ATG4A and MAP1LC3B

Number of citations of the paper that reports this interaction (PMID 20010802)
140

Data Source:
BioGRID (two hybrid)

		ATG4A	MAP1LC3B
Gene Name		autophagy related 4A, cysteine peptidase	microtubule-associated protein 1 light chain 3 beta
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol	Pre-autophagosomal Structure Autophagic Vacuole Membrane Intracellular Autophagic Vacuole Cytosol Microtubule Axoneme Endomembrane System Extrinsic Component Of Membrane Organelle Membrane Cytoplasmic Vesicle
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Peptidase Activity	Protein Binding Microtubule Binding GABA Receptor Binding
	Biological Process	Autophagic Vacuole Assembly Mitochondrion Degradation C-terminal Protein Lipidation Proteolysis Protein Targeting To Membrane Cellular Response To Nitrogen Starvation Protein Processing Nucleophagy Protein Delipidation	Autophagic Vacuole Assembly Mitochondrion Degradation Cellular Response To Nitrogen Starvation Nucleophagy Membrane Fusion
Pathways
Drugs
Diseases
GWAS			Major depressive disorder ( 22472876)
Protein-Protein Interactions		5 interactors: ATG101 CDKL3 GABARAPL1 GABARAPL2 MAP1LC3B	50 interactors: AAMP ADD1 ADNP ARFGAP1 ATG3 ATG4A ATG4B ATG7 BNIP3 BRD3 CASP8 CCSER2 CLTA DBI DBN1 DNMT3B EED EPS8 FAM134A FAM65A FUNDC1 FYCO1 GABARAPL2 GORASP2 KBTBD7 KLHL5 KXD1 LUC7L2 MKRN1 MRFAP1 MYBL2 NHP2L1 RAD1 RAP1GAP RPLP1 SAFB SHFM1 SMARCB1 SPAG9 SQSTM1 TAF7 TAX1BP1 TBC1D17 TBC1D25 TBC1D9 TBC1D9B THAP7 TMOD3 TNIP1 UPF2
Entrez ID		115201	81631
HPRD ID		06455	14358
Ensembl ID		ENSG00000101844	ENSG00000140941
Uniprot IDs		F5H3G3 Q8WYN0	H6UMI0 Q658J6 Q9GZQ8
PDB IDs		2FUY 2P82	1V49 2LUE 2ZJD 3VTU 3VTV 3VTW
Enriched GO Terms of Interacting Partners?		Autophagic Vacuole Assembly Macroautophagy Vacuole Organization Cellular Response To Starvation Nucleophagy Autophagy Mitochondrion Degradation Cellular Response To Nutrient Levels Response To Starvation Cellular Response To Extracellular Stimulus Organelle Disassembly Response To Nutrient Levels Response To Extracellular Stimulus Organelle Assembly Membrane Fusion Cellular Response To Nitrogen Starvation Mitochondrion Organization Cellular Response To Stress Catabolic Process Response To External Stimulus Cellular Component Assembly Membrane Organization Dendrite Extension Organelle Organization Response To Stress Negative Regulation Of Axon Extension Positive Regulation Of ATPase Activity Positive Regulation Of Dendrite Morphogenesis Regulation Of ATPase Activity Intra-Golgi Vesicle-mediated Transport Positive Regulation Of Dendrite Development Negative Regulation Of Axonogenesis Neuron Projection Extension Cell Communication Negative Regulation Of Proteasomal Protein Catabolic Process Cellular Metabolic Process Regulation Of Axon Extension Regulation Of Dendrite Morphogenesis	Autophagy Mitochondrion Degradation Organelle Disassembly Nucleophagy Cellular Response To Nitrogen Starvation Macroautophagy Regulation Of Organelle Organization Cellular Response To Starvation Positive Regulation Of Metabolic Process Organelle Organization Positive Regulation Of Autophagy Response To Starvation Cellular Response To Nutrient Levels Autophagic Vacuole Assembly Cellular Response To Extracellular Stimulus Cellular Response To Stress Intracellular Transport Catabolic Process Mitochondrion Organization Regulation Of Cellular Component Organization C-terminal Protein Lipidation Protein Delipidation Membrane Organization Response To Stress Vacuole Organization Regulation Of Autophagy Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Complex Disassembly Establishment Of Localization In Cell Regulation Of Histone Modification Actin Filament Capping Positive Regulation Of Rab GTPase Activity Regulation Of Rab GTPase Activity Regulation Of Rab Protein Signal Transduction Mitochondrial Fragmentation Involved In Apoptotic Process Positive Regulation Of Hydrolase Activity Cellular Localization Negative Regulation Of Actin Filament Depolymerization Response To Nutrient Levels Cellular Component Assembly Protein Localization Regulation Of Ras Protein Signal Transduction Response To Extracellular Stimulus Response To Cobalt Ion Protein Targeting To Membrane Regulation Of Actin Filament Depolymerization Organelle Assembly Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Macroautophagy Negative Regulation Of Histone Acetylation
Tagcloud ?		activates atg9a autophagy bix bix01294 deficiency detailed discovered dor elusive emerged enhances h3k9 induces inducing lc3 lc3b methyltransferase profiled promotes promoting puma rapamycin repressed screen selectively smyd2 transcriptionally typical	akt1 antipsychotic atg atg12 atg4b atg5 atg7 autophagic autophagosome autophagosomes autophagy bak1 bcl2l11 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth olanzapine overtly pmaip1 sqstm1 sy5y trp53 unmask
Tagcloud (Difference) ?		activates atg9a bix bix01294 deficiency detailed discovered dor elusive emerged enhances h3k9 induces inducing lc3 methyltransferase profiled promotes promoting puma rapamycin repressed screen selectively smyd2 transcriptionally typical	akt1 antipsychotic atg atg12 atg4b atg5 atg7 autophagic autophagosome autophagosomes bak1 bcl2l11 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth olanzapine overtly pmaip1 sqstm1 sy5y trp53 unmask
Tagcloud (Intersection) ?		autophagy lc3b