ZHX1 and PAFAH1B3

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ZHX1	PAFAH1B3
Gene Name		zinc fingers and homeoboxes 1	platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Cytoplasm Cytosol Membrane Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Metal Ion Binding Protein Heterodimerization Activity	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Protein Binding Protein Heterodimerization Activity Platelet-activating Factor Acetyltransferase Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Cell Differentiation Negative Regulation Of Transcription, DNA-templated	Lipid Metabolic Process Spermatogenesis Nervous System Development Brain Development Lipid Catabolic Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		50 interactors: AKR1C3 AKT1 ATXN1 BARD1 BCL2L1 BHLHE40 BID CHD3 CREB1 CSNK2A1 DDX39B DLST DYNLL1 EFNA2 ELL GADD45A GNG11 GSK3B HSPE1 IDH1 LAMA4 LYAR MPHOSPH6 NACA NFYA PAFAH1B3 PEX14 PIAS4 PIGC PNP PRPF40A PSMD11 SAT1 SERPINB9 SUMO2 TAL1 TALDO1 TARDBP TERF1 TNFRSF10C TOLLIP TP53 UTP3 VIM WDR33 ZHX2 ZHX3 ZMYND11 ZNF33B ZYX	33 interactors: BRD7 C14orf1 CCDC90B CHMP7 COPS6 CRMP1 DDX24 ECH1 EEF1A1 GAPDH GBP2 GDF9 HSPH1 IGSF21 LNX1 LRIF1 MED31 PAFAH1B1 PAFAH1B2 PLEKHM1 RBM48 SDCBP2 SETDB1 SUMO4 TERF1 TERF2IP TLE1 TP53 TUBB2A UNC119 XRCC6 ZBTB16 ZHX1
Entrez ID		11244	5050
HPRD ID		10379	04354
Ensembl ID		ENSG00000165156	ENSG00000079462
Uniprot IDs		Q9UKY1	Q15102
PDB IDs		2ECB 2GHF 2LY9 3NAR
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Cell Death Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cell Death Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Viral Process Regulation Of Mitochondrion Organization Negative Regulation Of Biosynthetic Process Apoptotic Process RNA Metabolic Process Programmed Cell Death Cell Death Death Cellular Metabolic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cell Cycle Gene Expression Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Transcription, DNA-templated Negative Regulation Of Gene Expression Cell Cycle Negative Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Rhythmic Process Negative Regulation Of Cell Cycle Developmental Process Positive Regulation Of Protein Metabolic Process Biosynthetic Process Positive Regulation Of Protein Catabolic Process Cell Cycle Process Regulation Of Cell Cycle Process Regulation Of Proteolysis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Cellular Process Negative Regulation Of Transcription, DNA-templated	Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Biosynthetic Process Transcription, DNA-templated Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance RNA Biosynthetic Process Regulation Of Chromosome Organization Telomere Maintenance Negative Regulation Of Gene Expression Cell Division Negative Regulation Of DNA Metabolic Process RNA Metabolic Process Cell Separation After Cytokinesis Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Telomere Maintenance Negative Regulation Of Transcription, DNA-templated RNA-dependent DNA Replication Negative Regulation Of Nucleic Acid-templated Transcription Cellular Nitrogen Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Cellular Metabolic Process Response To X-ray Cellular Macromolecule Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Mitotic Cell Cycle Phase Transition Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Fibroblast Proliferation Biosynthetic Process Macromolecule Biosynthetic Process Response To Salt Stress Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Stem Cell Division Chromosome Organization Mitotic Cell Cycle Process Negative Regulation Of Clathrin-mediated Endocytosis Peptidyl-cysteine S-trans-nitrosylation Negative Regulation Of DNA Recombination At Telomere Regulation Of Mitotic Cell Cycle Negative Regulation Of DNA Replication Gene Expression Mitotic Cell Cycle Neuron Apoptotic Process Cellular Response To Ionizing Radiation Negative Regulation Of Transcription From RNA Polymerase II Promoter 'de Novo' Posttranslational Protein Folding Metabolic Process
Tagcloud ?		199a 3p accumulating bound carcinogenesis direct dramatically epigenetic fingers gastric gc homeoboxes inversely involve micrornas mir mirnas n87 nci oncogenic regulator regulators restoring sgc suppressed untranslated upregulated utr zinc	abpp acetylhydrolase acyl aided campaign carbamate carbamoylation cherry endeavored fluopol hits house hts hydrolase hydrolases medchem ml256 mudpit oxidatively phospholipids picked pla2g7 scaffold sid tunable
Tagcloud (Difference) ?		199a 3p accumulating bound carcinogenesis direct dramatically epigenetic fingers gastric gc homeoboxes inversely involve micrornas mir mirnas n87 nci oncogenic regulator regulators restoring sgc suppressed untranslated upregulated utr zinc	abpp acetylhydrolase acyl aided campaign carbamate carbamoylation cherry endeavored fluopol hits house hts hydrolase hydrolases medchem ml256 mudpit oxidatively phospholipids picked pla2g7 scaffold sid tunable
Tagcloud (Intersection) ?