LSM6 and POLD2

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		LSM6	POLD2
Gene Name		LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)	polymerase (DNA directed), delta 2, accessory subunit
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Spliceosomal Complex U6 SnRNP Nucleolus Small Nucleolar Ribonucleoprotein Complex Cytosol Small Nuclear Ribonucleoprotein Complex U4/U6 X U5 Tri-snRNP Complex Extracellular Vesicular Exosome	Nucleus Nucleoplasm
	Molecular Function	Protein Binding Poly(A) RNA Binding	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MRNA Splicing, Via Spliceosome TRNA Processing RNA Splicing Gene Expression Maturation Of SSU-rRNA Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay	Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Telomere Maintenance Via Semi-conservative Replication DNA Biosynthetic Process
Pathways		mRNA decay by 5' to 3' exoribonuclease Deadenylation-dependent mRNA decay	Nucleotide Excision Repair Gap-filling DNA repair synthesis and ligation in TC-NER Extension of Telomeres Repair synthesis for gap-filling by DNA polymerase in TC-NER Leading Strand Synthesis Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) DNA strand elongation Mismatch Repair Polymerase switching Telomere Maintenance Removal of DNA patch containing abasic residue Resolution of Abasic Sites (AP sites) Removal of the Flap Intermediate from the C-strand Base Excision Repair Polymerase switching on the C-strand of the telomere Synthesis of DNA Chromosome Maintenance Lagging Strand Synthesis Processive synthesis on the C-strand of the telomere Processive synthesis on the lagging strand S Phase Telomere C-strand (Lagging Strand) Synthesis Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Removal of the Flap Intermediate Global Genomic NER (GG-NER) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Resolution of AP sites via the multiple-nucleotide patch replacement pathway Transcription-coupled NER (TC-NER)
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: APP CLNS1A LSM1 LSM2 LSM3 LSM5 LSM7 LSM8 MCRS1 POLD2 SDCBP SMN1 SNRPD2 SNRPF TARDBP	16 interactors: CCHCR1 CDK2 CDKN1A EP300 KCTD13 LSM6 PCNA POLD1 POLD3 POLD4 POLDIP2 POLDIP3 SOX12 WRN WRNIP1 XRN1
Entrez ID		11157	5425
HPRD ID		06286	15982
Ensembl ID		ENSG00000164167	ENSG00000106628
Uniprot IDs		P62312	A4D2J4 B2R5S4 P49005
PDB IDs			3E0J
Enriched GO Terms of Interacting Partners?		MRNA Processing RNA Splicing MRNA Metabolic Process RNA Processing RNA Splicing, Via Transesterification Reactions Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic MRNA Splicing, Via Spliceosome Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Spliceosomal SnRNP Assembly Nitrogen Compound Metabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Ribonucleoprotein Complex Assembly Aromatic Compound Catabolic Process Ribonucleoprotein Complex Biogenesis Cellular Metabolic Process Histone MRNA Metabolic Process Cellular Macromolecule Catabolic Process NcRNA Metabolic Process Cellular Macromolecular Complex Assembly Cellular Component Assembly Spliceosomal Complex Assembly MRNA 3'-end Processing Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury RNA 3'-end Processing Positive Regulation Of Extracellular Vesicular Exosome Assembly Collateral Sprouting Axon Midline Choice Point Recognition Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Extracellular Vesicular Exosome Assembly Catabolic Process Axon Choice Point Recognition Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Neuron Remodeling Histone MRNA Catabolic Process 3'-UTR-mediated MRNA Stabilization Negative Regulation By Host Of Viral Transcription Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Substrate-dependent Cell Migration, Cell Extension	DNA Replication DNA Biosynthetic Process DNA Synthesis Involved In DNA Repair Nucleotide-excision Repair, DNA Gap Filling Base-excision Repair Telomere Maintenance Via Semi-conservative Replication Cellular Response To DNA Damage Stimulus Nuclear DNA Replication Telomere Maintenance Via Recombination Telomere Maintenance Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening DNA-dependent DNA Replication Transcription-coupled Nucleotide-excision Repair DNA Repair Mismatch Repair Chromosome Organization Cellular Response To Stress DNA Metabolic Process Mitotic Cell Cycle DNA Recombination Nucleotide-excision Repair Regulation Of DNA Replication Nucleobase-containing Compound Metabolic Process Cell Cycle Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Organelle Organization Regulation Of DNA-dependent DNA Replication Initiation Cell Cycle Response To Stress Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Macromolecule Biosynthetic Process Signal Transduction By P53 Class Mediator G2/M Transition Of Mitotic Cell Cycle Response To UV Positive Regulation Of DNA Metabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Mitochondrion Morphogenesis Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic G1/S Transition Of Mitotic Cell Cycle Cellular Macromolecule Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Biosynthetic Process
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Tagcloud (Difference) ?		angles arrange assemble building heptameric heteroheptameric hexameric incorporate lsm1 lsm2 lsm23 lsm5 lsm57 lsm657 lsm7 monomers nonetheless plastic pockets preferences pull ring sme smf smg solved spliceosomal
Tagcloud (Intersection) ?