EIF5B and EIF1AX

Number of citations of the paper that reports this interaction (PubMedID 12514125)
36

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		EIF5B	EIF1AX
Description		eukaryotic translation initiation factor 5B	eukaryotic translation initiation factor 1A X-linked
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Synapse	Cytoplasm Cytosol Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Multi-eIF Complex Synapse
	Molecular Function	TRNA Binding Nucleotide Binding RNA Binding Translation Initiation Factor Activity GTPase Activity Protein Binding GTP Binding Hydrolase Activity Metal Ion Binding	TRNA Binding RNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding
	Biological Process	Translation Translational Initiation Regulation Of Translational Initiation Ribosome Assembly	Translation Translational Initiation Ribosome Assembly
Pathways		GTP hydrolysis and joining of the 60S ribosomal subunit	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972)
Interacting Genes		14 interacting genes: BRCA1 CBL CDC42 CEBPA CSNK2A1 ECT2 EIF1AX ETS1 PAXIP1 SIRPA SRSF12 TFCP2 WBP4 ZBTB3	9 interacting genes: APP EIF2S1 EIF3C EIF5 EIF5B HSPB1 IKBKG IPO13 RFPL3
Entrez ID		9669	1964
HPRD ID		07304	02174
Ensembl ID		ENSG00000158417	ENSG00000173674
Uniprot IDs		O60841 Q8N5A0	P47813
PDB IDs		7TQL 8PJ3 8PJ4 8PJ5	1D7Q 3ZJY 4KZY 4KZZ 6YBW 6ZMW 6ZP4 7A09 7QP6 7QP7 7SYQ 7SYR 7SYS 7SYV 7SYW 7SYX 7TQL 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPL
Enriched GO Terms of Interacting Partners?		Response To Ionizing Radiation Regulation Of Cell Cycle Transcription Cis-regulatory Region Binding Nucleic Acid Metabolic Process Negative Regulation Of Cell Cycle Cellular Response To Stress Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Cell Cycle Process Signal Transduction In Response To DNA Damage Nucleobase-containing Compound Metabolic Process Cellular Response To Cytokine Stimulus Positive Regulation Of Endocytosis Response To Radiation Protein Tyrosine Kinase Binding RNA Metabolic Process Positive Regulation Of Cytokinesis Macrophage Differentiation Response To Peptide Response To Cytokine DNA Recombination RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly Histone H2AK127 Ubiquitin Ligase Activity Nucleoplasm Histone H2AK129 Ubiquitin Ligase Activity Macromolecule Metabolic Process Cellular Response To Ionizing Radiation Protein Autoubiquitination BRCA1-BARD1 Complex GBD Domain Binding Storage Vacuole Cellular Response To Type II Interferon Positive Regulation Of DNA-templated Transcription Initiation Response To Vitamin B2 C/EBP Complex MRNA Metabolic Process Cellular Response To Hydrogen Peroxide Cellular Response To Interleukin-12 BRCA1-B Complex Positive Regulation Of Metabolic Process DNA Damage Response Regulation Of RNA Metabolic Process Ubiquitin Protein Ligase Activity Regulation Of Intracellular Signal Transduction Protein-containing Complex Regulation Of Macromolecule Metabolic Process Cellular Response To Tumor Necrosis Factor Positive Regulation Of Developmental Process Intracellular Signal Transduction Regulation Of Transcription By RNA Polymerase II	Translation Initiation Factor Activity Regulation Of Translation Translational Initiation Post-transcriptional Regulation Of Gene Expression Regulation Of Translational Initiation Regulation Of Protein Metabolic Process Cellular Response To Manganese Ion Response To Manganese Ion Translation Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic 48S Preinitiation Complex Ribosome Assembly Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Gene Expression Protein-containing Complex Assembly Regulation Of Macromolecule Biosynthetic Process Cytoplasm Membraneless Organelle Assembly Protein-containing Complex Organization Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Cellular Component Assembly Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Interleukin-1 Beta Production Translation Initiation Ternary Complex RNA Binding Negative Regulation Of Protein Kinase C Signaling Positive Regulation Of Interleukin-1 Production Regulation Of Macromolecule Metabolic Process Ribosome Binding Axo-dendritic Transport Regulation Of Apoptotic Signaling Pathway Synapse Response To Heat Acetylcholine Receptor Activator Activity Regulation Of Response To Endoplasmic Reticulum Stress Lipoprotein Particle Positive Regulation Of Protein Import PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Interleukin-1 Production Positive Regulation Of Tumor Necrosis Factor Production Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Metabolic Process
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