TP73 and MAPK8

Number of citations: 66 (PubMedID 15483136)
Data Source: HPRD (in vivo, in vitro)

		TP73	MAPK8
Name		tumor protein p73	mitogen-activated protein kinase 8
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Cytosol Plasma Membrane Cell Junction Ciliary Basal Body	Nucleus Nucleoplasm Cytoplasm Cytosol Axon Synapse Basal Dendrite
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Corepressor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific P53 Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Kinase Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding MDM2/MDM4 Family Protein Binding DNA-binding Transcription Factor Binding Promoter-specific Chromatin Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Enzyme Binding Protein Phosphatase Binding Histone Deacetylase Regulator Activity Histone Deacetylase Binding Protein Serine Kinase Activity Protein Serine/threonine Kinase Binding
	Biological Process	Kidney Development Release Of Cytochrome C From Mitochondria Mismatch Repair Regulation Of DNA-templated Transcription Apoptotic Process Inflammatory Response DNA Damage Response Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Xenobiotic Stimulus Post-embryonic Development Regulation Of Gene Expression Hippocampus Development Forebrain Development Cerebrospinal Fluid Secretion Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Cell Size Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Morphogenesis Neuron Development Positive Regulation Of Oligodendrocyte Differentiation Protein Tetramerization Regulation Of Cell Cycle Negative Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Lung Ciliated Cell Differentiation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Apoptotic Signaling Pathway	MAPK Cascade Double-strand Break Repair Protein Phosphorylation Response To Oxidative Stress JNK Cascade JUN Phosphorylation Response To UV Response To Mechanical Stimulus Positive Regulation Of Gene Expression Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Positive Regulation Of Cyclase Activity Positive Regulation Of Cell Killing Negative Regulation Of Protein Binding Regulation Of Protein Localization Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress Cellular Response To Reactive Oxygen Species Fc-epsilon Receptor Signaling Pathway Regulation Of Circadian Rhythm Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of MRNA Stability NLRP3 Inflammasome Complex Assembly Rhythmic Process Positive Regulation Of Protein Metabolic Process Stress-activated MAPK Cascade MRNA Destabilization Protein Poly-ADP-ribosylation Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Senescence Energy Homeostasis Positive Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Protein Localization To Site Of Double-strand Break
Pathways		Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Caspase Activators and Caspases TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors RUNX1 regulates transcription of genes involved in differentiation of HSCs	Activation of BIM and translocation to mitochondria Activation of BMF and translocation to mitochondria NRAGE signals death through JNK NRAGE signals death through JNK NRIF signals cell death from the nucleus Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Activation of the AP-1 family of transcription factors Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Interleukin-38 signaling WNT5:FZD7-mediated leishmania damping Signaling by ALK fusions and activated point mutants
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Tamoxifen Minocycline Pyrazolanthrone 6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONE 2-({2-[(3-HYDROXYPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)BENZAMIDE N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDE 5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDE 2-fluoro-6-{[2-({2-methoxy-4-[(methylsulfonyl)methyl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide Halicin
Diseases		Hepatocellular carcinoma	None
