EIF5B and ECT2

Number of citations of the paper that reports this interaction (PMID 22990118)
7

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		EIF5B	ECT2
Gene Name		eukaryotic translation initiation factor 5B	epithelial cell transforming 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Nucleus Cytoplasm Cytosol Cell-cell Junction Tight Junction Midbody Nuclear Membrane Cleavage Furrow Intracellular Membrane-bounded Organelle Mitotic Spindle Centralspindlin Complex
	Molecular Function	Translation Initiation Factor Activity GTPase Activity Protein Binding GTP Binding Poly(A) RNA Binding	Signal Transducer Activity Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Rho GTPase Binding Protein Homodimerization Activity
	Biological Process	Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process	Cell Morphogenesis Cytokinesis Small GTPase Mediated Signal Transduction Protein Transport Activation Of Protein Kinase Activity Positive Regulation Of Rho GTPase Activity Positive Regulation Of Cytokinesis Activation Of Rho GTPase Activity Activation Of Rac GTPase Activity Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Apoptotic Process Positive Regulation Of Cdc42 GTPase Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Neuron Differentiation Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Protein Homooligomerization Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cellular Response To Hydrogen Peroxide Tight Junction Assembly Cellular Response To Calcium Ion Cellular Response To Ionizing Radiation Apoptotic Signaling Pathway
Pathways		Translation GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Cap-dependent Translation Initiation	Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		9 interactors: BRCA1 CBL CSNK2A1 ECT2 EIF1AX ETS1 PAXIP1 TFCP2 ZBTB3	37 interactors: ABR C2orf42 CCDC91 CD19 CDK1 CHST10 COX2 CRIPAK CSTB EIF4A2 EIF5B ERAL1 F2RL2 FANCM GGN ILVBL KLHL20 MBD1 MT2A NOMO1 NPC2 OOSP2 OTUB1 PARD6A PCOLCE PLK1 POMP PSMA6 RACGAP1 RHOG RPS20 SNRNP200 SPATA22 TCEB1 THAP11 UBB VDAC2
Entrez ID		9669	1894
HPRD ID		07304	11860
Ensembl ID		ENSG00000158417	ENSG00000114346
Uniprot IDs		O60841 Q8N5A0	G5E9L8 Q9H8V3
PDB IDs			3L46
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Histone H3-K4 Methylation Response To Ionizing Radiation Positive Regulation Of Histone Acetylation Regulation Of Cellular Component Organization Regulation Of Histone H3-K4 Methylation Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Protein Acetylation Regulation Of Chromosome Organization Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Histone Methylation Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Histone Acetylation Regulation Of Histone Methylation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Cellular Response To Hydrogen Peroxide Regulation Of Organelle Organization Regulation Of Cell Cycle Positive Regulation Of Histone Modification Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H3-K36 Methylation Positive Regulation Of Histone H4-K16 Acetylation DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Nitrogen Compound Metabolic Process Regulation Of Chromosome Segregation Negative Regulation Of Chromosome Organization Response To Abiotic Stimulus Response To Radiation Negative Regulation Of Cell Cycle Gene Expression Signal Transduction In Response To DNA Damage Regulation Of Metabolic Process Cellular Response To Reactive Oxygen Species Regulation Of Cell Cycle Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Histone H3-K9 Acetylation Transcription, DNA-templated Signal Transduction By P53 Class Mediator RNA Biosynthetic Process Regulation Of Histone Modification Positive Regulation Of Angiogenesis Response To Hydrogen Peroxide Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation	Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Cellular Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Cell Cycle Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Transferase Activity Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process DNA Damage Checkpoint Modification-dependent Protein Catabolic Process Mitotic Cell Cycle Checkpoint Proteolysis Involved In Cellular Protein Catabolic Process Viral Process Cellular Protein Catabolic Process Response To Stress Cellular Response To DNA Damage Stimulus Regulation Of Apoptotic Process Protein Catabolic Process Cellular Response To Stress Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cell Death Positive Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Process Neurotrophin Signaling Pathway Regulation Of Cell Cycle Regulation Of Cellular Protein Metabolic Process Cell Cycle Checkpoint Regulation Of Proteolysis Regulation Of Catalytic Activity Mitotic DNA Damage Checkpoint Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Mitotic DNA Integrity Checkpoint Negative Regulation Of Cell Cycle Negative Regulation Of Protein Ubiquitination Mitotic Cell Cycle Phase Transition Cell Cycle Cell Cycle Phase Transition
Tagcloud ?		40s 60s 80s accordingly configuration cryo distinguished em facilitated facilitates gmppnp gtpase hcv initiator ires joining met peptidyl reconstructions redefines reorientation ribosomal ribosome rotational substates trna trnai universally	broader correlate correlates cytoskeleton dbl dbs deregulated encodes exchange family gtpases guanine jun lfc lsc mpk2 nh2 oncogenes panel possess rho sets specificities structurally transformed transforming utilization versions weakly
Tagcloud (Difference) ?		40s 60s 80s accordingly configuration cryo distinguished em facilitated facilitates gmppnp gtpase hcv initiator ires joining met peptidyl reconstructions redefines reorientation ribosomal ribosome rotational substates trna trnai universally	broader correlate correlates cytoskeleton dbl dbs deregulated encodes exchange family gtpases guanine jun lfc lsc mpk2 nh2 oncogenes panel possess rho sets specificities structurally transformed transforming utilization versions weakly
Tagcloud (Intersection) ?