metabolic Process Intracellular Iron Ion Homeostasis Protein-containing Complex Negative Regulation Of Cell Differentiation Macromolecule Metabolic Process Positive Regulation Of MiRNA Transcription Macromolecule Biosynthetic Process Regulation Of Cell Differentiation Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding Inflammasome-mediated Signaling Pathway Engulfment Of Target By Autophagosome Nucleobase-containing Compound Metabolic Process Negative Regulation Of Muscle Cell Differentiation RNA Processing Regulation Of MiRNA Transcription Regulation Of Macromolecule Metabolic Process Nucleoplasm BMP Signaling Pathway Structural Constituent Of Chromatin Negative Regulation Of Developmental Process Homomeric SMAD Protein Complex Regulation Of MiRNA Metabolic Process Negative Regulation Of Myeloid Cell Differentiation Myc-Max Complex Regulation Of Acinar Cell Proliferation Regulation Of Translation TFIIF-class Transcription Factor Complex Binding Regulation Of Metabolic Process Mesodermal Cell Fate Commitment Osteoblast Fate Commitment NK T Cell Proliferation Nucleosome Assembly TRNA Wobble Base 5-methoxycarbonylmethyl-2-thiouridinylation Phosphorylase Kinase Regulator Activity Homeostasis Of Number Of Retina Cells Nucleosome	Elongator Holoenzyme Complex TRNA Wobble Uridine Modification TRNA Modification TRNA Processing RNA Modification TRNA Wobble Base 5-methoxycarbonylmethyl-2-thiouridinylation Phosphorylase Kinase Regulator Activity TRNA Metabolic Process RNA Metabolic Process RNA Processing Regulation Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Transcription Elongation Factor Complex Regulation Of Primary Metabolic Process Nucleic Acid Metabolic Process Post-transcriptional Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleus Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment TRNA Uridine(34) Acetyltransferase Activity TRNA Binding Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment Chiasma Male Meiosis Chromosome Segregation MutLalpha Complex Guanine/thymine Mispair Binding Negative Regulation Of Mitotic Recombination Nuclear Speck Organization Regulation Of Nucleobase-containing Compound Metabolic Process Homologous Chromosome Segregation Female Meiosis Chromosome Segregation Mismatch Repair Complex Positive Regulation Of Isotype Switching To IgA Isotypes Intrinsic Apoptotic Signaling Pathway Regulation Of RNA Splicing MutSalpha Complex Binding Regulation Of Mitotic Recombination Regulation Of Protein Metabolic Process Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Telomere Localization R-loop Processing Mismatched DNA Binding Positive Regulation Of Isotype Switching To IgG Isotypes PERK-mediated Unfolded Protein Response
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