CHD3 and HSD17B10

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		CHD3	HSD17B10
Gene Name		chromodomain helicase DNA binding protein 3	hydroxysteroid (17-beta) dehydrogenase 10
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome NuRD Complex Intermediate Filament Cytoskeleton	Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Endoplasmic Reticulum Plasma Membrane
	Molecular Function	DNA Binding ATP-dependent DNA Helicase Activity Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Poly(A) RNA Binding	3-hydroxyacyl-CoA Dehydrogenase Activity Protein Binding Cholate 7-alpha-dehydrogenase Activity Testosterone Dehydrogenase [NAD(P)] Activity Poly(A) RNA Binding 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity
	Biological Process	Chromatin Organization Chromatin Assembly Or Disassembly Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Spindle Organization Chromatin Modification DNA Duplex Unwinding Centrosome Organization	Lipid Metabolic Process TRNA Processing Branched-chain Amino Acid Catabolic Process Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process
Pathways		Chromatin modifying enzymes Chromatin organization HDACs deacetylate histones RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance	Branched-chain amino acid catabolism Metabolism of amino acids and derivatives
Drugs			NADH Nicotinamide-Adenine-Dinucleotide 1-Azepan-1-Yl-2-Phenyl-2-(4-Thioxo-1,4-Dihydro-Pyrazolo[3,4-D]Pyrimidin-5-Yl)Ethanone Adduct
Diseases
GWAS
Protein-Protein Interactions		90 interactors: ACTR1B ADH5 AIMP2 ATPIF1 BARD1 BCL6 BHLHE40 C4orf17 CASP6 CASP8 CPE CRCT1 CREB1 CSTF2 CTBP1 CTTN FABP4 FAM134A FBP2 FUBP1 GADD45A GIT1 GPS2 GSK3B HABP4 HSD17B10 HSPH1 HTT IK IKZF1 IKZF3 IMMT IVNS1ABP KIF15 KPNA2 KPNB1 LRIF1 LUC7L2 MAFG MAN2A2 MYB NEFL NR1H2 NR4A1 PAICS PCMT1 PIAS4 PLK4 PRG2 PRPF40A PSME1 PTN PTPRS PUF60 RAD51 RGS2 RIF1 RPL29 SAFB SAT1 SATB1 SDCCAG3 SERBP1 SERF2 SGSM2 SIRT6 SKIL SLC27A6 SRRT SUMO1 SUMO2 TAL1 TCERG1 THOC7 TNFRSF14 TNNT1 TP53 TP73 TRIM28 TSC22D1 TSPAN6 TTR TXNDC9 UBA3 UBE2I UROD VIM XRCC4 YAE1D1 ZHX1	5 interactors: APP CHD3 FAF1 HTRA2 UBE2D1
Entrez ID		1107	3028
HPRD ID		09071	02223
Ensembl ID		ENSG00000170004	ENSG00000072506
Uniprot IDs		B3KWV4 Q12873 Q2TAZ1	Q99714
PDB IDs			1F67 1SO8 1U7T 2O23
Enriched GO Terms of Interacting Partners?		Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Metabolic Process RNA Metabolic Process RNA Biosynthetic Process Transcription, DNA-templated Negative Regulation Of Gene Expression Viral Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Cellular Metabolic Process Negative Regulation Of RNA Biosynthetic Process Gene Expression Negative Regulation Of Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Apoptotic Process Biosynthetic Process Protein Sumoylation Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Death Regulation Of Cellular Process Positive Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cell Cycle Positive Regulation Of Organelle Organization Regulation Of Cell Differentiation Negative Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Regulation Of Gene Expression Positive Regulation Of Programmed Cell Death B Cell Activation Cellular Process Negative Regulation Of Cell Death Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Cell Death Programmed Cell Death Cell Differentiation Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Death Negative Regulation Of Apoptotic Process Death Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Immune System Process	Positive Regulation Of Proteolysis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Cellular Protein Catabolic Process Protein Catabolic Process Regulation Of Multicellular Organism Growth Pentacyclic Triterpenoid Metabolic Process Regulation Of Proteolysis Regulation Of Cellular Protein Metabolic Process Adult Locomotory Behavior Regulation Of Protein Metabolic Process Positive Regulation Of Peptidase Activity Synaptic Growth At Neuromuscular Junction Cellular Macromolecule Catabolic Process Regulation Of Catalytic Activity Adult Behavior Regulation Of Cell Cycle Collateral Sprouting In Absence Of Injury Apoptotic Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Programmed Cell Death Cell Death Death Regulation Of Mitotic Cell Cycle Phase Transition Response To Abiotic Stimulus Regulation Of Cell Cycle Phase Transition Locomotory Behavior Positive Regulation Of Cellular Protein Metabolic Process Collateral Sprouting Axon Midline Choice Point Recognition Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Protein Metabolic Process Axon Choice Point Recognition Cytoplasmic Sequestering Of NF-kappaB Regulation Of Developmental Growth Neuron Remodeling Response To Herbicide Protein Autoprocessing Regulation Of Mitochondrion Degradation Negative Regulation Of Proteolysis Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Negative Regulation Of Protein Processing Proteolysis Positive Regulation Of Catalytic Activity Regulation Of Endopeptidase Activity Regulation Of Protein Catabolic Process Regulation Of Protein Processing Regulation Of Peptidase Activity
Tagcloud ?		ancestor animal arabidopsis atp codes deacetylation exhibits exists mi monomer mononucleosomes multisubunit naked nurd pickle planta promotes remodeler remodelers remodeling restrict retain share ssdna subfamily thaliana trimethylation ubiquitous	10c 17beta abad abnormally abound allopregnanolone alternate avenue belief catalyzes dehydrogenase homotetrameric hydroxysteroid infantile isoleucine misconceptions misnomer missense mistaken multifunctional negligible neuroactive opened predicated properly psychomotor steroids xp11
Tagcloud (Difference) ?		ancestor animal arabidopsis atp codes deacetylation exhibits exists mi monomer mononucleosomes multisubunit naked nurd pickle planta promotes remodeler remodelers remodeling restrict retain share ssdna subfamily thaliana trimethylation ubiquitous	10c 17beta abad abnormally abound allopregnanolone alternate avenue belief catalyzes dehydrogenase homotetrameric hydroxysteroid infantile isoleucine misconceptions misnomer missense mistaken multifunctional negligible neuroactive opened predicated properly psychomotor steroids xp11
Tagcloud (Intersection) ?