CHD3 and CBX4

Number of citations of the paper that reports this interaction (PubMedID 27068747)
55

Data Source:
BioGRID (enzymatic study)

		CHD3	CBX4
Description		chromodomain helicase DNA binding protein 3	chromobox 4
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Cytoskeleton NuRD Complex PML Body Centriolar Satellite	Nucleus Nucleoplasm Nuclear Body Nuclear Speck PcG Protein Complex PRC1 Complex
	Molecular Function	Nucleotide Binding Transcription Cis-regulatory Region Binding DNA Binding Chromatin Binding RNA Binding Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Histone Binding Metal Ion Binding ATP-dependent Chromatin Remodeler Activity	Transcription Cis-regulatory Region Binding Chromatin Binding Transcription Corepressor Activity Single-stranded RNA Binding Protein Binding Transferase Activity SUMO Transferase Activity Enzyme Binding SUMO Binding Phosphoprotein Binding SUMO Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Spindle Organization Centrosome Cycle Regulation Of Cell Fate Specification Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Regulation Of Stem Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Protein Sumoylation Negative Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription
Pathways		HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression SUMOylation of chromatin organization proteins Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases
GWAS		Ischemic stroke ( 26089329) Macular thickness ( 30535121) Prostate cancer ( 29892016) Refractive error ( 32231278) Stroke ( 26089329)	Brain morphology (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels) ( 24528284)
Interacting Genes		101 interacting genes: ACTR1B ADH5 AIMP2 ATP5IF1 BARD1 BCL6 BHLHE40 C4orf17 CASP6 CASP8 CBX4 CPE CRCT1 CREB1 CREBBP CSTF2 CTBP1 CTTN ENTR1 ETV5 FABP4 FBP2 FUBP1 GADD45A GIT1 GPS2 GSK3B HABP4 HSD17B10 HSPH1 HTT IK IKZF1 IKZF3 IMMT IVNS1ABP KIF15 KPNA2 KPNB1 LRIF1 LUC7L2 MAFG MAN2A2 MX1 MYB NEFL NR1H2 NR4A1 PAICS PCMT1 PIAS1 PIAS4 PLK4 PRG2 PRPF40A PSME1 PTN PTPRS PUF60 RAD51 RETREG2 RGS2 RIF1 RNF10 RPL29 SAFB SAT1 SATB1 SERBP1 SERF2 SETX SGSM2 SIRT6 SKIL SLC27A6 SPOP SRRT STIP1 SUMO1 SUMO2 TAL1 TCERG1 THOC7 TNFRSF14 TNNT1 TP53 TP73 TRIM28 TRIM54 TSC22D1 TSPAN6 TTR TXNDC9 UBA3 UBC UBE2I UROD VIM XRCC4 YAE1 ZHX1	28 interacting genes: ARID3C CBS CHD3 CREBBP CTBP1 CTBP2 FHL1 H3-3A H3-4 H3C1 H3C14 KMT2A LNX2 MBD1 MED9 MX1 RB1 RING1 RNF2 SATB1 SKIL SPOP STIP1 SUV39H1 TRIM21 UBE2I ZBED1 ZEB2
Entrez ID		1107	8535
HPRD ID		09071	04357
Ensembl ID		ENSG00000170004	ENSG00000141582
Uniprot IDs		A0A8V8TR54 B3KWV4 Q12873 Q2TAZ1	A0A0S2Z5B2 O00257
PDB IDs			2K28 3I8Z 5EPL
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus Negative Regulation Of Transcription By RNA Polymerase II Identical Protein Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process SUMO Transferase Activity Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process PML Body Protein Sumoylation Regulation Of DNA-templated Transcription Negative Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Cytoplasm Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Apoptotic Process Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Programmed Cell Death RNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Gene Expression Ubiquitin Protein Ligase Binding Regulation Of Cell Development Presynaptic Cytosol Postsynaptic Cytosol Enzyme Binding Positive Regulation Of Metabolic Process Nucleic Acid Metabolic Process Nuclear Speck Regulation Of Neurogenesis Macromolecule Metabolic Process DNA Repair Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gliogenesis Protein-containing Complex Regulation Of Proteolysis Positive Regulation Of Neuron Apoptotic Process Regulation Of Cellular Response To Stress Regulation Of Cell Differentiation Transcription Corepressor Activity Promoter-specific Chromatin Binding	Chromatin Remodeling Nucleus Chromatin Organization Negative Regulation Of Transcription By RNA Polymerase II Chromatin Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II PML Body Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Epigenetic Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Primary Metabolic Process RING-like Zinc Finger Domain Binding DNA Binding Chromosome Structural Constituent Of Chromatin Protein-DNA Complex Assembly Zinc Ion Binding Nucleosome Assembly Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Centromere Complex Assembly Nucleosome Transcription Coregulator Binding Identical Protein Binding Sex Chromatin Nucleosome Organization Positive Regulation Of RNA Metabolic Process Heterochromatin Formation Heterochromatin Transcription Coactivator Activity Unmethylated CpG Binding Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Binding Chromatin
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