ZHX1 and TERF1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ZHX1	TERF1
Gene Name		zinc fingers and homeoboxes 1	telomeric repeat binding factor (NIMA-interacting) 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Cytoplasm Spindle
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Metal Ion Binding Protein Heterodimerization Activity	DNA Binding Chromatin Binding Double-stranded Telomeric DNA Binding Protein Binding Microtubule Binding DNA Binding, Bending Telomeric DNA Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Cell Differentiation Negative Regulation Of Transcription, DNA-templated	G2/M Transition Of Mitotic Cell Cycle Telomere Maintenance Age-dependent Telomere Shortening Telomere Maintenance Via Telomerase Mitotic Nuclear Division Mitotic Spindle Assembly Checkpoint Negative Regulation Of DNA Replication Positive Regulation Of Microtubule Polymerization Telomeric Loop Formation Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Response To Drug Positive Regulation Of Apoptotic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Mitotic Cell Cycle Protein Homooligomerization Cell Division Negative Regulation Of Telomerase Activity
Pathways			Telomere Maintenance Packaging Of Telomere Ends DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Cellular Senescence Meiotic synapsis
Drugs
Diseases
GWAS			Crohn's disease ( 22412388)
Protein-Protein Interactions		50 interactors: AKR1C3 AKT1 ATXN1 BARD1 BCL2L1 BHLHE40 BID CHD3 CREB1 CSNK2A1 DDX39B DLST DYNLL1 EFNA2 ELL GADD45A GNG11 GSK3B HSPE1 IDH1 LAMA4 LYAR MPHOSPH6 NACA NFYA PAFAH1B3 PEX14 PIAS4 PIGC PNP PRPF40A PSMD11 SAT1 SERPINB9 SUMO2 TAL1 TALDO1 TARDBP TERF1 TNFRSF10C TOLLIP TP53 UTP3 VIM WDR33 ZHX2 ZHX3 ZMYND11 ZNF33B ZYX	200 interactors: ACAT2 ACOT7 ACY1 AFAP1L2 AHCY AK1 AKR1A1 ALDOA AMPD2 AMPH ANXA2 ANXA5 APEX1 ARHGDIA ARPP21 ASS1 ATM BCL7B BIN2 BLM BRAF C12orf43 C19orf66 C1orf35 CALD1 CAPNS1 CASP7 CCDC9 CDC6 CEP85 CFL1 CKB CORO1B CPNE3 CRYBB1 CRYM DBN1 DBNL DCX DDX19B DDX21 DDX23 DDX24 DDX39A DLG5 DNAJB1 DNPH1 DPP3 DPYSL3 EEF1D EIF4B ENO2 EPB41L1 EPHX2 EVL FANCD2 FBP1 FBXO4 FEN1 FES FKBP8 GAMT GAPDH GIT1 GNL3L GNMT GSS HCLS1 HDGFRP2 HEXIM1 HEXIM2 HGD HIST1H1A HMGN3 HMGN4 HMOX1 HNMT HOXA3 HSP90AB1 HSPA6 IPO5 JSRP1 KDM1A KEAP1 KIAA1279 KLHDC4 KPNB1 LASP1 LDHA LDHB LRSAM1 LYAR MAP4 MAP7 MAPK12 MAPRE1 MCM2 MDH1 MSN MT1X MVK NAP1L1 NBN NEFL NME1 NME2 NOL12 NOL3 NUDCD2 NUDT14 NUMA1 NXNL1 OCM2 OGFR PA2G4 PACSIN2 PAFAH1B3 PAGE2 PAICS PAK4 PCP4 PEPD PFKP PFN2 PGD PGLS PGM1 PGM2 PINX1 PKM PNMT POT1 PPM1G PRDX1 PRDX6 PRKCB PTMA PTPN5 RBMY1A1 RECQL4 RIC8A RLIM RNF10 RPAP3 RPL19 RTN3 RTN4 SALL1 SARS SBDS SET SH3BP1 SH3GL2 SH3GL3 SIRPD SKP1 SMAD9 SMARCC2 SNCG SOAT1 SP100 SRM SRSF6 STUB1 SULT1C2 SUPT5H SYK TALDO1 TBC1D10A TBCD TBL1X TCIRG1 TERT THG1L TINAG TINF2 TKT TMSB10 TMSB4Y TNKS TNKS2 TNPO2 TOMM34 TPI1 TRIM16 TRIP10 TRMT1 TUBB2A TUBB3 TUBB4B UTP14A WARS WDR4 WFS1 YWHAG ZBTB16 ZC3H18 ZFP36L1 ZHX1 ZNF790
Entrez ID		11244	7013
HPRD ID		10379	02975
Ensembl ID		ENSG00000165156	ENSG00000147601
Uniprot IDs		Q9UKY1	P54274
PDB IDs		2ECB 2GHF 2LY9 3NAR	1BA5 1H6O 1ITY 1IV6 1W0T 3BQO 3L82
