TP73 and HRAS

Number of citations of the paper that reports this interaction (PMID 16436381)
11

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		TP73	HRAS
Gene Name		tumor protein p73	Harvey rat sarcoma viral oncogene homolog
Image
Gene Ontology Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Factor Complex Golgi Apparatus Cytosol Cell Junction Intracellular Membrane-bounded Organelle	Golgi Membrane Nucleus Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription P53 Binding Chromatin Binding Damaged DNA Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Kinase Binding Identical Protein Binding Transcription Regulatory Region DNA Binding Metal Ion Binding	Protein Binding GTP Binding Protein C-terminus Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Activation Of MAPK Activity Kidney Development Release Of Cytochrome C From Mitochondria Mismatch Repair Transcription From RNA Polymerase II Promoter Inflammatory Response Cellular Response To DNA Damage Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Cell Cycle Arrest Regulation Of Mitotic Cell Cycle Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Post-embryonic Development Response To X-ray Response To Organonitrogen Compound Response To Gamma Radiation Regulation Of Gene Expression Hippocampus Development Mitotic G1 DNA Damage Checkpoint Cerebrospinal Fluid Secretion Cellular Response To UV Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of JUN Kinase Activity Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Differentiation Positive Regulation Of Cell Size Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Digestive Tract Morphogenesis Neuron Development Positive Regulation Of Oligodendrocyte Differentiation Protein Tetramerization Negative Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator	MAPK Cascade Activation Of MAPKK Activity Positive Regulation Of Protein Phosphorylation Endocytosis Chemotaxis Cell Cycle Arrest Mitotic Cell Cycle Checkpoint Signal Transduction Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Synaptic Transmission Axon Guidance Blood Coagulation Cell Proliferation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Visual Learning Fibroblast Growth Factor Receptor Signaling Pathway Organ Morphogenesis Negative Regulation Of Gene Expression Actin Cytoskeleton Organization Positive Regulation Of Cell Migration Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Rac GTPase Activity Negative Regulation Of Rho GTPase Activity Positive Regulation Of Rac Protein Signal Transduction Social Behavior Fc-epsilon Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Negative Regulation Of Cell Differentiation Positive Regulation Of DNA Replication Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JNK Cascade Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Epithelial Cell Proliferation Leukocyte Migration Striated Muscle Cell Differentiation Protein Heterooligomerization Epithelial Tube Branching Involved In Lung Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Wound Healing Cellular Senescence Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Ruffle Assembly Positive Regulation Of Actin Cytoskeleton Reorganization Positive Regulation Of MiRNA Metabolic Process
Pathways			Signaling by the B Cell Receptor (BCR) Signaling by GPCR Signaling by FGFR in disease SHC-mediated cascade MEK activation FCERI mediated MAPK activation CREB phosphorylation through the activation of Ras Signaling by EGFRvIII in Cancer SHC1 events in ERBB2 signaling Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Interleukin receptor SHC signaling Gastrin-CREB signalling pathway via PKC and MAPK p38MAPK events EPH-Ephrin signaling SOS-mediated signalling Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell SHC-mediated signalling Signaling by PDGF DAP12 interactions SHC-related events triggered by IGF1R GRB2 events in EGFR signaling Signaling by ERBB4 Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Signaling by VEGF Signalling to RAS Downstream signal transduction Signaling by FGFR mutants Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling Interleukin-2 signaling Interleukin-3, 5 and GM-CSF signaling Frs2-mediated activation Transmission across Chemical Synapses Ras activation uopn Ca2+ infux through NMDA receptor Adaptive Immune System Signaling by Leptin Signalling to ERKs Prolonged ERK activation events Axon guidance IRS-mediated signalling IGF1R signaling cascade VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling IRS-related events triggered by IGF1R EGFR Transactivation by Gastrin VEGFR2 mediated cell proliferation GRB2 events in ERBB2 signaling Activation of NMDA receptor upon glutamate binding and postsynaptic events RAF phosphorylates MEK Downstream signaling of activated FGFR NCAM signaling for neurite out-growth RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Post NMDA receptor activation events Innate Immune System Signaling by Insulin receptor Signalling by NGF Insulin receptor signalling cascade SOS-mediated signalling SHC-mediated signalling IRS-related events Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer SHC-related events NGF signalling via TRKA from the plasma membrane Tie2 Signaling Signaling by Overexpressed Wild-Type EGFR in Cancer Cell surface interactions at the vascular wall Signaling by FGFR ARMS-mediated activation SHC1 events in EGFR signaling RAF activation IRS-mediated signalling FRS2-mediated cascade Activation of RAS in B cells Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Interleukin receptor SHC signaling Constitutive Signaling by EGFRvIII
