TP73 and DDB1

Number of citations of the paper that reports this interaction (PubMedID 23085759)
0

Data Source:
BioGRID (enzymatic study, affinity chromatography technology)

		TP73	DDB1
Description		tumor protein p73	damage specific DNA binding protein 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Cytosol Plasma Membrane Cell Junction Ciliary Basal Body	Chromosome, Telomeric Region Extracellular Space Nucleus Nucleoplasm Nucleolus Cytoplasm Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Protein-containing Complex Site Of Double-strand Break Extracellular Exosome Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Corepressor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific P53 Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Kinase Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding MDM2/MDM4 Family Protein Binding DNA-binding Transcription Factor Binding Promoter-specific Chromatin Binding	Nucleic Acid Binding DNA Binding Damaged DNA Binding Protein Binding Protein-macromolecule Adaptor Activity Protein-containing Complex Binding WD40-repeat Domain Binding Cullin Family Protein Binding Ubiquitin Ligase Complex Scaffold Activity
	Biological Process	Kidney Development Release Of Cytochrome C From Mitochondria Mismatch Repair Regulation Of DNA-templated Transcription Apoptotic Process Inflammatory Response DNA Damage Response Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Xenobiotic Stimulus Post-embryonic Development Regulation Of Gene Expression Hippocampus Development Forebrain Development Cerebrospinal Fluid Secretion Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Cell Size Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Morphogenesis Neuron Development Positive Regulation Of Oligodendrocyte Differentiation Protein Tetramerization Regulation Of Cell Cycle Negative Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Lung Ciliated Cell Differentiation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Apoptotic Signaling Pathway	DNA Repair Nucleotide-excision Repair Ubiquitin-dependent Protein Catabolic Process Apoptotic Process DNA Damage Response Spindle Assembly Involved In Female Meiosis Proteasomal Protein Catabolic Process Wnt Signaling Pathway Protein Ubiquitination Viral Release From Host Cell Cellular Response To UV Ectopic Germ Cell Programmed Cell Death Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Epigenetic Programming In The Zygotic Pronuclei Positive Regulation Of Viral Genome Replication Positive Regulation Of Gluconeogenesis Positive Regulation Of Protein Catabolic Process Positive Regulation By Virus Of Viral Protein Levels In Host Cell Rhythmic Process Negative Regulation Of Developmental Process Biological Process Involved In Interaction With Symbiont Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Type I Interferon-mediated Signaling Pathway UV-damage Excision Repair Base-excision Repair, AP Site Formation Via Deaminated Base Removal Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Reproductive Process
Pathways		Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Caspase Activators and Caspases TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors RUNX1 regulates transcription of genes involved in differentiation of HSCs	Recognition of DNA damage by PCNA-containing replication complex DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Hepatocellular carcinoma	Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Joint damage in rheumatoid arthritis ( 31596875) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Visceral fat ( 22589738) Waist-hip ratio ( 28552196)
