ZHX1 and EFNA2

Number of citations of the paper that reports this interaction (PubMedID 12659632)
33

Data Source:
BioGRID (two hybrid)

		ZHX1	EFNA2
Description		zinc fingers and homeoboxes 1	ephrin A2
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Plasma Membrane Membrane Neuromuscular Junction Perikaryon Side Of Membrane
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding Protein Heterodimerization Activity	Protein Binding Ephrin Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cell Differentiation Negative Regulation Of DNA-templated Transcription	Cell-cell Signaling Axon Guidance Olfactory Bulb Development Osteoclast Differentiation Bone Remodeling Ephrin Receptor Signaling Pathway
Pathways			EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells
Drugs
Diseases
GWAS			Response to selenium supplementation (change in plasma selenium concentration) ( 33382417)
Interacting Genes		54 interacting genes: AKR1C3 AKT1 ATXN1 BARD1 BCL2L1 BHLHE40 BID CHD3 CREB1 CREBBP CSNK2A1 DDX39B DLST DYNLL1 EFNA2 ELL GADD45A GNG11 GSK3B HSPE1 IDH1 LAMA4 LYAR MPHOSPH6 NACA NFYA PAFAH1B3 PEX14 PIAS4 PIGC PNP PRPF40A PSMD11 SAT1 SERPINB9 SUMO1 SUMO2 TAL1 TALDO1 TARDBP TERF1 TNFRSF10C TOLLIP TP53 UBC UTP3 VIM WDR33 ZBED1 ZHX2 ZHX3 ZMYND11 ZNF33B ZYX	5 interacting genes: ADAM10 EPHA2 EPHA3 EPHA5 ZHX1
Entrez ID		11244	1943
HPRD ID		10379	04132
Ensembl ID		ENSG00000165156	ENSG00000099617
Uniprot IDs		Q9UKY1	O43921
PDB IDs		2ECB 2GHF 2LY9 3NAR	2WO3
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleus Nucleoplasm Negative Regulation Of Metabolic Process Nucleic Acid Metabolic Process Negative Regulation Of RNA Metabolic Process PML Body Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Identical Protein Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Rhythmic Process Negative Regulation Of RNA Biosynthetic Process Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein-containing Complex Assembly RNA Metabolic Process Ubiquitin Protein Ligase Binding Negative Regulation Of Protein Localization Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Programmed Cell Death Positive Regulation Of Programmed Cell Death Response To Radiation Regulation Of Release Of Cytochrome C From Mitochondria RNA Binding Positive Regulation Of Metabolic Process Protein Tag Activity Cellular Response To Stress Protein Sumoylation Positive Regulation Of Macromolecule Metabolic Process Response To Stress Regulation Of Macromolecule Metabolic Process Regulation Of Mitochondrion Organization Regulation Of Apoptotic Signaling Pathway DNA Damage Response Regulation Of Mitochondrial Membrane Permeability RNA Polymerase II-specific DNA-binding Transcription Factor Binding SUMO Transferase Activity Protein Binding Regulation Of Cellular Response To Stress	Ephrin Receptor Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Signaling Pathway GPI-linked Ephrin Receptor Activity Regulation Of Cellular Localization Protein Tyrosine Kinase Activity Regulation Of GTPase Activity Regulation Of Protein Localization To Cell Periphery Transmembrane-ephrin Receptor Activity Regulation Of Protein Localization To Membrane Regulation Of Protein Localization Positive Regulation Of Protein Localization To Plasma Membrane Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Dendrite Positive Regulation Of Protein Localization To Cell Periphery Protein Kinase Activity Positive Regulation Of Protein Localization To Membrane Constitutive Protein Ectodomain Proteolysis Notochord Cell Development Regulation Of Catalytic Activity Kinase Activity Regulation Of Protein Localization To Plasma Membrane Epidermal Growth Factor Receptor Ligand Maturation Enzyme-linked Receptor Protein Signaling Pathway Axial Mesoderm Formation Fasciculation Of Motor Neuron Axon Cell Surface Receptor Signaling Pathway Protein Catabolic Process At Postsynapse Negative Regulation Of Lymphangiogenesis Notochord Formation Fasciculation Of Sensory Neuron Axon Regulation Of Cell Adhesion Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Neuron Projection Guidance Axon Guidance Notochord Morphogenesis Pericyte Cell Differentiation Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Cellular Component Organization Lens Fiber Cell Morphogenesis Metallodipeptidase Activity Regulation Of Cell Junction Assembly Tetraspanin-enriched Microdomain Positive Regulation Of CREB Transcription Factor Activity Monocyte Activation Leading Edge Membrane Positive Regulation Of Bicellular Tight Junction Assembly Cell Projection Regulation Of Vasculature Development Pore Complex
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