ZHX1 and ZYX

Number of citations of the paper that reports this interaction (PubMedID 12659632)
33

Data Source:
BioGRID (two hybrid)

		ZHX1	ZYX
Description		zinc fingers and homeoboxes 1	zyxin
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Stress Fiber Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion Actin Cytoskeleton Phagocytic Vesicle Anchoring Junction
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding Protein Heterodimerization Activity	RNA Binding Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cell Differentiation Negative Regulation Of DNA-templated Transcription	Cell Adhesion Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Cell-cell Signaling Stress Fiber Assembly Cellular Response To Type II Interferon
Pathways
Drugs			Artenimol
Diseases
GWAS			Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) White blood cell count (basophil) ( 27863252)
Interacting Genes		54 interacting genes: AKR1C3 AKT1 ATXN1 BARD1 BCL2L1 BHLHE40 BID CHD3 CREB1 CREBBP CSNK2A1 DDX39B DLST DYNLL1 EFNA2 ELL GADD45A GNG11 GSK3B HSPE1 IDH1 LAMA4 LYAR MPHOSPH6 NACA NFYA PAFAH1B3 PEX14 PIAS4 PIGC PNP PRPF40A PSMD11 SAT1 SERPINB9 SUMO1 SUMO2 TAL1 TALDO1 TARDBP TERF1 TNFRSF10C TOLLIP TP53 UBC UTP3 VIM WDR33 ZBED1 ZHX2 ZHX3 ZMYND11 ZNF33B ZYX	36 interacting genes: ACTN1 ATXN1 BSPRY CASS4 CEBPA ENAH EVL HIPK3 IMP3 LAP3 LASP1 LATS1 LIN7A NEBL NEDD9 NME5 OPRM1 PDLIM5 PHF21A QRICH1 RABEPK RGS2 RPH3AL RTN4IP1 SIAH1 SREBF2 TES TUFT1 VASP VAV1 VAV3 WNK1 YPEL3 ZHX1 ZNF384 ZNF512B
Entrez ID		11244	7791
HPRD ID		10379	03592
Ensembl ID		ENSG00000165156	ENSG00000159840
Uniprot IDs		Q9UKY1	Q15942 Q96AF9
PDB IDs		2ECB 2GHF 2LY9 3NAR
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleus Nucleoplasm Negative Regulation Of Metabolic Process Nucleic Acid Metabolic Process Negative Regulation Of RNA Metabolic Process PML Body Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Identical Protein Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Rhythmic Process Negative Regulation Of RNA Biosynthetic Process Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein-containing Complex Assembly RNA Metabolic Process Ubiquitin Protein Ligase Binding Negative Regulation Of Protein Localization Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Programmed Cell Death Positive Regulation Of Programmed Cell Death Response To Radiation Regulation Of Release Of Cytochrome C From Mitochondria RNA Binding Positive Regulation Of Metabolic Process Protein Tag Activity Cellular Response To Stress Protein Sumoylation Positive Regulation Of Macromolecule Metabolic Process Response To Stress Regulation Of Macromolecule Metabolic Process Regulation Of Mitochondrion Organization Regulation Of Apoptotic Signaling Pathway DNA Damage Response Regulation Of Mitochondrial Membrane Permeability RNA Polymerase II-specific DNA-binding Transcription Factor Binding SUMO Transferase Activity Protein Binding Regulation Of Cellular Response To Stress	Focal Adhesion Profilin Binding Anchoring Junction Actin Filament Organization Actin Binding Postsynapse Regulation Of Cellular Component Size Cytoplasm Stress Fiber Supramolecular Fiber Organization Lymphocyte Migration Into Lymphoid Organs Positive Regulation Of Protein Tyrosine Kinase Activity Actin Polymerization Or Depolymerization Platelet Activation Cytoskeletal Protein Binding Cytoskeleton Lamellipodium Regulation Of Cell Size
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