ELP3 and IKBKAP

Number of citations of the paper that reports this interaction (PMID 22939629)
44

Data Source:
BioGRID (pull down, biochemical, affinity chromatography technology)

		ELP3	IKBKAP
Gene Name		elongator acetyltransferase complex subunit 3	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Histone Acetyltransferase Complex Nucleolus Cytoplasm Transcription Elongation Factor Complex Elongator Holoenzyme Complex	Histone Acetyltransferase Complex Nucleolus Cytoplasm Transcription Elongation Factor Complex Elongator Holoenzyme Complex
	Molecular Function	RNA Polymerase II Core Binding Protein Binding Phosphorylase Kinase Regulator Activity H3 Histone Acetyltransferase Activity H4 Histone Acetyltransferase Activity Metal Ion Binding Iron-sulfur Cluster Binding	RNA Polymerase II Core Binding Signal Transducer Activity Protein Binding Phosphorylase Kinase Regulator Activity
	Biological Process	Neuron Migration TRNA Wobble Uridine Modification Chromatin Organization Regulation Of Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Central Nervous System Development Positive Regulation Of Cell Migration Histone H3 Acetylation Histone H4 Acetylation Regulation Of Protein Kinase Activity	Chromatin Organization Regulation Of Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Protein Complex Assembly Protein Phosphorylation Immune Response Signal Transduction Positive Regulation Of Cell Migration Regulation Of Protein Kinase Activity
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones	Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: CTDP1 HIST1H4A HIST2H3C IKBKAP SMAD1 SMURF1	26 interactors: BAG6 BARD1 CCT5 CDKN2B CHUK CSTF2 ELP2 ELP3 HTT IKBKB IRF4 MAN2A2 MAP3K14 MAP3K7 MAPK8 MRPL42 NDUFB9 NFKBIA NIPSNAP3A PBX2 PLP2 SDHAF2 SNAPIN TAC3 TTR TXNDC9
Entrez ID		55140	8518
HPRD ID		10936	04763
Ensembl ID		ENSG00000134014	ENSG00000070061
Uniprot IDs		Q9H9T3	O95163 Q8N516
PDB IDs
Enriched GO Terms of Interacting Partners?		Gene Silencing DNA Methylation On Cytosine Chromatin Silencing At RDNA Regulation Of Gene Expression, Epigenetic Chromatin Silencing Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process DNA Methylation Transcription Elongation From RNA Polymerase II Promoter Negative Regulation Of Gene Expression, Epigenetic BMP Signaling Pathway DNA-templated Transcription, Elongation DNA Modification Cellular Protein Modification Process Gene Expression Transforming Growth Factor Beta Receptor Signaling Pathway Histone H4-K20 Demethylation Cellular Response To Transforming Growth Factor Beta Stimulus Transcription From RNA Polymerase II Promoter Response To Transforming Growth Factor Beta Regulation Of Ossification Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Regulation Of Nucleic Acid-templated Transcription Cellular Protein Metabolic Process Negative Regulation Of Megakaryocyte Differentiation Nucleobase-containing Compound Metabolic Process Primary MiRNA Processing Protein Complex Assembly Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Osteoblast Fate Commitment Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Hematopoietic Progenitor Cell Differentiation DNA Replication-dependent Nucleosome Assembly Exit From Mitosis SMAD Protein Complex Assembly Negative Regulation Of Gene Expression Nitrogen Compound Metabolic Process Protein Metabolic Process Mesodermal Cell Fate Commitment Methylation Regulation Of Megakaryocyte Differentiation Protein Localization To Cell Surface Receptor Catabolic Process Cardiac Muscle Cell Proliferation	Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Toll-like Receptor 4 Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response I-kappaB Kinase/NF-kappaB Signaling I-kappaB Phosphorylation Response To External Stimulus Positive Regulation Of Innate Immune Response Fc-epsilon Receptor Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Innate Immune Response T Cell Receptor Signaling Pathway Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Fc Receptor Signaling Pathway Internal Protein Amino Acid Acetylation Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Acetylation Antigen Receptor-mediated Signaling Pathway Histone H3 Acetylation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Growth Factor Stimulus Response To Growth Factor Negative Regulation Of Apoptotic Process Positive Regulation Of Cytokine Production Negative Regulation Of Programmed Cell Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune Response-regulating Cell Surface Receptor Signaling Pathway Peptidyl-amino Acid Modification Regulation Of Signal Transduction Negative Regulation Of Cell Death Intracellular Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Organic Substance Neurotrophin TRK Receptor Signaling Pathway Response To Other Organism Positive Regulation Of Type I Interferon Production
Tagcloud ?		aberrant alternative arrdc3 carcinomas cpg detect ductal explore follows frequency gata5 grades hypermethylation idcs inactivate inactivation islands lower lymph matched methylated methylation mnts node pax6 promoter represents suppressor unmethylated	advance autonomously autosomal awaited believed compensate deficiencies devastating dysautonomia faithfully fd hallmark ikap implicating myelin myelination neurodevelopmental oli oligodendrocyte postmortem proof reason recapitulate recessive scarcity severely skipping splice underscoring
Tagcloud (Difference) ?		aberrant alternative arrdc3 carcinomas cpg detect ductal explore follows frequency gata5 grades hypermethylation idcs inactivate inactivation islands lower lymph matched methylated methylation mnts node pax6 promoter represents suppressor unmethylated	advance autonomously autosomal awaited believed compensate deficiencies devastating dysautonomia faithfully fd hallmark ikap implicating myelin myelination neurodevelopmental oli oligodendrocyte postmortem proof reason recapitulate recessive scarcity severely skipping splice underscoring
Tagcloud (Intersection) ?