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LSM6 and POLD2
Number of citations of the paper that reports this interaction (PMID
15231747
)
44
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
LSM6
POLD2
Gene Name
LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
polymerase (DNA directed), delta 2, accessory subunit
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasmic MRNA Processing Body
Spliceosomal Complex
U6 SnRNP
Nucleolus
Small Nucleolar Ribonucleoprotein Complex
Cytosol
Small Nuclear Ribonucleoprotein Complex
U4/U6 X U5 Tri-snRNP Complex
Extracellular Vesicular Exosome
Nucleus
Nucleoplasm
Molecular Function
Protein Binding
Poly(A) RNA Binding
DNA Binding
DNA-directed DNA Polymerase Activity
Protein Binding
Biological Process
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
MRNA Splicing, Via Spliceosome
TRNA Processing
RNA Splicing
Gene Expression
Maturation Of SSU-rRNA
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Mitotic Cell Cycle
Telomere Maintenance Via Recombination
Telomere Maintenance
DNA Replication
DNA Strand Elongation Involved In DNA Replication
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Base-excision Repair
Nucleotide-excision Repair
Nucleotide-excision Repair, DNA Gap Filling
Mismatch Repair
Telomere Maintenance Via Semi-conservative Replication
DNA Biosynthetic Process
Pathways
mRNA decay by 5' to 3' exoribonuclease
Deadenylation-dependent mRNA decay
Nucleotide Excision Repair
Gap-filling DNA repair synthesis and ligation in TC-NER
Extension of Telomeres
Repair synthesis for gap-filling by DNA polymerase in TC-NER
Leading Strand Synthesis
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
DNA strand elongation
Mismatch Repair
Polymerase switching
Telomere Maintenance
Removal of DNA patch containing abasic residue
Resolution of Abasic Sites (AP sites)
Removal of the Flap Intermediate from the C-strand
Base Excision Repair
Polymerase switching on the C-strand of the telomere
Synthesis of DNA
Chromosome Maintenance
Lagging Strand Synthesis
Processive synthesis on the C-strand of the telomere
Processive synthesis on the lagging strand
S Phase
Telomere C-strand (Lagging Strand) Synthesis
Repair synthesis of patch ~27-30 bases long by DNA polymerase
Cell Cycle, Mitotic
Gap-filling DNA repair synthesis and ligation in GG-NER
Removal of the Flap Intermediate
Global Genomic NER (GG-NER)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway
Transcription-coupled NER (TC-NER)
Drugs
Diseases
GWAS
Protein-Protein Interactions
15 interactors:
APP
CLNS1A
LSM1
LSM2
LSM3
LSM5
LSM7
LSM8
MCRS1
POLD2
SDCBP
SMN1
SNRPD2
SNRPF
TARDBP
16 interactors:
CCHCR1
CDK2
CDKN1A
EP300
KCTD13
LSM6
PCNA
POLD1
POLD3
POLD4
POLDIP2
POLDIP3
SOX12
WRN
WRNIP1
XRN1
Entrez ID
11157
5425
HPRD ID
06286
15982
Ensembl ID
ENSG00000164167
ENSG00000106628
Uniprot IDs
P62312
A4D2J4
B2R5S4
P49005
PDB IDs
3E0J
Enriched GO Terms of Interacting Partners
?
MRNA Processing
RNA Splicing
MRNA Metabolic Process
RNA Processing
RNA Splicing, Via Transesterification Reactions
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic
MRNA Splicing, Via Spliceosome
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
RNA Metabolic Process
Gene Expression
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Spliceosomal SnRNP Assembly
Nitrogen Compound Metabolic Process
Nuclear-transcribed MRNA Catabolic Process
MRNA Catabolic Process
RNA Catabolic Process
Ribonucleoprotein Complex Assembly
Aromatic Compound Catabolic Process
Ribonucleoprotein Complex Biogenesis
Cellular Metabolic Process
Histone MRNA Metabolic Process
Cellular Macromolecule Catabolic Process
NcRNA Metabolic Process
Cellular Macromolecular Complex Assembly
Cellular Component Assembly
Spliceosomal Complex Assembly
MRNA 3'-end Processing
Synaptic Growth At Neuromuscular Junction
Collateral Sprouting In Absence Of Injury
RNA 3'-end Processing
Positive Regulation Of Extracellular Vesicular Exosome Assembly
Collateral Sprouting
Axon Midline Choice Point Recognition
Metabolic Process
Smooth Endoplasmic Reticulum Calcium Ion Homeostasis
Regulation Of Extracellular Vesicular Exosome Assembly
Catabolic Process
Axon Choice Point Recognition
Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA
Neuron Remodeling
Histone MRNA Catabolic Process
3'-UTR-mediated MRNA Stabilization
Negative Regulation By Host Of Viral Transcription
Positive Regulation Of Exosomal Secretion
Regulation Of Exosomal Secretion
Substrate-dependent Cell Migration, Cell Extension
DNA Replication
DNA Biosynthetic Process
DNA Synthesis Involved In DNA Repair
Nucleotide-excision Repair, DNA Gap Filling
Base-excision Repair
Telomere Maintenance Via Semi-conservative Replication
Cellular Response To DNA Damage Stimulus
Nuclear DNA Replication
Telomere Maintenance Via Recombination
Telomere Maintenance
Mitotic Recombination
DNA Strand Elongation Involved In DNA Replication
DNA Strand Elongation
Telomere Maintenance Via Telomere Lengthening
DNA-dependent DNA Replication
Transcription-coupled Nucleotide-excision Repair
DNA Repair
Mismatch Repair
Chromosome Organization
Cellular Response To Stress
DNA Metabolic Process
Mitotic Cell Cycle
DNA Recombination
Nucleotide-excision Repair
Regulation Of DNA Replication
Nucleobase-containing Compound Metabolic Process
Cell Cycle Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Organelle Organization
Regulation Of DNA-dependent DNA Replication Initiation
Cell Cycle
Response To Stress
Nitrogen Compound Metabolic Process
Cellular Macromolecule Biosynthetic Process
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Macromolecule Biosynthetic Process
Signal Transduction By P53 Class Mediator
G2/M Transition Of Mitotic Cell Cycle
Response To UV
Positive Regulation Of DNA Metabolic Process
Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay
Mitochondrion Morphogenesis
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic
G1/S Transition Of Mitotic Cell Cycle
Cellular Macromolecule Catabolic Process
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Biosynthetic Process
Tagcloud
?
angles
arrange
assemble
building
heptameric
heteroheptameric
hexameric
incorporate
lsm1
lsm2
lsm23
lsm5
lsm57
lsm657
lsm7
monomers
nonetheless
plastic
pockets
preferences
pull
ring
sme
smf
smg
solved
spliceosomal
Tagcloud (Difference)
?
angles
arrange
assemble
building
heptameric
heteroheptameric
hexameric
incorporate
lsm1
lsm2
lsm23
lsm5
lsm57
lsm657
lsm7
monomers
nonetheless
plastic
pockets
preferences
pull
ring
sme
smf
smg
solved
spliceosomal
Tagcloud (Intersection)
?