LSM6 and LSM3

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		LSM6	LSM3
Description		LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated	LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
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GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Spliceosomal Complex U6 SnRNP Nucleolus Sno(s)RNA-containing Ribonucleoprotein Complex Cytoplasm Cytosol Small Nuclear Ribonucleoprotein Complex U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Lsm2-8 Complex Ribonucleoprotein Complex	P-body Nucleus Nucleoplasm Spliceosomal Complex U6 SnRNP Cytosol U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome Catalytic Step 2 Spliceosome Lsm2-8 Complex Lsm1-7-Pat1 Complex Ribonucleoprotein Complex
	Molecular Function	RNA Binding Protein Binding Protein Heterodimerization Activity	RNA Binding Protein Binding U6 SnRNA 3'-end Binding
	Biological Process	MRNA Splicing, Via Spliceosome RRNA Processing MRNA Processing MRNA Catabolic Process TRNA Processing RNA Splicing Maturation Of SSU-rRNA	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing P-body Assembly
Pathways		mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway	mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway
Drugs		Uridine Uridine monophosphate Citric acid
Diseases
GWAS		Malaria ( 31844061) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415)	Chronotype ( 30696823) Dilated cardiomyopathy ( 33677556) Dilated cardiomyopathy (MTAG) ( 33495596) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 31562340) Offspring birth weight ( 31043758) PR interval ( 32439900) Red blood cell count ( 32888494)
Interacting Genes		16 interacting genes: APP CEBPA LSM1 LSM2 LSM3 LSM5 LSM7 LSM8 MCRS1 PATL1 POLD2 SDCBP SMN1 SNRPD2 SNRPF TARDBP	45 interacting genes: CCND3 CDKN2D CEP95 CNOT7 DDIT4L DLX4 EEF1A1 EIF4EBP2 EIF4G3 EXOSC1 EXOSC5 GDF9 GSTA1 HSPB1 INCA1 KEAP1 KLF3 LSM1 LSM10 LSM12 LSM2 LSM5 LSM6 LSM7 LSM8 NACC1 PIAS1 QKI SF3B2 SH3GLB2 SMN1 SNRPD3 SNRPE SNRPF SNRPG TCL1A TEPSIN THOC5 TRAPPC2B UTP14A WDR77 WDR83 XPC XRN2 YBX1
Entrez ID		11157	27258
HPRD ID		06286	06283
Ensembl ID		ENSG00000164167	ENSG00000170860
Uniprot IDs		P62312	P62310
PDB IDs		3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 7ABG 8H6E 8H6J 8H6K 8H6L 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5	3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 7ABG 8H6E 8H6J 8H6K 8H6L 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5
Enriched GO Terms of Interacting Partners?		Lsm1-7-Pat1 Complex U4/U6 X U5 Tri-snRNP Complex Lsm2-8 Complex U2-type Precatalytic Spliceosome U6 SnRNP RNA Splicing, Via Transesterification Reactions RNA Splicing MRNA Metabolic Process MRNA Processing Nucleic Acid Metabolic Process RNA Metabolic Process Spliceosomal Complex Nucleobase-containing Compound Metabolic Process MRNA Splicing, Via Spliceosome RNA Processing Ribonucleoprotein Complex Precatalytic Spliceosome RNA Binding Catalytic Step 2 Spliceosome Macromolecule Metabolic Process Spliceosomal SnRNP Assembly MRNA Catabolic Process Nucleus U6 SnRNA Binding SMN-Sm Protein Complex RNA Catabolic Process Nucleoplasm U12-type Spliceosomal Complex P-body Spliceosomal Complex Assembly PICln-Sm Protein Complex Nucleobase-containing Compound Catabolic Process Negative Regulation Of Macromolecule Metabolic Process 7-methylguanosine Cap Hypermethylation Poly(G) Binding Protein-RNA Complex Assembly Negative Regulation Of Gene Expression Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process U4 SnRNP Methylosome Negative Regulation Of Biosynthetic Process Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA P-body Assembly Small Nuclear Ribonucleoprotein Complex MRNA Methylguanosine-cap Decapping Nuclear-transcribed MRNA Catabolic Process U1 SnRNP U5 SnRNP RNA Decapping	RNA Splicing MRNA Metabolic Process MRNA Processing U2-type Precatalytic Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing U4/U6 X U5 Tri-snRNP Complex RNA Binding MRNA Splicing, Via Spliceosome U12-type Spliceosomal Complex RNA Metabolic Process Spliceosomal Complex Nucleic Acid Metabolic Process U7 SnRNP Lsm2-8 Complex Precatalytic Spliceosome U6 SnRNP Spliceosomal SnRNP Assembly Catalytic Step 2 Spliceosome Nucleoplasm Methylosome Ribonucleoprotein Complex Lsm1-7-Pat1 Complex Nucleobase-containing Compound Metabolic Process Small Nuclear Ribonucleoprotein Complex SMN-Sm Protein Complex Nucleus MRNA Catabolic Process RNA Catabolic Process Spliceosomal Complex Assembly 7-methylguanosine Cap Hypermethylation U2-type Prespliceosome Assembly U2 SnRNP U2-type Spliceosomal Complex U4 SnRNP Protein-RNA Complex Assembly Cytoplasm Macromolecule Metabolic Process U1 SnRNP U5 SnRNP Nucleobase-containing Compound Catabolic Process PICln-Sm Protein Complex Spliceosomal Tri-snRNP Complex U2-type Catalytic Step 2 Spliceosome U6 SnRNA Binding P-body RNA Exonuclease Activity Nuclear-transcribed MRNA Catabolic Process Cytosol U7 SnRNA Binding
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