TP73 and HIPK3

Number of citations of the paper that reports this interaction (PubMedID 10961991)
0

Data Source:
BioGRID (two hybrid)

		TP73	HIPK3
Description		tumor protein p73	homeodomain interacting protein kinase 3
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Cytosol Plasma Membrane Cell Junction Ciliary Basal Body	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Nuclear Body PML Body
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Corepressor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific P53 Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Kinase Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding MDM2/MDM4 Family Protein Binding DNA-binding Transcription Factor Binding Promoter-specific Chromatin Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Kidney Development Release Of Cytochrome C From Mitochondria Mismatch Repair Regulation Of DNA-templated Transcription Apoptotic Process Inflammatory Response DNA Damage Response Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Xenobiotic Stimulus Post-embryonic Development Regulation Of Gene Expression Hippocampus Development Forebrain Development Cerebrospinal Fluid Secretion Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Cell Size Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Morphogenesis Neuron Development Positive Regulation Of Oligodendrocyte Differentiation Protein Tetramerization Regulation Of Cell Cycle Negative Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Lung Ciliated Cell Differentiation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Apoptotic Signaling Pathway	Protein Phosphorylation Apoptotic Process MRNA Transcription Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Negative Regulation Of Apoptotic Process Negative Regulation Of JUN Kinase Activity
Pathways		Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Caspase Activators and Caspases TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors RUNX1 regulates transcription of genes involved in differentiation of HSCs
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Fostamatinib
Diseases		Hepatocellular carcinoma
GWAS		Joint damage in rheumatoid arthritis ( 31596875) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Visceral fat ( 22589738) Waist-hip ratio ( 28552196)	Anger ( 24489884) Obese vs. thin ( 30677029) Sleep (1/3-day periodicity) ( 33075057) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		64 interacting genes: ABL1 ATF3 AURKA BIN1 BUB1B CABLES1 CCNB1 CCND1 CCNE1 CDK1 CDK2 CEBPZ CHD3 CREBBP CSNK2A1 DAXX DDB1 EP300 FBXO45 FLNA HCK HECW2 HIPK2 HIPK3 HMGB1 HRAS IKBKB ITCH KAT2B MAPK8 MDM2 MDM4 MUL1 MYC NEDD4 NFYB PFDN5 PIAS1 PIN1 PLK1 PML PPP1R13B PRKACB RACK1 RANBP9 RCHY1 RPL11 RPL5 SIRT1 SMAD2 SMAD3 SP1 SP3 STUB1 SUMO1 TP53 TP63 TRIM28 UBE2I UBE3C WT1 WWOX XPO1 YAP1	37 interacting genes: AR ARRB2 C1QA CREB1 CREBBP DAXX FADD FAS FLNC GLUL GORASP1 GRB2 HEYL HNRNPA1 HNRNPA2B1 HNRNPH1 LIMD1 LIMK2 LIMS2 MBD1 MTMR4 NR2F2 RGS3 SIAH1 SIAH2 SKIL SNIP1 SRSF1 SRSF5 SUMO1 TGFB1I1 TOX4 TP73 TRA2B UBE2I ZNF107 ZYX
Entrez ID		7161	10114
HPRD ID		03587	05111
Ensembl ID		ENSG00000078900	ENSG00000110422
Uniprot IDs		A0A0C4DFW9 O15350	A8KAE4 Q9H422
PDB IDs		1COK 1DXS 2KBY 2MPS 2NB1 2WQI 2WQJ 2WTT 2XWC 3VD0 3VD1 3VD2 4A63 4G82 4G83 4GUO 4GUQ 5HOB 5HOC 5KBD 6FGS 6IJQ 7EZJ 8P9C 8P9D 8P9E 9GLQ 9GNB	7O7I 7O7J
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Apoptotic Process Cellular Response To Stress Regulation Of Metabolic Process Positive Regulation Of Metabolic Process DNA Damage Response Protein Modification Process Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Intracellular Signal Transduction Protein Metabolic Process Post-translational Protein Modification Regulation Of Protein Stability Response To Stress Regulation Of Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process PML Body Ubiquitin Protein Ligase Binding Positive Regulation Of RNA Metabolic Process Apoptotic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Enzyme Binding Regulation Of Cellular Component Organization P53 Binding DNA-binding Transcription Factor Binding	Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Splicing, Via Transesterification Reactions Cytosol Nucleoplasm Regulation Of Gene Expression RNA Splicing Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Protein Kinase B Binding Cell Surface Receptor Signaling Pathway Regulation Of Primary Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Spliceosomal Complex Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Macromolecule Metabolic Process MRNA Splicing, Via Spliceosome Regulation Of Signal Transduction Negative Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleic Acid Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Biosynthetic Process Regulation Of Apoptotic Signaling Pathway RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Catalytic Step 2 Spliceosome MRNA Processing Positive Regulation Of Macromolecule Biosynthetic Process MRNA Metabolic Process Cellular Response To Sodium Arsenite Double-stranded Methylated DNA Binding Small Protein Activating Enzyme Binding Regulation Of RNA Splicing Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Identical Protein Binding
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