ZHX1 and ELL

Number of citations of the paper that reports this interaction (PubMedID 12659632)
33

Data Source:
BioGRID (two hybrid)

		ZHX1	ELL
Description		zinc fingers and homeoboxes 1	elongation factor for RNA polymerase II
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Euchromatin Nucleus Nucleoplasm Cytosol Transcription Elongation Factor Complex Cajal Body Nuclear Body Nuclear Speck Histone Locus Body
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding Protein Heterodimerization Activity	Cis-regulatory Region Sequence-specific DNA Binding Protein Binding Phosphatase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cell Differentiation Negative Regulation Of DNA-templated Transcription	In Utero Embryonic Development Transcription Elongation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Elongation By RNA Polymerase II SnRNA Transcription By RNA Polymerase II SnRNA Transcription By RNA Polymerase III Positive Regulation Of Transcription By RNA Polymerase III
Pathways			Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events Transcription-Coupled Nucleotide Excision Repair (TC-NER) TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS			A body shape index ( 34021172) Alanine aminotransferase levels ( 34315874) Alzheimer's disease (late onset) ( 30820047) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 34315874) Breast cancer ( 29059683 23535729) Coronary artery disease ( 29212778) HDL cholesterol levels ( 32203549) Iron status biomarkers (ferritin levels) ( 33536631) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Monocyte count ( 32888494) Pulse pressure ( 30224653) Red blood cell count ( 32888494) Red cell distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494) Waist-hip index ( 34021172)
Interacting Genes		54 interacting genes: AKR1C3 AKT1 ATXN1 BARD1 BCL2L1 BHLHE40 BID CHD3 CREB1 CREBBP CSNK2A1 DDX39B DLST DYNLL1 EFNA2 ELL GADD45A GNG11 GSK3B HSPE1 IDH1 LAMA4 LYAR MPHOSPH6 NACA NFYA PAFAH1B3 PEX14 PIAS4 PIGC PNP PRPF40A PSMD11 SAT1 SERPINB9 SUMO1 SUMO2 TAL1 TALDO1 TARDBP TERF1 TNFRSF10C TOLLIP TP53 UBC UTP3 VIM WDR33 ZBED1 ZHX2 ZHX3 ZMYND11 ZNF33B ZYX	13 interacting genes: EAF1 EAF2 EP300 HDAC3 HNRNPU MCM2 POLR2A SNF8 TFPT TP53 UBC WEE2-AS1 ZHX1
Entrez ID		11244	8178
HPRD ID		10379	02615
Ensembl ID		ENSG00000165156	ENSG00000105656
Uniprot IDs		Q9UKY1	P55199 U3KQ90
PDB IDs		2ECB 2GHF 2LY9 3NAR	2DOA
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleus Nucleoplasm Negative Regulation Of Metabolic Process Nucleic Acid Metabolic Process Negative Regulation Of RNA Metabolic Process PML Body Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Identical Protein Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Rhythmic Process Negative Regulation Of RNA Biosynthetic Process Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein-containing Complex Assembly RNA Metabolic Process Ubiquitin Protein Ligase Binding Negative Regulation Of Protein Localization Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Programmed Cell Death Positive Regulation Of Programmed Cell Death Response To Radiation Regulation Of Release Of Cytochrome C From Mitochondria RNA Binding Positive Regulation Of Metabolic Process Protein Tag Activity Cellular Response To Stress Protein Sumoylation Positive Regulation Of Macromolecule Metabolic Process Response To Stress Regulation Of Macromolecule Metabolic Process Regulation Of Mitochondrion Organization Regulation Of Apoptotic Signaling Pathway DNA Damage Response Regulation Of Mitochondrial Membrane Permeability RNA Polymerase II-specific DNA-binding Transcription Factor Binding SUMO Transferase Activity Protein Binding Regulation Of Cellular Response To Stress	Nucleoplasm Nucleic Acid Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Phosphorus Metabolic Process RNA Metabolic Process Circadian Rhythm Chromatin Remodeling Transcription Elongation By RNA Polymerase II Super Elongation Complex DNA-templated Transcription Elongation Regulation Of Primary Metabolic Process Positive Regulation Of Nucleocytoplasmic Transport Transcription Elongation Factor Activity Regulation Of DNA-templated Transcription Regulation Of Carbohydrate Catabolic Process Regulation Of RNA Biosynthetic Process Nucleus Promoter-specific Chromatin Binding Chromatin Organization Cellular Response To Parathyroid Hormone Stimulus Nucleobase-containing Compound Biosynthetic Process Regulation Of Purine Nucleotide Metabolic Process Regulation Of RNA Metabolic Process Chromatin DNA Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Intracellular Protein Transport Rhythmic Process Random Inactivation Of X Chromosome Epigenetic Regulation Of Gene Expression Regulation Of Transcription Elongation By RNA Polymerase II Response To Parathyroid Hormone Regulation Of Glucose Metabolic Process DNA Binding Regulation Of DNA-templated Transcription Elongation Ubiquitin Protein Ligase Binding Regulation Of Telomere Maintenance Regulation Of Gene Expression Negative Regulation Of Small Molecule Metabolic Process Protein Localization To Organelle Regulation Of DNA Replication Regulation Of Nucleocytoplasmic Transport Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Transcription Elongation Factor Complex Sex-chromosome Dosage Compensation Dosage Compensation By Inactivation Of X Chromosome
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