EIF5B and ETS1

Number of citations of the paper that reports this interaction (PMID 20195357)
18

Data Source:
BioGRID (pull down)

		EIF5B	ETS1
Gene Name		eukaryotic translation initiation factor 5B	v-ets avian erythroblastosis virus E26 oncogene homolog 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Intercellular Bridge
	Molecular Function	Translation Initiation Factor Activity GTPase Activity Protein Binding GTP Binding Poly(A) RNA Binding	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Histone Acetyltransferase Binding Sequence-specific DNA Binding
	Biological Process	Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process	Response To Hypoxia Transcription From RNA Polymerase II Promoter Immune Response Female Pregnancy Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Response To Mechanical Stimulus Positive Regulation Of Endothelial Cell Migration Regulation Of Extracellular Matrix Disassembly Hypothalamus Development Pituitary Gland Development PML Body Organization Response To Estradiol Response To Laminar Fluid Shear Stress Regulation Of Apoptotic Process Positive Regulation Of Erythrocyte Differentiation Regulation Of Angiogenesis Positive Regulation Of Angiogenesis Negative Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Antibiotic Cell Motility Positive Regulation Of Cellular Component Movement Angiogenesis Involved In Wound Healing Cellular Response To Hydrogen Peroxide Response To Interleukin-1
Pathways		Translation GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Cap-dependent Translation Initiation	Cellular Senescence Oncogene Induced Senescence
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972)	Celiac disease ( 20190752) Obesity-related traits ( 23251661) Rheumatoid arthritis ( 22446963) Systemic lupus erythematosus ( 23273568 20169177 19838193)
Protein-Protein Interactions		9 interactors: BRCA1 CBL CSNK2A1 ECT2 EIF1AX ETS1 PAXIP1 TFCP2 ZBTB3	47 interactors: APLP2 APP ARID4B ARL6IP4 ATF2 BRCA1 C17orf62 CAMK2A CAMK2B CREBBP DAXX EIF5B EP300 ETS2 FOS GATA3 HTATIP2 JUN MAF MAPK1 MAPK3 MAPK7 MED23 MEIS1 NCL NCOR1 NFKB1 NR3C1 PAX5 POU1F1 RBBP6 RFWD2 RPL13A RUNX1 RUNX1T1 RUNX2 SMAD3 SP1 SP100 SPI1 SRA1 SRC SRSF11 STAT5B STAT6 TDP2 UBE2I
Entrez ID		9669	2113
HPRD ID		07304	01260
Ensembl ID		ENSG00000158417	ENSG00000134954
Uniprot IDs		O60841 Q8N5A0	A8K725 B4DW78 P14921
PDB IDs			1GVJ 2NNY 2STT 2STW 3MFK 3RI4
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Histone H3-K4 Methylation Response To Ionizing Radiation Positive Regulation Of Histone Acetylation Regulation Of Cellular Component Organization Regulation Of Histone H3-K4 Methylation Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Protein Acetylation Regulation Of Chromosome Organization Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Histone Methylation Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Histone Acetylation Regulation Of Histone Methylation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Cellular Response To Hydrogen Peroxide Regulation Of Organelle Organization Regulation Of Cell Cycle Positive Regulation Of Histone Modification Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H3-K36 Methylation Positive Regulation Of Histone H4-K16 Acetylation DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Nitrogen Compound Metabolic Process Regulation Of Chromosome Segregation Negative Regulation Of Chromosome Organization Response To Abiotic Stimulus Response To Radiation Negative Regulation Of Cell Cycle Gene Expression Signal Transduction In Response To DNA Damage Regulation Of Metabolic Process Cellular Response To Reactive Oxygen Species Regulation Of Cell Cycle Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Histone H3-K9 Acetylation Transcription, DNA-templated Signal Transduction By P53 Class Mediator RNA Biosynthetic Process Regulation Of Histone Modification Positive Regulation Of Angiogenesis Response To Hydrogen Peroxide Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation	Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Gene Expression RNA Metabolic Process Positive Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Metabolic Process Immune System Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Heterocycle Metabolic Process Negative Regulation Of Biosynthetic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Innate Immune Response Biosynthetic Process Developmental Process Cell Differentiation Cellular Metabolic Process Cellular Response To Organic Substance Immune Response Cellular Response To Growth Factor Stimulus Multicellular Organismal Development Response To Growth Factor System Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Abiotic Stimulus Anatomical Structure Development Tissue Development Toll-like Receptor 5 Signaling Pathway
Tagcloud ?		40s 60s 80s accordingly configuration cryo distinguished em facilitated facilitates gmppnp gtpase hcv initiator ires joining met peptidyl reconstructions redefines reorientation ribosomal ribosome rotational substates trna trnai universally	acetate ap1 avian began belong cooperative counterpart differentiate erbb erythroblastosis erythrocytic gata glycoproteins h5 homologues jb jbn jun mammal megakaryocytes megakaryocytic myristate oncogenes phorbol retroviruses thrombocytes thrombocytic transform transformed
Tagcloud (Difference) ?		40s 60s 80s accordingly configuration cryo distinguished em facilitated facilitates gmppnp gtpase hcv initiator ires joining met peptidyl reconstructions redefines reorientation ribosomal ribosome rotational substates trna trnai universally	acetate ap1 avian began belong cooperative counterpart differentiate erbb erythroblastosis erythrocytic gata glycoproteins h5 homologues jb jbn jun mammal megakaryocytes megakaryocytic myristate oncogenes phorbol retroviruses thrombocytes thrombocytic transform transformed
Tagcloud (Intersection) ?