ATG4A and CDKL3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		ATG4A	CDKL3
Description		autophagy related 4A cysteine peptidase	cyclin dependent kinase like 3
Image
GO Annotations	Cellular Component	Cytoplasm	Nucleus Cytoplasm
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Protein-phosphatidylethanolamide Deconjugating Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Autophagosome Assembly Mitophagy Proteolysis Lipid Metabolic Process Autophagy Protein Transport Protein Processing Piecemeal Microautophagy Of The Nucleus Aggrephagy Protein Delipidation	Negative Regulation Of Axon Extension Protein Modification Process Positive Regulation Of Dendrite Morphogenesis Regulation Of Cell Cycle Dendrite Extension
Pathways		Macroautophagy
Drugs
Diseases
GWAS			Eosinophil count ( 27863252) Moderate-to-late spontaneous preterm birth ( 31194736)
Interacting Genes		5 interacting genes: ATG101 CDKL3 GABARAPL1 GABARAPL2 MAP1LC3B	31 interacting genes: APP ATG4A CYSRT1 DISC1 DNAAF6 FXR1 FXR2 GGA1 GOLGA2 IKZF1 KANK2 KASH5 KRTAP10-9 LRP2BP LRRK2 LZTS2 MCC MDFI MTUS2 PICK1 PIH1D2 RABEP1 SNRNP70 SRPK1 TRIM27 TRIM37 TTF2 ZBTB14 ZBTB43 ZBTB8A ZRANB1
Entrez ID		115201	51265
HPRD ID		06455	09766
Ensembl ID		ENSG00000101844	ENSG00000006837
Uniprot IDs		B4DEA4 Q8WYN0	B4DX41 Q8IVW4
PDB IDs		2P82	3ZDU
Enriched GO Terms of Interacting Partners?		Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Autophagosome Assembly Autophagosome Organization Vacuole Organization Autophagosome Maturation Autophagosome Membrane Mitophagy Autophagy Autophagy Of Mitochondrion Autophagosome Phospholipid Binding Protein-containing Complex Disassembly Macroautophagy GABA Receptor Binding Cellular Response To Starvation Organelle Assembly Response To Starvation Cellular Response To Nutrient Levels Ubiquitin Protein Ligase Binding Beta-tubulin Binding Response To Nutrient Levels Catabolic Process Cytoplasmic Vesicle Cellular Component Assembly Organelle Organization Microtubule Binding Atg1/ULK1 Kinase Complex Ceramide Binding Tat Protein Binding Dendrite Extension Glycophagy Microtubule Protein Localization To Endoplasmic Reticulum Protein-containing Complex Organization Positive Regulation Of ATP-dependent Activity Glycogen Catabolic Process Cellular Response To Stress Polysaccharide Catabolic Process Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Axon Extension Phagophore Assembly Site Intra-Golgi Vesicle-mediated Transport Regulation Of ATP-dependent Activity Positive Regulation Of Dendrite Morphogenesis Cytoplasm Organelle Membrane	Regulation Of Wnt Signaling Pathway Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Autophagy Positive Regulation Of Catabolic Process Protein Localization To Ciliary Membrane Cellular Response To Manganese Ion Positive Regulation Of Long-term Neuronal Synaptic Plasticity Wnt Signaling Pathway Regulation Of Neuronal Synaptic Plasticity Cellular Component Assembly Negative Regulation Of Long-term Synaptic Potentiation Identical Protein Binding Negative Regulation Of Wnt Signaling Pathway Modulation Of Chemical Synaptic Transmission Protein Homodimerization Activity Cellular Localization Response To Manganese Ion Neuron Projection Regulation Of Receptor Internalization Cytoplasm Regulation Of Synaptic Transmission, Glutamatergic Golgi-associated Vesicle Cellular Response To Catecholamine Stimulus Translation Regulator Activity Regulation Of Synaptic Plasticity Positive Regulation Of Protein Metabolic Process Response To Catecholamine Negative Regulation Of Catabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Postsynapse Presynapse Regulation Of Primary Metabolic Process Dentate Gyrus Development Regulation Of Canonical Wnt Signaling Pathway Intracellular Transport Positive Regulation Of Receptor Internalization Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Negative Regulation Of Transcription By RNA Polymerase II Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Macromolecule Metabolic Process Organelle Assembly Aggresome
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