Wiki-Pi
About
Search
People
Updates
Search
TP73 and WT1
Number of citations of the paper that reports this interaction (PubMedID
10744705
)
0
Data Source:
HPRD
(in vivo)
TP73
WT1
Description
tumor protein p73
WT1 transcription factor
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Centrosome
Cytosol
Plasma Membrane
Cell Junction
Ciliary Basal Body
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Nuclear Speck
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Corepressor Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
P53 Binding
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Protein Kinase Binding
Identical Protein Binding
Sequence-specific DNA Binding
Metal Ion Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
MDM2/MDM4 Family Protein Binding
DNA-binding Transcription Factor Binding
Promoter-specific Chromatin Binding
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
RNA Binding
Protein Binding
Zinc Ion Binding
Double-stranded Methylated DNA Binding
Sequence-specific DNA Binding
Hemi-methylated DNA-binding
Metal Ion Binding
C2H2 Zinc Finger Domain Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Kidney Development
Release Of Cytochrome C From Mitochondria
Mismatch Repair
Regulation Of DNA-templated Transcription
Apoptotic Process
Inflammatory Response
DNA Damage Response
Regulation Of Mitotic Cell Cycle
Negative Regulation Of Cell Population Proliferation
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Xenobiotic Stimulus
Post-embryonic Development
Regulation Of Gene Expression
Hippocampus Development
Forebrain Development
Cerebrospinal Fluid Secretion
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Positive Regulation Of MAPK Cascade
Regulation Of Neuron Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Cell Differentiation
Negative Regulation Of Neuron Differentiation
Positive Regulation Of Cell Size
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Digestive Tract Morphogenesis
Neuron Development
Positive Regulation Of Oligodendrocyte Differentiation
Protein Tetramerization
Regulation Of Cell Cycle
Negative Regulation Of Cardiac Muscle Cell Proliferation
Positive Regulation Of Lung Ciliated Cell Differentiation
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Positive Regulation Of Apoptotic Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Vasculogenesis
Ureteric Bud Development
Branching Involved In Ureteric Bud Morphogenesis
Kidney Development
Regulation Of Animal Organ Formation
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Germ Cell Development
Thorax And Anterior Abdomen Determination
Heart Development
Sex Determination
Negative Regulation Of Cell Population Proliferation
RNA Splicing
Gonad Development
Male Gonad Development
Tissue Development
Positive Regulation Of Gene Expression
Negative Regulation Of Translation
Negative Regulation Of Cell Growth
Adrenal Gland Development
Male Genitalia Development
Epithelial Cell Differentiation
Glomerulus Development
Glomerular Basement Membrane Development
Adrenal Cortex Formation
Camera-type Eye Development
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Mesenchymal To Epithelial Transition
Positive Regulation Of Heart Growth
Diaphragm Development
Cardiac Muscle Cell Fate Commitment
Visceral Serous Pericardium Development
Cellular Response To CAMP
Cellular Response To Gonadotropin Stimulus
Metanephric Mesenchyme Development
Nephron Tubule Morphogenesis
Podocyte Differentiation
Posterior Mesonephric Tubule Development
Metanephric Epithelium Development
Metanephric S-shaped Body Morphogenesis
Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation
Circulatory System Development
Positive Regulation Of MiRNA Transcription
Positive Regulation Of Male Gonad Development
Negative Regulation Of Female Gonad Development
Positive Regulation Of Metanephric Ureteric Bud Development
Pathways
Activation of PUMA and translocation to mitochondria
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
TP53 Regulates Transcription of Caspase Activators and Caspases
TP53 Regulates Transcription of Death Receptors and Ligands
Regulation of TP53 Activity through Association with Co-factors
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Transcriptional regulation of testis differentiation
Negative Regulation of CDH1 Gene Transcription
Nephron development
Drugs
Zinc
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
Hepatocellular carcinoma
Nephrotic syndrome and focal segmental glomerulosclerosis
46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS
Joint damage in rheumatoid arthritis (
31596875
)
Visceral adipose tissue adjusted for BMI (
22589738
)
Visceral adipose tissue/subcutaneous adipose tissue ratio (
22589738
)
Visceral fat (
22589738
)
Waist-hip ratio (
28552196
)
Apolipoprotein A1 levels (
