LSM6 and LSM7

Number of citations of the paper that reports this interaction (PubMedID 11920408)
0

Data Source:
HPRD (in vitro)

		LSM6	LSM7
Description		LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated	LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated
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GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Spliceosomal Complex U6 SnRNP Nucleolus Sno(s)RNA-containing Ribonucleoprotein Complex Cytoplasm Cytosol Small Nuclear Ribonucleoprotein Complex U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Lsm2-8 Complex Ribonucleoprotein Complex	Nucleus Nucleoplasm Spliceosomal Complex U6 SnRNP U12-type Spliceosomal Complex Cytosol U4/U6 X U5 Tri-snRNP Complex U2-type Prespliceosome U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome Spliceosomal Tri-snRNP Complex Lsm2-8 Complex Lsm1-7-Pat1 Complex Ribonucleoprotein Complex
	Molecular Function	RNA Binding Protein Binding Protein Heterodimerization Activity	RNA Binding Protein Binding U6 SnRNA Binding
	Biological Process	MRNA Splicing, Via Spliceosome RRNA Processing MRNA Processing MRNA Catabolic Process TRNA Processing RNA Splicing Maturation Of SSU-rRNA	MRNA Splicing, Via Spliceosome Nuclear-transcribed MRNA Catabolic Process MRNA Processing RNA Splicing
Pathways		mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway	mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway
Drugs		Uridine Uridine monophosphate Citric acid
Diseases
GWAS		Malaria ( 31844061) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415)	Parkinson's disease ( 28892059)
Interacting Genes		16 interacting genes: APP CEBPA LSM1 LSM2 LSM3 LSM5 LSM7 LSM8 MCRS1 PATL1 POLD2 SDCBP SMN1 SNRPD2 SNRPF TARDBP	24 interacting genes: CEBPA DDIT4L EPHA2 EXOSC6 EXOSC8 LDB1 LSM1 LSM2 LSM3 LSM5 LSM6 LSM8 MYH13 NPY1R PFKM RAB29 RASSF5 SMN1 SNRPD3 SNRPF SYT17 TACC1 TCL1B ZSCAN26
Entrez ID		11157	51690
HPRD ID		06286	06287
Ensembl ID		ENSG00000164167	ENSG00000130332
Uniprot IDs		P62312	Q9UK45
PDB IDs		3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 7ABG 8H6E 8H6J 8H6K 8H6L 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5	3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 7ABG 8H6E 8H6J 8H6K 8H6L 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5
Enriched GO Terms of Interacting Partners?		Lsm1-7-Pat1 Complex U4/U6 X U5 Tri-snRNP Complex Lsm2-8 Complex U2-type Precatalytic Spliceosome U6 SnRNP RNA Splicing, Via Transesterification Reactions RNA Splicing MRNA Metabolic Process MRNA Processing Nucleic Acid Metabolic Process RNA Metabolic Process Spliceosomal Complex Nucleobase-containing Compound Metabolic Process MRNA Splicing, Via Spliceosome RNA Processing Ribonucleoprotein Complex Precatalytic Spliceosome RNA Binding Catalytic Step 2 Spliceosome Macromolecule Metabolic Process Spliceosomal SnRNP Assembly MRNA Catabolic Process Nucleus U6 SnRNA Binding SMN-Sm Protein Complex RNA Catabolic Process Nucleoplasm U12-type Spliceosomal Complex P-body Spliceosomal Complex Assembly PICln-Sm Protein Complex Nucleobase-containing Compound Catabolic Process Negative Regulation Of Macromolecule Metabolic Process 7-methylguanosine Cap Hypermethylation Poly(G) Binding Protein-RNA Complex Assembly Negative Regulation Of Gene Expression Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process U4 SnRNP Methylosome Negative Regulation Of Biosynthetic Process Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA P-body Assembly Small Nuclear Ribonucleoprotein Complex MRNA Methylguanosine-cap Decapping Nuclear-transcribed MRNA Catabolic Process U1 SnRNP U5 SnRNP RNA Decapping	U4/U6 X U5 Tri-snRNP Complex Lsm2-8 Complex U2-type Precatalytic Spliceosome U6 SnRNP RNA Splicing, Via Transesterification Reactions Lsm1-7-Pat1 Complex MRNA Metabolic Process RNA Splicing MRNA Processing Spliceosomal Complex RNA Processing MRNA Splicing, Via Spliceosome RNA Metabolic Process Precatalytic Spliceosome MRNA Catabolic Process Ribonucleoprotein Complex Nucleobase-containing Compound Metabolic Process RNA Catabolic Process Spliceosomal SnRNP Assembly Nucleobase-containing Compound Catabolic Process Nucleic Acid Metabolic Process Small Nuclear Ribonucleoprotein Complex SMN-Sm Protein Complex RNA Binding Catalytic Step 2 Spliceosome P-body PICln-Sm Protein Complex Spliceosomal Complex Assembly U7 SnRNP 7-methylguanosine Cap Hypermethylation U4 SnRNA 3'-end Processing Nucleolar Exosome (RNase Complex) U4 SnRNP Nuclear MRNA Surveillance Methylosome U6 SnRNA Binding Protein-RNA Complex Assembly Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity RRNA Catabolic Process Nuclear Exosome (RNase Complex) Exosome (RNase Complex) U1 SnRNP Nucleoplasm U5 SnRNP SnRNA 3'-end Processing Nuclear-transcribed MRNA Catabolic Process Macromolecule Catabolic Process U2-type Prespliceosome Assembly U12-type Spliceosomal Complex
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