TP73 and FBXO45

Number of citations of the paper that reports this interaction (PubMedID 19581926)
54

Data Source:
BioGRID (enzymatic study)

		TP73	FBXO45
Description		tumor protein p73	F-box protein 45
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Cytosol Plasma Membrane Cell Junction Ciliary Basal Body	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Membrane SCF Ubiquitin Ligase Complex Presynaptic Membrane Cell Projection Organelle Synapse Postsynaptic Membrane Presynapse Glutamatergic Synapse Presynaptic Cytosol Postsynaptic Cytosol
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Corepressor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific P53 Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Kinase Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding MDM2/MDM4 Family Protein Binding DNA-binding Transcription Factor Binding Promoter-specific Chromatin Binding	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Kidney Development Release Of Cytochrome C From Mitochondria Mismatch Repair Regulation Of DNA-templated Transcription Apoptotic Process Inflammatory Response DNA Damage Response Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Xenobiotic Stimulus Post-embryonic Development Regulation Of Gene Expression Hippocampus Development Forebrain Development Cerebrospinal Fluid Secretion Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Cell Size Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Morphogenesis Neuron Development Positive Regulation Of Oligodendrocyte Differentiation Protein Tetramerization Regulation Of Cell Cycle Negative Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Lung Ciliated Cell Differentiation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Apoptotic Signaling Pathway	Neuron Migration Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Nervous System Development Protein Ubiquitination Cerebral Cortex Radially Oriented Cell Migration Cerebral Cortex Tangential Migration Corticospinal Tract Morphogenesis Anterior Commissure Morphogenesis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innervation Synapse Assembly Involved In Innervation Axon Development Protein K48-linked Ubiquitination Regulation Of Synaptic Vesicle Exocytosis
Pathways		Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Caspase Activators and Caspases TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors RUNX1 regulates transcription of genes involved in differentiation of HSCs
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Hepatocellular carcinoma
GWAS		Joint damage in rheumatoid arthritis ( 31596875) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Visceral fat ( 22589738) Waist-hip ratio ( 28552196)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 30929738 31959851 34103634) Multiple sclerosis ( 31604244) Vitiligo ( 27723757)
Interacting Genes		64 interacting genes: ABL1 ATF3 AURKA BIN1 BUB1B CABLES1 CCNB1 CCND1 CCNE1 CDK1 CDK2 CEBPZ CHD3 CREBBP CSNK2A1 DAXX DDB1 EP300 FBXO45 FLNA HCK HECW2 HIPK2 HIPK3 HMGB1 HRAS IKBKB ITCH KAT2B MAPK8 MDM2 MDM4 MUL1 MYC NEDD4 NFYB PFDN5 PIAS1 PIN1 PLK1 PML PPP1R13B PRKACB RACK1 RANBP9 RCHY1 RPL11 RPL5 SIRT1 SMAD2 SMAD3 SP1 SP3 STUB1 SUMO1 TP53 TP63 TRIM28 UBE2I UBE3C WT1 WWOX XPO1 YAP1	8 interacting genes: FBXW7 PRNP RBX1 SNAI1 SNAI2 TP73 TWIST1 ZEB2
Entrez ID		7161	200933
HPRD ID		03587	19508
Ensembl ID		ENSG00000078900	ENSG00000174013
Uniprot IDs		A0A0C4DFW9 O15350	P0C2W1
PDB IDs		1COK 1DXS 2KBY 2MPS 2NB1 2WQI 2WQJ 2WTT 2XWC 3VD0 3VD1 3VD2 4A63 4G82 4G83 4GUO 4GUQ 5HOB 5HOC 5KBD 6FGS 6IJQ 7EZJ 8P9C 8P9D 8P9E 9GLQ 9GNB
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Apoptotic Process Cellular Response To Stress Regulation Of Metabolic Process Positive Regulation Of Metabolic Process DNA Damage Response Protein Modification Process Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Intracellular Signal Transduction Protein Metabolic Process Post-translational Protein Modification Regulation Of Protein Stability Response To Stress Regulation Of Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process PML Body Ubiquitin Protein Ligase Binding Positive Regulation Of RNA Metabolic Process Apoptotic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Enzyme Binding Regulation Of Cellular Component Organization P53 Binding DNA-binding Transcription Factor Binding	Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Intracellular Signal Transduction Regulation Of Transcription By RNA Polymerase II Ameboidal-type Cell Migration Epithelial Cell Migration Aortic Valve Morphogenesis Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Multicellular Organismal Process Regulation Of Signal Transduction Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Vitamin D Biosynthetic Process Regulation Of Cellular Response To Stress Heart Valve Morphogenesis Regulation Of Intracellular Signal Transduction E-box Binding Regulation Of Cell Communication Regulation Of RNA Metabolic Process Regulation Of Signaling Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Lipid Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Cell Differentiation Epithelial To Mesenchymal Transition Cartilage Morphogenesis Negative Regulation Of Signal Transduction Regulation Of Lipid Metabolic Process Regulation Of Vitamin Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Lipid Metabolic Process Mesenchymal Cell Differentiation Regulation Of Cell Differentiation Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Differentiation Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Osteoblast Differentiation
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