EIF5B

Description		eukaryotic translation initiation factor 5B
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Synapse
	Molecular Function	TRNA Binding Nucleotide Binding RNA Binding Translation Initiation Factor Activity GTPase Activity Protein Binding GTP Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Translation Translational Initiation Regulation Of Translational Initiation Ribosome Assembly
Pathways		GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972)
Interacting Genes		14 interacting genes: BRCA1 CBL CDC42 CEBPA CSNK2A1 ECT2 EIF1AX ETS1 PAXIP1 SIRPA SRSF12 TFCP2 WBP4 ZBTB3
Entrez ID		9669
HPRD ID		07304
Ensembl ID		ENSG00000158417
Uniprot IDs		O60841 Q8N5A0
PDB IDs		7TQL 8PJ3 8PJ4 8PJ5
Enriched GO Terms of Interacting Partners?		Response To Ionizing Radiation Regulation Of Cell Cycle Transcription Cis-regulatory Region Binding Nucleic Acid Metabolic Process Negative Regulation Of Cell Cycle Cellular Response To Stress Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Cell Cycle Process Signal Transduction In Response To DNA Damage Nucleobase-containing Compound Metabolic Process Cellular Response To Cytokine Stimulus Positive Regulation Of Endocytosis Response To Radiation Protein Tyrosine Kinase Binding RNA Metabolic Process Positive Regulation Of Cytokinesis Macrophage Differentiation Response To Peptide Response To Cytokine DNA Recombination RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly Histone H2AK127 Ubiquitin Ligase Activity Nucleoplasm Histone H2AK129 Ubiquitin Ligase Activity Macromolecule Metabolic Process Cellular Response To Ionizing Radiation Protein Autoubiquitination BRCA1-BARD1 Complex GBD Domain Binding Storage Vacuole Cellular Response To Type II Interferon Positive Regulation Of DNA-templated Transcription Initiation Response To Vitamin B2 C/EBP Complex MRNA Metabolic Process Cellular Response To Hydrogen Peroxide Cellular Response To Interleukin-12 BRCA1-B Complex Positive Regulation Of Metabolic Process DNA Damage Response Regulation Of RNA Metabolic Process Ubiquitin Protein Ligase Activity Regulation Of Intracellular Signal Transduction Protein-containing Complex Regulation Of Macromolecule Metabolic Process Cellular Response To Tumor Necrosis Factor Positive Regulation Of Developmental Process Intracellular Signal Transduction Regulation Of Transcription By RNA Polymerase II
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