LSM6 and SMN1

Number of citations of the paper that reports this interaction (PMID 10851237)
37

Data Source:
HPRD (in vitro)

		LSM6	SMN1
Gene Name		LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)	survival of motor neuron 1, telomeric
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Spliceosomal Complex U6 SnRNP Nucleolus Small Nucleolar Ribonucleoprotein Complex Cytosol Small Nuclear Ribonucleoprotein Complex U4/U6 X U5 Tri-snRNP Complex Extracellular Vesicular Exosome	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytosol Cajal Body Z Disc SMN Complex SMN-Sm Protein Complex Gemini Of Coiled Bodies
	Molecular Function	Protein Binding Poly(A) RNA Binding	RNA Binding Protein Binding Identical Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MRNA Splicing, Via Spliceosome TRNA Processing RNA Splicing Gene Expression Maturation Of SSU-rRNA Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay	Spliceosomal Complex Assembly Spliceosomal SnRNP Assembly Nervous System Development Gene Expression NcRNA Metabolic Process
Pathways		mRNA decay by 5' to 3' exoribonuclease Deadenylation-dependent mRNA decay	snRNP Assembly Metabolism of non-coding RNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: APP CLNS1A LSM1 LSM2 LSM3 LSM5 LSM7 LSM8 MCRS1 POLD2 SDCBP SMN1 SNRPD2 SNRPF TARDBP	136 interactors: A1BG A2M ACTB ACTL6B ADAMTS10 AGAP1 APLP1 ARFGAP1 ATP5B ATP6V1A BAG6 BCL2 C19orf60 CARHSP1 CCDC90B CENPB COIL COL4A2 COL4A5 COPS6 CPNE6 CRIP2 CSAD DDAH2 DDX20 DHX9 DMPK DOCK7 DUS2 DYNC1I1 EEF1A1 EIF3G EXT2 EZH2 FAM20C FBL FGB FLAD1 FUBP1 GAPDH GAR1 GDF9 GEMIN2 GEMIN5 GEMIN7 HADHB HIST3H3 HMGXB3 HNRNPR HNRNPU HNRNPUL1 IGHM ILF3 IMMT INPP5K JADE1 KDM1A KIF5A KLHL5 KMT2B KPNB1 LENG8 LRIF1 LSM1 LSM10 LSM11 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 MAST2 MED31 MKI67 MPP1 MRPL37 MSH2 NGFR NKIRAS2 NMT2 OSTF1 PDE4DIP PKM PLXNA3 POLR2A POP7 PSME1 QARS RBBP4 RBBP6 RBFOX2 RBM48 RN7SL1 RNU1-1 RNU2-1 RPL13 RPS2 RXRA SDF4 SEMA5B SETDB1 SMC5 SMN2 SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNUPN SP110 STRAP STXBP2 STXBP3 SULT1A3 SUMO3 SYNCRIP TAF1C TIAL1 TLE1 TMSB4X TP53 TRMT2A TUBA1A TUBB3 UCHL1 UNC119 USP4 WDR18 WDR73 WDYHV1 WIZ ZBTB16 ZNF431 ZRANB2 ZXDC
Entrez ID		11157	6606
HPRD ID		06286	02646
Ensembl ID		ENSG00000164167	ENSG00000172062
Uniprot IDs		P62312	B4DP61 Q16637
PDB IDs			1G5V 1MHN 2LEH 3S6N 4A4E 4A4G 4GLI
Enriched GO Terms of Interacting Partners?		MRNA Processing RNA Splicing MRNA Metabolic Process RNA Processing RNA Splicing, Via Transesterification Reactions Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic MRNA Splicing, Via Spliceosome Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Spliceosomal SnRNP Assembly Nitrogen Compound Metabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Ribonucleoprotein Complex Assembly Aromatic Compound Catabolic Process Ribonucleoprotein Complex Biogenesis Cellular Metabolic Process Histone MRNA Metabolic Process Cellular Macromolecule Catabolic Process NcRNA Metabolic Process Cellular Macromolecular Complex Assembly Cellular Component Assembly Spliceosomal Complex Assembly MRNA 3'-end Processing Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury RNA 3'-end Processing Positive Regulation Of Extracellular Vesicular Exosome Assembly Collateral Sprouting Axon Midline Choice Point Recognition Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Extracellular Vesicular Exosome Assembly Catabolic Process Axon Choice Point Recognition Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Neuron Remodeling Histone MRNA Catabolic Process 3'-UTR-mediated MRNA Stabilization Negative Regulation By Host Of Viral Transcription Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Substrate-dependent Cell Migration, Cell Extension	MRNA Processing RNA Splicing MRNA Metabolic Process RNA Processing RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Metabolic Process Spliceosomal SnRNP Assembly Nucleobase-containing Compound Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Heterocycle Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Ribonucleoprotein Complex Assembly Ribonucleoprotein Complex Biogenesis NcRNA Metabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Cellular Macromolecular Complex Assembly Histone MRNA Metabolic Process Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Cellular Process Nuclear-transcribed MRNA Catabolic Process Posttranscriptional Regulation Of Gene Expression Cellular Component Assembly MRNA Catabolic Process RNA Catabolic Process CRD-mediated MRNA Stabilization Regulation Of Protein Metabolic Process Termination Of RNA Polymerase II Transcription Regulation Of Cellular Protein Metabolic Process DNA-templated Transcription, Termination RNA Biosynthetic Process MRNA 3'-end Processing Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Transcription, DNA-templated RNA 3'-end Processing Regulation Of Mitotic Cell Cycle Phase Transition Spliceosomal Complex Assembly Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Phase Transition Developmental Process Regulation Of Metabolic Process Cellular Macromolecule Catabolic Process Cell Differentiation Catabolic Process
Tagcloud ?		angles arrange assemble building heptameric heteroheptameric hexameric incorporate lsm1 lsm2 lsm23 lsm5 lsm57 lsm657 lsm7 monomers nonetheless plastic pockets preferences pull ring sme smf smg solved spliceosomal	atrophy centromeric compensate copies copy degeneration deletions detectable display donor easily exon fails fatal harbor hindering homozygous infant intragenic italian modifier muscular null predictable sma smn2 splice unusually weakness
Tagcloud (Difference) ?		angles arrange assemble building heptameric heteroheptameric hexameric incorporate lsm1 lsm2 lsm23 lsm5 lsm57 lsm657 lsm7 monomers nonetheless plastic pockets preferences pull ring sme smf smg solved spliceosomal	atrophy centromeric compensate copies copy degeneration deletions detectable display donor easily exon fails fatal harbor hindering homozygous infant intragenic italian modifier muscular null predictable sma smn2 splice unusually weakness
Tagcloud (Intersection) ?