ZHX1 and PSMD11

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ZHX1	PSMD11
Description		zinc fingers and homeoboxes 1	proteasome 26S subunit, non-ATPase 11
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Proteasome Complex Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Proteasome Regulatory Particle Proteasome Regulatory Particle, Lid Subcomplex Membrane Proteasome Accessory Complex Protein-containing Complex Secretory Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding Protein Heterodimerization Activity	Structural Molecule Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cell Differentiation Negative Regulation Of DNA-templated Transcription	Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasome Assembly Stem Cell Differentiation
Pathways			Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Neutrophil degranulation Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling KEAP1-NFE2L2 pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Degradation of CDH1 Somitogenesis Antigen processing: Ubiquitination & Proteasome degradation Proteasome assembly Proteasome assembly GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs
Diseases
GWAS			Schizophrenia ( 33169155)
Interacting Genes		54 interacting genes: AKR1C3 AKT1 ATXN1 BARD1 BCL2L1 BHLHE40 BID CHD3 CREB1 CREBBP CSNK2A1 DDX39B DLST DYNLL1 EFNA2 ELL GADD45A GNG11 GSK3B HSPE1 IDH1 LAMA4 LYAR MPHOSPH6 NACA NFYA PAFAH1B3 PEX14 PIAS4 PIGC PNP PRPF40A PSMD11 SAT1 SERPINB9 SUMO1 SUMO2 TAL1 TALDO1 TARDBP TERF1 TNFRSF10C TOLLIP TP53 UBC UTP3 VIM WDR33 ZBED1 ZHX2 ZHX3 ZMYND11 ZNF33B ZYX	38 interacting genes: APP BRD7 CCDC90B CCSER2 CDC42 CEBPA COPS2 COPS6 CRMP1 EEF1A1 EEF1G GAPDH GDF9 HAP1 IGSF21 LRIF1 MED31 NFKB2 PRKAA1 PRKAB2 PRKACA PRMT6 PTN PTPRK RBM48 SETDB1 SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 TLE1 TP53 TUBB2A UNC119 USP4 ZBTB16 ZHX1
Entrez ID		11244	5717
HPRD ID		10379	05119
Ensembl ID		ENSG00000165156	ENSG00000108671
Uniprot IDs		Q9UKY1	O00231
PDB IDs		2ECB 2GHF 2LY9 3NAR	5GJQ 5GJR 5L4K 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 5VGZ 5VHF 5VHH 5VHI 5VHS 6MSB 6MSD 6MSE 6MSG 6MSH 6MSJ 6MSK 6WJD 6WJN 7QXN 7QXP 7QXU 7QXW 7QXX 7QY7 7QYA 7QYB 7W37 7W38 7W39 7W3A 7W3B 7W3C 7W3F 7W3G 7W3H 7W3I 7W3J 7W3K 7W3M 8CVT 8JRI 8JRT 8JTI 8K0G 8USB 8USC 9E8G 9E8H 9E8I 9E8J 9E8K 9E8L 9E8N 9E8O 9E8Q
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleus Nucleoplasm Negative Regulation Of Metabolic Process Nucleic Acid Metabolic Process Negative Regulation Of RNA Metabolic Process PML Body Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Identical Protein Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Rhythmic Process Negative Regulation Of RNA Biosynthetic Process Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein-containing Complex Assembly RNA Metabolic Process Ubiquitin Protein Ligase Binding Negative Regulation Of Protein Localization Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Programmed Cell Death Positive Regulation Of Programmed Cell Death Response To Radiation Regulation Of Release Of Cytochrome C From Mitochondria RNA Binding Positive Regulation Of Metabolic Process Protein Tag Activity Cellular Response To Stress Protein Sumoylation Positive Regulation Of Macromolecule Metabolic Process Response To Stress Regulation Of Macromolecule Metabolic Process Regulation Of Mitochondrion Organization Regulation Of Apoptotic Signaling Pathway DNA Damage Response Regulation Of Mitochondrial Membrane Permeability RNA Polymerase II-specific DNA-binding Transcription Factor Binding SUMO Transferase Activity Protein Binding Regulation Of Cellular Response To Stress	SMAD Protein Complex Heteromeric SMAD Protein Complex Transforming Growth Factor Beta Receptor Signaling Pathway I-SMAD Binding SMAD Protein Signal Transduction Negative Regulation Of Macromolecule Biosynthetic Process Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Embryonic Pattern Specification Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Metabolic Process Cardiac Conduction System Development Cell Surface Receptor Signaling Pathway Transcription Regulator Complex Protein-containing Complex Intracellular Signaling Cassette Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process DEAD/H-box RNA Helicase Binding Regulation Of MiRNA Transcription Chromatin Binding Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Metabolic Process DNA-binding Transcription Factor Activity Regulation Of MiRNA Metabolic Process Nucleotide-activated Protein Kinase Complex Positive Regulation Of Cell Differentiation Ureteric Bud Development Co-SMAD Binding Negative Regulation Of Cell Population Proliferation Regulation Of Cell Differentiation Primary MiRNA Processing Signal Transduction Mesonephric Tubule Development DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Mesonephric Epithelium Development Gastrulation Homomeric SMAD Protein Complex Nucleus Response To Growth Factor Protein Kinase Binding Positive Regulation Of MiRNA Transcription Positive Regulation Of Gene Expression Response To Glucose
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