CHD3 and TP73

Number of citations of the paper that reports this interaction (PubMedID 10961991)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CHD3	TP73
Description		chromodomain helicase DNA binding protein 3	tumor protein p73
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Cytoskeleton NuRD Complex PML Body Centriolar Satellite	Chromatin Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Cytosol Plasma Membrane Cell Junction Ciliary Basal Body
	Molecular Function	Nucleotide Binding Transcription Cis-regulatory Region Binding DNA Binding Chromatin Binding RNA Binding Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Histone Binding Metal Ion Binding ATP-dependent Chromatin Remodeler Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Corepressor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific P53 Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Kinase Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding MDM2/MDM4 Family Protein Binding DNA-binding Transcription Factor Binding Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Spindle Organization Centrosome Cycle Regulation Of Cell Fate Specification Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Regulation Of Stem Cell Differentiation	Kidney Development Release Of Cytochrome C From Mitochondria Mismatch Repair Regulation Of DNA-templated Transcription Apoptotic Process Inflammatory Response DNA Damage Response Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Xenobiotic Stimulus Post-embryonic Development Regulation Of Gene Expression Hippocampus Development Forebrain Development Cerebrospinal Fluid Secretion Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Cell Size Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Morphogenesis Neuron Development Positive Regulation Of Oligodendrocyte Differentiation Protein Tetramerization Regulation Of Cell Cycle Negative Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Lung Ciliated Cell Differentiation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Apoptotic Signaling Pathway
Pathways		HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression SUMOylation of chromatin organization proteins Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Caspase Activators and Caspases TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors RUNX1 regulates transcription of genes involved in differentiation of HSCs
Drugs			Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases			Hepatocellular carcinoma
GWAS		Ischemic stroke ( 26089329) Macular thickness ( 30535121) Prostate cancer ( 29892016) Refractive error ( 32231278) Stroke ( 26089329)	Joint damage in rheumatoid arthritis ( 31596875) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Visceral fat ( 22589738) Waist-hip ratio ( 28552196)
Interacting Genes		101 interacting genes: ACTR1B ADH5 AIMP2 ATP5IF1 BARD1 BCL6 BHLHE40 C4orf17 CASP6 CASP8 CBX4 CPE CRCT1 CREB1 CREBBP CSTF2 CTBP1 CTTN ENTR1 ETV5 FABP4 FBP2 FUBP1 GADD45A GIT1 GPS2 GSK3B HABP4 HSD17B10 HSPH1 HTT IK IKZF1 IKZF3 IMMT IVNS1ABP KIF15 KPNA2 KPNB1 LRIF1 LUC7L2 MAFG MAN2A2 MX1 MYB NEFL NR1H2 NR4A1 PAICS PCMT1 PIAS1 PIAS4 PLK4 PRG2 PRPF40A PSME1 PTN PTPRS PUF60 RAD51 RETREG2 RGS2 RIF1 RNF10 RPL29 SAFB SAT1 SATB1 SERBP1 SERF2 SETX SGSM2 SIRT6 SKIL SLC27A6 SPOP SRRT STIP1 SUMO1 SUMO2 TAL1 TCERG1 THOC7 TNFRSF14 TNNT1 TP53 TP73 TRIM28 TRIM54 TSC22D1 TSPAN6 TTR TXNDC9 UBA3 UBC UBE2I UROD VIM XRCC4 YAE1 ZHX1	64 interacting genes: ABL1 ATF3 AURKA BIN1 BUB1B CABLES1 CCNB1 CCND1 CCNE1 CDK1 CDK2 CEBPZ CHD3 CREBBP CSNK2A1 DAXX DDB1 EP300 FBXO45 FLNA HCK HECW2 HIPK2 HIPK3 HMGB1 HRAS IKBKB ITCH KAT2B MAPK8 MDM2 MDM4 MUL1 MYC NEDD4 NFYB PFDN5 PIAS1 PIN1 PLK1 PML PPP1R13B PRKACB RACK1 RANBP9 RCHY1 RPL11 RPL5 SIRT1 SMAD2 SMAD3 SP1 SP3 STUB1 SUMO1 TP53 TP63 TRIM28 UBE2I UBE3C WT1 WWOX XPO1 YAP1
Entrez ID		1107	7161
HPRD ID		09071	03587
Ensembl ID		ENSG00000170004	ENSG00000078900
Uniprot IDs		A0A8V8TR54 B3KWV4 Q12873 Q2TAZ1	A0A0C4DFW9 O15350
PDB IDs			1COK 1DXS 2KBY 2MPS 2NB1 2WQI 2WQJ 2WTT 2XWC 3VD0 3VD1 3VD2 4A63 4G82 4G83 4GUO 4GUQ 5HOB 5HOC 5KBD 6FGS 6IJQ 7EZJ 8P9C 8P9D 8P9E 9GLQ 9GNB
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus Negative Regulation Of Transcription By RNA Polymerase II Identical Protein Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process SUMO Transferase Activity Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process PML Body Protein Sumoylation Regulation Of DNA-templated Transcription Negative Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Cytoplasm Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Apoptotic Process Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Programmed Cell Death RNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Gene Expression Ubiquitin Protein Ligase Binding Regulation Of Cell Development Presynaptic Cytosol Postsynaptic Cytosol Enzyme Binding Positive Regulation Of Metabolic Process Nucleic Acid Metabolic Process Nuclear Speck Regulation Of Neurogenesis Macromolecule Metabolic Process DNA Repair Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gliogenesis Protein-containing Complex Regulation Of Proteolysis Positive Regulation Of Neuron Apoptotic Process Regulation Of Cellular Response To Stress Regulation Of Cell Differentiation Transcription Corepressor Activity Promoter-specific Chromatin Binding	Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Apoptotic Process Cellular Response To Stress Regulation Of Metabolic Process Positive Regulation Of Metabolic Process DNA Damage Response Protein Modification Process Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Intracellular Signal Transduction Protein Metabolic Process Post-translational Protein Modification Regulation Of Protein Stability Response To Stress Regulation Of Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process PML Body Ubiquitin Protein Ligase Binding Positive Regulation Of RNA Metabolic Process Apoptotic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Enzyme Binding Regulation Of Cellular Component Organization P53 Binding DNA-binding Transcription Factor Binding
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