ZHX1 and HSPE1

Number of citations: 0 (PubMedID 16169070)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		ZHX1	HSPE1
Name		zinc fingers and homeoboxes 1	heat shock protein family E (Hsp10) member 1
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Mitochondrion Mitochondrial Matrix Membrane Extracellular Exosome
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding Protein Heterodimerization Activity	RNA Binding Protein Binding ATP Binding Protein Folding Chaperone Metal Ion Binding Unfolded Protein Binding Protein-folding Chaperone Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cell Differentiation Negative Regulation Of DNA-templated Transcription	Osteoblast Differentiation Protein Folding Response To Unfolded Protein Intrinsic Apoptotic Signaling Pathway
Pathways		None	RHOG GTPase cycle Mitochondrial unfolded protein response (UPRmt)
Drugs		None	Phenethyl Isothiocyanate
GWAS		No GWAS studies recorded	Autism spectrum disorder or schizophrenia ( 28540026 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Schizophrenia ( 25056061 29483656 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 )
Interacting Genes		54 interacting genes: AKR1C3 AKT1 ATXN1 BARD1 BCL2L1 BHLHE40 BID CHD3 CREB1 CREBBP CSNK2A1 DDX39B DLST DYNLL1 EFNA2 ELL GADD45A GNG11 GSK3B HSPE1 IDH1 LAMA4 LYAR MPHOSPH6 NACA NFYA PAFAH1B3 PEX14 PIAS4 PIGC PNP PRPF40A PSMD11 SAT1 SERPINB9 SUMO1 SUMO2 TAL1 TALDO1 TARDBP TERF1 TNFRSF10C TOLLIP TP53 UBC UTP3 VIM WDR33 ZBED1 ZHX2 ZHX3 ZMYND11 ZNF33B ZYX	17 interacting genes: ALDH2 APLP1 CASP3 CRMP1 EEF1A1 ERG28 GBP2 HSPD1 LINC00632 LRIF1 NTAQ1 SAT1 SELENOM STK3 TLE1 UNC119 ZHX1
Entrez ID		11244	3336
HPRD ID		10379	02535
Ensembl ID		ENSG00000165156	ENSG00000115541
Uniprot IDs		Q9UKY1	A0A384N6A4 P61604
PDB IDs		2ECB 2GHF 2LY9 3NAR	4PJ1 6HT7 6MRC 6MRD 8G7N 8G7O
GO Terms Enriched among Interactors		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleus Nucleoplasm Negative Regulation Of Metabolic Process Nucleic Acid Metabolic Process Negative Regulation Of RNA Metabolic Process PML Body Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Identical Protein Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Rhythmic Process Negative Regulation Of RNA Biosynthetic Process Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein-containing Complex Assembly RNA Metabolic Process Ubiquitin Protein Ligase Binding Negative Regulation Of Protein Localization Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Programmed Cell Death Positive Regulation Of Programmed Cell Death Response To Radiation Regulation Of Release Of Cytochrome C From Mitochondria RNA Binding Positive Regulation Of Metabolic Process Protein Tag Activity Cellular Response To Stress Protein Sumoylation Positive Regulation Of Macromolecule Metabolic Process Response To Stress Regulation Of Macromolecule Metabolic Process Regulation Of Mitochondrion Organization Regulation Of Apoptotic Signaling Pathway DNA Damage Response Regulation Of Mitochondrial Membrane Permeability RNA Polymerase II-specific DNA-binding Transcription Factor Binding SUMO Transferase Activity Protein Binding Regulation Of Cellular Response To Stress	Positive Regulation Of Pyroptotic Inflammatory Response