32203549
)
Birth weight (
31043758
)
Brugada syndrome (
35210625
)
Coronary artery disease (
33020668
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Endometrial cancer (
30093612
)
Endometrial cancer (endometrioid histology) (
30093612
)
Inguinal hernia (
26686553
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Medication use (diuretics) (
31015401
)
Offspring birth weight (
31043758
)
Pelvic organ prolapse (
32184442
)
PR interval (
32439900
)
Pulse pressure (
30224653
)
Resting-state electroencephalogram vigilance (
29703947
)
Rubella-specific interleukin-6 secretion (
29253144
)
Tuberculosis (
24057671
22306650
)
Uterine fibroids (
31649266
31249589
30194396
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Interacting Genes
64 interacting genes:
ABL1
ATF3
AURKA
BIN1
BUB1B
CABLES1
CCNB1
CCND1
CCNE1
CDK1
CDK2
CEBPZ
CHD3
CREBBP
CSNK2A1
DAXX
DDB1
EP300
FBXO45
FLNA
HCK
HECW2
HIPK2
HIPK3
HMGB1
HRAS
IKBKB
ITCH
KAT2B
MAPK8
MDM2
MDM4
MUL1
MYC
NEDD4
NFYB
PFDN5
PIAS1
PIN1
PLK1
PML
PPP1R13B
PRKACB
RACK1
RANBP9
RCHY1
RPL11
RPL5
SIRT1
SMAD2
SMAD3
SP1
SP3
STUB1
SUMO1
TP53
TP63
TRIM28
UBE2I
UBE3C
WT1
WWOX
XPO1
YAP1
66 interacting genes:
AREG
BHLHE40
CASZ1
CCDC136
CCDC33
CCL5
CEP70
CIAO1
CREBBP
CYSRT1
DIRAS3
DVL2
DVL3
EGR1
ETV7
FAM9B
FHL2
FMR1NB
GLIS2
GOLGA2
HMBOX1
IDI1
IPO8
KLK7
KPNA4
KPNA5
KRT40
KRTAP10-1
KRTAP10-3
KRTAP10-4
KRTAP10-5
KRTAP10-6
KRTAP10-7
KRTAP10-8
KRTAP10-9
LDOC1
MAGEA8
MDM2
MYC
NAT2
NPM3
OGT
OSBPL3
PAWR
PAX2
PICK1
PRKACA
RNASEH2B
SERF2
SOX4
STK11
TAOK1
THAP1
THRSP
TP53
TP63
TP73
TRIM55
TRIM63
U2AF2
UBE2I
WTAP
WTIP
YAP1
ZNF205
ZRANB1
Entrez ID
7161
7490
HPRD ID
03587
06163
Ensembl ID
ENSG00000078900
ENSG00000184937
Uniprot IDs
A0A0C4DFW9
O15350
A0A481V744
H0Y7K5
P19544
Q6PI38
PDB IDs
1COK
1DXS
2KBY
2MPS
2NB1
2WQI
2WQJ
2WTT
2XWC
3VD0
3VD1
3VD2
4A63
4G82
4G83
4GUO
4GUQ
5HOB
5HOC
5KBD
6FGS
6IJQ
7EZJ
8P9C
8P9D
8P9E
9GLQ
9GNB
1XF7
2JP9
2JPA
2PRT
3HPJ
3MYJ
4R2E
4R2P
4R2Q
4R2R
4R2S
4WUU
5KL2
5KL3
5KL4
5KL5
5KL6
5KL7
6B0O
6B0P
6B0Q
6B0R
6BLW
6RSY
6WLH
7BBG
8ISN
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Regulation Of Primary Metabolic Process
Nucleoplasm
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Nucleus
Regulation Of Macromolecule Metabolic Process
Regulation Of Protein Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Programmed Cell Death
Regulation Of Gene Expression
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Apoptotic Process
Cellular Response To Stress
Regulation Of Metabolic Process
Positive Regulation Of Metabolic Process
DNA Damage Response
Protein Modification Process
Negative Regulation Of RNA Metabolic Process
Regulation Of RNA Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Catabolic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of Cell Cycle
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Programmed Cell Death
Negative Regulation Of Apoptotic Process
Intracellular Signal Transduction
Protein Metabolic Process
Post-translational Protein Modification
Regulation Of Protein Stability
Response To Stress
Regulation Of Proteolysis
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
PML Body
Ubiquitin Protein Ligase Binding
Positive Regulation Of RNA Metabolic Process
Apoptotic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Enzyme Binding
Regulation Of Cellular Component Organization
P53 Binding
DNA-binding Transcription Factor Binding
Keratin Filament
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Intermediate Filament
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
P53 Binding
Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Macromolecule Metabolic Process
Transcription Cis-regulatory Region Binding
Nuclear Body
Nucleoplasm
Regulation Of Transcription By RNA Polymerase II
Cellular Response To Gamma Radiation
Cellular Response To Radiation
Chromatin
Identical Protein Binding
Epithelial Cell Proliferation
Regulation Of Stem Cell Population Maintenance
Regulation Of Somatic Stem Cell Population Maintenance
MDM2/MDM4 Family Protein Binding
Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Primary Metabolic Process
Positive Regulation Of Signal Transduction
Cellular Response To UV
Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Cellular Response To Actinomycin D
Cell Population Proliferation
Positive Regulation Of Lymphocyte Apoptotic Process
Nucleus
Regulation Of Intracellular Signal Transduction
Regulation Of Gene Expression
Signal Transduction By P53 Class Mediator
Response To Gamma Radiation
Transcription Factor Binding
Regulation Of Metabolic Process
Regulation Of Signal Transduction
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Positive Regulation Of MiRNA Transcription
Cytosol
Cellular Response To Light Stimulus
Response To Actinomycin D
PML Body
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?