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Cell Death Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cell Death Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Viral Process Regulation Of Mitochondrion Organization Negative Regulation Of Biosynthetic Process Apoptotic Process RNA Metabolic Process Programmed Cell Death Cell Death Death Cellular Metabolic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cell Cycle Gene Expression Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Transcription, DNA-templated Negative Regulation Of Gene Expression Cell Cycle Negative Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Rhythmic Process Negative Regulation Of Cell Cycle Developmental Process Positive Regulation Of Protein Metabolic Process Biosynthetic Process Positive Regulation Of Protein Catabolic Process Cell Cycle Process Regulation Of Cell Cycle Process Regulation Of Proteolysis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Cellular Process Negative Regulation Of Transcription, DNA-templated	Cellular Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Metabolic Process Organelle Organization Heterocycle Metabolic Process Telomere Maintenance Catabolic Process Small Molecule Metabolic Process Cellular Process Pathogenesis Carbohydrate Biosynthetic Process Monosaccharide Metabolic Process Regulation Of Cellular Component Organization Glucose Metabolic Process Carboxylic Acid Metabolic Process Chromosome Organization Biosynthetic Process Organic Acid Metabolic Process Carbohydrate Catabolic Process Nucleobase-containing Small Molecule Metabolic Process Glycolytic Process Ribose Phosphate Metabolic Process Pyruvate Metabolic Process Telomere Maintenance Via Telomere Lengthening Cellular Component Assembly Protein Complex Assembly Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Gluconeogenesis Pentose-phosphate Shunt Glyceraldehyde-3-phosphate Metabolic Process Hexose Metabolic Process Positive Regulation Of Telomere Maintenance Via Telomerase Organophosphate Metabolic Process Hexose Biosynthetic Process Cell Cycle Process Mitotic Cell Cycle Metabolic Process Nucleotide Metabolic Process Regulation Of Organelle Organization Nicotinamide Nucleotide Metabolic Process Pentose Biosynthetic Process Glucose 6-phosphate Metabolic Process Response To Organic Substance Regulation Of Telomere Maintenance Regulation Of DNA Replication NADP Metabolic Process Aromatic Compound Catabolic Process
Tagcloud ?		199a 3p accumulating bound carcinogenesis direct dramatically epigenetic fingers gastric gc homeoboxes inversely involve micrornas mir mirnas n87 nci oncogenic regulator regulators restoring sgc suppressed untranslated upregulated utr zinc	anticancer catalytic cloned compensate division elucidated encoding erosion fusions generally homolog immortality length neoplasms p80 protection repeat repeats repressed ribonucleoprotein telomerase telomere telomeric tep1 terc terf2 tert upregulated withdrawal
Tagcloud (Difference) ?		199a 3p accumulating bound carcinogenesis direct dramatically epigenetic fingers gastric gc homeoboxes inversely involve micrornas mir mirnas n87 nci oncogenic regulator regulators restoring sgc suppressed untranslated utr zinc	anticancer catalytic cloned compensate division elucidated encoding erosion fusions generally homolog immortality length neoplasms p80 protection repeat repeats repressed ribonucleoprotein telomerase telomere telomeric tep1 terc terf2 tert withdrawal
Tagcloud (Intersection) ?		upregulated