GWAS		Joint damage in rheumatoid arthritis ( 31596875 ) Visceral adipose tissue adjusted for BMI ( 22589738 ) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738 ) Visceral fat ( 22589738 ) Waist-hip ratio ( 28552196 )	Blood protein levels in cardiovascular risk ( 28369058 ) Daytime sleep phenotypes ( 27126917 ) Opioid dependence (time to event) ( 34124712 ) Refractive error ( 32231278 )
Interacting Genes		64 interacting genes: ABL1 ATF3 AURKA BIN1 BUB1B CABLES1 CCNB1 CCND1 CCNE1 CDK1 CDK2 CEBPZ CHD3 CREBBP CSNK2A1 DAXX DDB1 EP300 FBXO45 FLNA HCK HECW2 HIPK2 HIPK3 HMGB1 HRAS IKBKB ITCH KAT2B MAPK8 MDM2 MDM4 MUL1 MYC NEDD4 NFYB PFDN5 PIAS1 PIN1 PLK1 PML PPP1R13B PRKACB RACK1 RANBP9 RCHY1 RPL11 RPL5 SIRT1 SMAD2 SMAD3 SP1 SP3 STUB1 SUMO1 TP53 TP63 TRIM28 UBE2I UBE3C WT1 WWOX XPO1 YAP1	140 interacting genes: AIMP1 AKT1 APBB2 APLP2 APP ATF2 ATM BAD BCL2 BCL2L1 BCL2L11 BMF BMPR2 CAMP CASP3 CBL CCDC88C CDKN1A CDKN2A CDKN2C CEBPA COPS2 CRK CTNNB1 DUSP1 DUSP10 DUSP16 DUSP22 DUSP4 DUSP7 EEF2K EGFR ELK1 ELK3 ELK4 ELP1 EP300 ETV1 FAM193B FZR1 GANAB GARS1 GEMIN5 GFPT1 GORASP2 GSTP1 GUCY1A1 H2AX HDAC9 HIVEP1 HRAS HSD17B4 HSF1 HSF4 HSPA8 ID2 IL27RA IRAK1 IRF3 IRS1 ITCH JDP2 JKAMP JUN JUNB JUND KRT8 MAP1B MAP2K1 MAP2K2 MAP2K4 MAP2K7 MAP3K2 MAP3K7 MAPK1 MAPK14 MAPK3 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPKAP1 MAPKBP1 MAPT MBP METTL3 MKNK2 MYC NCOA3 NFATC3 NFATC4 NFE2 NFE2L2 NKAPD1 NR3C1 NR4A1 PAX2 PDPK1 PIAS2 PIK3R1 PKMYT1 PNRC1 PPARG PRKD1 PRKDC PXN RAD18 RAF1 RASSF1 RBM15 REL RET RPLP2 RPS6KB1 SCAND1 SCOC SERPINB3 SH3BP5 SHC1 SIRT1 SMAD2 SMAD3 SNCA SNCG SP1 SPAG9 SPI1 SPIB SSU72 STAT3 TFCP2 TNFSF11 TP53 TP73 TRAF6 WDR62 WWOX XRCC6 YWHAZ ZNF219 ZNF605
Entrez ID		7161	5599
HPRD ID		03587	03100
Ensembl ID		ENSG00000078900	ENSG00000107643
Uniprot IDs		A0A0C4DFW9 O15350	A1L4K2 P45983
PDB IDs		1COK 1DXS 2KBY 2MPS 2NB1 2WQI 2WQJ 2WTT 2XWC 3VD0 3VD1 3VD2 4A63 4G82 4G83 4GUO 4GUQ 5HOB 5HOC 5KBD 6FGS 6IJQ 7EZJ 8P9C 8P9D 8P9E 9GLQ 9GNB	1UKH 1UKI 2G01 2GMX 2H96 2NO3 2XRW 2XS0 3ELJ 3O17 3O2M 3PZE 3V3V 3VUD 3VUG 3VUH 3VUI 3VUK 3VUL 3VUM 4AWI 4E73 4G1W 4HYS 4HYU 4IZY 4L7F 4QTD 4UX9 4YR8 5LW1 6F5E 6ZR5 8PT8 8PT9 8PTA 8R5E 8X5M 9FT9
GO Terms Enriched among Interactors		Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Apoptotic Process Cellular Response To Stress Regulation Of Metabolic Process Positive Regulation Of Metabolic Process DNA Damage Response Protein Modification Process Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Intracellular Signal Transduction Protein Metabolic Process Post-translational Protein Modification Regulation Of Protein Stability Response To Stress Regulation Of Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process PML Body Ubiquitin Protein Ligase Binding Positive Regulation Of RNA Metabolic Process Apoptotic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Enzyme Binding Regulation Of Cellular Component Organization P53 Binding DNA-binding Transcription Factor Binding	Intracellular Signal Transduction Intracellular Signaling Cassette Regulation Of Intracellular Signal Transduction Signal Transduction MAPK Cascade Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Response To Stress Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Cellular Response To Stress Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Cellular Developmental Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Population Proliferation Response To Growth Factor Regulation Of Signaling Cellular Response To Oxygen-containing Compound Regulation Of Cell Communication Regulation Of DNA-templated Transcription Positive Regulation Of Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of MAPK Cascade Regulation Of Transcription By RNA Polymerase II Response To Lipid Positive Regulation Of Cell Communication Positive Regulation Of Signaling Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Multicellular Organismal Process Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Signal Transduction Response To Hormone Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Cell Surface Receptor Signaling Pathway Programmed Cell Death Cell Death Regulation Of Cell Differentiation