Interacting Genes		64 interacting genes: ABL1 ATF3 AURKA BIN1 BUB1B CABLES1 CCNB1 CCND1 CCNE1 CDK1 CDK2 CEBPZ CHD3 CREBBP CSNK2A1 DAXX DDB1 EP300 FBXO45 FLNA HCK HECW2 HIPK2 HIPK3 HMGB1 HRAS IKBKB ITCH KAT2B MAPK8 MDM2 MDM4 MUL1 MYC NEDD4 NFYB PFDN5 PIAS1 PIN1 PLK1 PML PPP1R13B PRKACB RACK1 RANBP9 RCHY1 RPL11 RPL5 SIRT1 SMAD2 SMAD3 SP1 SP3 STUB1 SUMO1 TP53 TP63 TRIM28 UBE2I UBE3C WT1 WWOX XPO1 YAP1	54 interacting genes: ABL1 ANXA1 BCAS3 BRAP BRWD3 CCNK CDK12 CNOT2 COPS5 CUL4A CUL4B DCAF11 DCAF8 DDB2 DET1 DNMT3A DNMT3B DTL EME1 ERCC8 H1-2 H3C1 HOXD3 IKZF1 IP6K1 LMO4 MEF2A MTA2 MUS81 PIN1 POLH PPDPF PTEN RASSF1 RBBP4 RBBP7 RNF26 SALL2 SHANK3 SIN3A SKP2 SNAI1 STAT1 SUPT3H TBL1X TBL1XR1 TP73 USP40 VAMP3 WDTC1 WIPI2 XPA ZEB2 ZNF277
Entrez ID		7161	1642
HPRD ID		03587	10952
Ensembl ID		ENSG00000078900	ENSG00000167986
Uniprot IDs		A0A0C4DFW9 O15350	Q16531
PDB IDs		1COK 1DXS 2KBY 2MPS 2NB1 2WQI 2WQJ 2WTT 2XWC 3VD0 3VD1 3VD2 4A63 4G82 4G83 4GUO 4GUQ 5HOB 5HOC 5KBD 6FGS 6IJQ 7EZJ 8P9C 8P9D 8P9E 9GLQ 9GNB	2B5L 2B5M 2B5N 2HYE 3E0C 3EI1 3EI2 3EI3 3EI4 3I7H 3I7K 3I7L 3I7N 3I7O 3I7P 3I89 3I8C 3I8E 4A08 4A09 4A0A 4A0B 4A0K 4A0L 4A11 4CI1 4CI2 4CI3 4E54 4E5Z 4TZ4 5FQD 5HXB 5JK7 5V3O 6BN7 6BN8 6BN9 6BNB 6BOY 6DSZ 6FCV 6H0F 6H0G 6PAI 6Q0R 6Q0V 6Q0W 6R8Y 6R8Z 6R90 6R91 6R92 6SJ7 6TD3 6UD7 6UE5 6UML 6XK9 6ZUE 6ZX9 7LPS 7OKQ 7OO3 7OOB 7OOP 7OPC 7OPD 7U8F 7UKN 7V7B 7V7C 7ZN7 7ZNN 8AJM 8AJN 8AJO 8B3D 8B3F 8B3G 8B3I 8BU1 8BU2 8BU3 8BU4 8BU5 8BU6 8BU7 8BU9 8BUA 8BUB 8BUC 8BUD 8BUE 8BUF 8BUG 8BUH 8BUI 8BUJ 8BUK 8BUL 8BUM 8BUN 8BUO 8BUP 8BUQ 8BUR 8BUS 8BUT 8CVP 8D7U 8D7V 8D7W 8D7X 8D7Y 8D7Z 8D80 8D81 8DEY 8G46 8G66 8OIZ 8OJH 8OV6 8QH5 8ROX 8ROY 8T9A 8TL6 8TNP 8TNQ 8TNR 8TZX 8U15 8U16 8U17 8UH6 8WQR 9BBE 9BBG 9BBH 9BBI 9BZ0 9DHD 9DJT 9DJX 9DQD 9EJQ 9ER2 9FD2 9FJX 9FMR
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Apoptotic Process Cellular Response To Stress Regulation Of Metabolic Process Positive Regulation Of Metabolic Process DNA Damage Response Protein Modification Process Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Intracellular Signal Transduction Protein Metabolic Process Post-translational Protein Modification Regulation Of Protein Stability Response To Stress Regulation Of Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process PML Body Ubiquitin Protein Ligase Binding Positive Regulation Of RNA Metabolic Process Apoptotic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Enzyme Binding Regulation Of Cellular Component Organization P53 Binding DNA-binding Transcription Factor Binding	Cul4-RING E3 Ubiquitin Ligase Complex Nucleoplasm Nucleus Regulation Of Transcription By RNA Polymerase II Cul4A-RING E3 Ubiquitin Ligase Complex Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Histone Deacetylase Complex DNA Metabolic Process Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Stress Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process DNA Repair DNA Damage Response Positive Regulation Of Biosynthetic Process Regulation Of Cell Cycle DNA Binding Response To Stress Protein Modification By Small Protein Conjugation Post-translational Protein Modification Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleic Acid Metabolic Process Protein Ubiquitination Regulation Of Mitotic Cell Cycle Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To UV Cul4B-RING E3 Ubiquitin Ligase Complex Regulation Of Cell Fate Specification Negative Regulation Of RNA Metabolic Process Histone Binding Protein Modification Process Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process
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