Drugs			Hexane-1,6-Diol Trifluoroethanol Guanosine-5\'-Triphosphate Guanosine-5\'-Diphosphate N,N\'-DIMETHYL-N-(ACETYL)-N\'-(7-NITROBENZ-2-OXA-1,3-DIAZOL-4-YL)ETHYLENEDIAMINE
Diseases
GWAS		Visceral adipose tissue adjusted for BMI ( 22589738) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Visceral fat ( 22589738)
Protein-Protein Interactions		50 interactors: ABL1 AURKA BIN1 BUB1B CABLES1 CCNB1 CCND1 CCNE1 CDK1 CDK2 CEBPZ CHD3 CREBBP DAXX EP300 FBXO45 GNB2L1 HECW2 HIPK2 HIPK3 HMGB1 HRAS IKBKB ITCH KAT2B MAPK8 MDM2 MDM4 MYC NEDD4 NFYB PFDN5 PIAS1 PIN1 PML PPP1R13B RANBP9 RBX1 RCHY1 SMAD2 SMAD3 SUMO1 TDG TP53 TP63 UBE2I WT1 WWOX XPO1 YAP1	78 interactors: AGTR1 ARAF ARHGEF1 BCL2 BRAF BRAP CAV1 CDC25A CDC25C DEAF1 DGKZ FNTA FNTB FYN GPSM2 GRB2 GRIN1 GRIN2D ICMT IKZF3 IL3 INSR IRAK1 IRAK2 ITSN1 KRT18 LGALS1 MAP2K1 MAPK8 MLLT4 NF1 PDE6D PDGFB PIK3CA PIK3CD PIK3CG PIK3R1 PLCE1 PRKCI PRKCZ RABAC1 RABGEF1 RAF1 RALA RALGDS RAP1B RAP1GDS1 RAPGEF1 RARRES3 RASA1 RASGRF1 RASGRP1 RASGRP4 RASIP1 RASSF1 RASSF2 RASSF5 RGL1 RGL2 RGL4 RGS12 RHOD RIN1 RIT2 RNF115 SHOC2 SNRPE SNX17 SOS1 SOS2 SRC TIAM1 TLR2 TLR9 TP73 TTC1 VAV1 ZBTB12
Entrez ID		7161	3265
HPRD ID		03587	01813
Ensembl ID		ENSG00000078900	ENSG00000174775
Uniprot IDs		C9J521 O15350	P01112
PDB IDs		1COK 1DXS 2KBY 2WQI 2WQJ 2WTT 2XWC 3VD0 3VD1 3VD2 4A63 4G82 4G83 4GUQ	121P 1AA9 1AGP 1BKD 1CLU 1CRP 1CRQ 1CRR 1CTQ 1GNP 1GNQ 1GNR 1HE8 1IAQ 1IOZ 1JAH 1JAI 1K8R 1LF0 1LF5 1LFD 1NVU 1NVV 1NVW 1NVX 1P2S 1P2T 1P2U 1P2V 1PLJ 1PLK 1PLL 1Q21 1QRA 1RVD 1WQ1 1XCM 1XD2 1XJ0 1ZVQ 1ZW6 221P 2C5L 2CE2 2CL0 2CL6 2CL7 2CLC 2CLD 2EVW 2GDP 2LCF 2LWI 2Q21 2QUZ 2RGA 2RGB 2RGC 2RGD 2RGE 2RGG 2UZI 2VH5 2X1V 3DDC 3I3S 3K8Y 3K9L 3K9N 3KKM 3KKN 3KUD 3L8Y 3L8Z 3LBH 3LBI 3LBN 3LO5 3OIU 3OIV 3OIW 3RRY 3RRZ 3RS0 3RS2 3RS3 3RS4 3RS5 3RS7 3RSL 3RSO 3TGP 421P 4DLR 4DLS 4DLT 4DLU 4DLV 4DLW 4DLX 4DLY 4DLZ 4DST 4DSU 4EFL 4EFM 4EFN 4G0N 4G3X 4K81 4Q21 521P 5P21 621P 6Q21 721P 821P
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cell Cycle Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cell Cycle Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Cellular Protein Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Apoptotic Process Programmed Cell Death Negative Regulation Of Cell Cycle Cell Cycle Process Regulation Of Signal Transduction Cell Death Cellular Response To Stress Death Positive Regulation Of Gene Expression Regulation Of Protein Catabolic Process Regulation Of Apoptotic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Death Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Viral Process Cellular Response To DNA Damage Stimulus Signal Transduction By P53 Class Mediator Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Response To Stress Mitotic Cell Cycle Process Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cell Death Cellular Response To Organic Substance Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Proteolysis Negative Regulation Of Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process	Intracellular Signal Transduction Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Catalytic Activity Neurotrophin Signaling Pathway Signal Transduction Positive Regulation Of Catalytic Activity Neurotrophin TRK Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signaling Cell Communication Small GTPase Mediated Signal Transduction Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Metabolic Process Cellular Response To Stimulus Ras Protein Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Response To Stimulus Positive Regulation Of Intracellular Signal Transduction Regulation Of Ras Protein Signal Transduction Positive Regulation Of Hydrolase Activity Positive Regulation Of Signal Transduction Regulation Of Metabolic Process Cellular Response To Organic Substance Regulation Of GTPase Activity Regulation Of Cellular Process Positive Regulation Of GTPase Activity Response To Organic Substance Positive Regulation Of Ras GTPase Activity Regulation Of Ras GTPase Activity Regulation Of Phosphorylation Platelet Activation Response To Wounding Positive Regulation Of Protein Modification Process Epidermal Growth Factor Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Immune System Process Cell Activation Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Fibroblast Growth Factor Stimulus
Tagcloud ?		acidic amylin calcitonin calcr causally deltan glycolysis iapp implement interplay isoforms lymphomas manipulating p63 pramlintide ramp3 reactivation reprogramming resemble suppressive ta tap63 tap73 therapeutically thymic tp53 tp63 tumours	12th arising arose carcinogenic carrying clustered codon contain detectable epithelium find fraction gaa gga gland indirectly mammary measure methylurea mutants nitroso nmu organ origin preexisting sectors transition untreated
Tagcloud (Difference) ?		acidic amylin calcitonin calcr causally deltan glycolysis iapp implement interplay isoforms lymphomas manipulating p63 pramlintide ramp3 reactivation reprogramming resemble suppressive ta tap63 tap73 therapeutically thymic tp53 tp63 tumours	12th arising arose carcinogenic carrying clustered codon contain detectable epithelium find fraction gaa gga gland indirectly mammary measure methylurea mutants nitroso nmu organ origin preexisting sectors transition untreated
Tagcloud (Intersection) ?