PBX2 and RPS6KC1

Number of citations of the paper that reports this interaction (PMID 14667819)
24

Data Source:
HPRD (two hybrid)

		PBX2	RPS6KC1
Gene Name		pre-B-cell leukemia homeobox 2	ribosomal protein S6 kinase, 52kDa, polypeptide 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Factor Complex	Cytoplasm Early Endosome Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Factor Binding Sequence-specific DNA Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Phosphatidylinositol Binding
	Biological Process	Transcription, DNA-templated Proximal/distal Pattern Formation Embryonic Limb Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter	Protein Phosphorylation Signal Transduction
Pathways
Drugs
Diseases
GWAS		Asthma ( 21804548) Crohn's disease ( 23266558) Prostate cancer ( 23535732)
Protein-Protein Interactions		21 interactors: BAIAP2 BLOC1S1 CARD9 CCDC88B CENPBD1 COPS6 DCTN3 HOXA1 HOXA9 HOXB8 IKBKAP MCRS1 NUP62 PBX1 PKNOX1 RPL4 RPS6KC1 SKIV2L2 SMYD3 UBE2E1 ZDHHC7	3 interactors: PBX2 PRDX3 SPHK1
Entrez ID		5089	26750
HPRD ID		08890	10204
Ensembl ID		ENSG00000204304	ENSG00000136643
Uniprot IDs		P40425	F5H7T0 Q96S38
PDB IDs
Enriched GO Terms of Interacting Partners?		Embryonic Skeletal System Development RNA Biosynthetic Process Anterior/posterior Pattern Specification RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Transcription, DNA-templated Cellular Metabolic Process Pattern Specification Process Proximal/distal Pattern Formation Skeletal System Development Abducens Nerve Formation Optokinetic Behavior Immune System Process Peptidyl-lysine Modification Nucleobase-containing Compound Metabolic Process Embryonic Morphogenesis Negative Regulation Of Transferase Activity Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Facial Nucleus Development Organelle Organization Cellular Protein Modification Process Chromatin Organization Negative Regulation Of Myeloid Cell Differentiation Cellular Nitrogen Compound Metabolic Process Viral Transcription Rhombomere 4 Development Semicircular Canal Formation Positive Regulation Of Cellular Metabolic Process Chordate Embryonic Development Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Embryo Development Ending In Birth Or Egg Hatching Regulation Of Nucleic Acid-templated Transcription Rhombomere 3 Development Rhombomere 5 Development Regulation Of RNA Biosynthetic Process Cellular Protein Metabolic Process Histone Modification Cellular Process Regulation Of RNA Metabolic Process Membrane Organization Peptidyl-L-cysteine S-palmitoylation Peptidyl-lysine Acetylation Endomembrane System Organization Embryonic Skeletal System Morphogenesis Nitrogen Compound Metabolic Process	Cellular Response To Reactive Oxygen Species Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Hydrogen Peroxide Sphingoid Catabolic Process Response To Reactive Oxygen Species Cellular Response To Oxidative Stress Peptidyl-cysteine Oxidation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Female Pregnancy Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Oxidation Response To Oxidative Stress Response To Inorganic Substance Sphingosine Metabolic Process Positive Regulation Of Neurotransmitter Secretion Cyclooxygenase Pathway Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Response To Magnesium Ion Hydrogen Peroxide Catabolic Process Prostaglandin Biosynthetic Process Positive Regulation Of NF-kappaB Import Into Nucleus Response To ATP Positive Regulation Of Smooth Muscle Contraction Prostaglandin Metabolic Process Positive Regulation Of Cell Proliferation Sphingolipid Catabolic Process Response To Lipid Membrane Lipid Catabolic Process Regulation Of Mitochondrial Membrane Potential Hydrogen Peroxide Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Transcription Factor Import Into Nucleus Negative Regulation Of Cell Death Regulation Of NF-kappaB Import Into Nucleus Maternal Placenta Development Icosanoid Biosynthetic Process Regulation Of Interleukin-1 Beta Production Proximal/distal Pattern Formation Regulation Of Transcription, DNA-templated Response To Amine Response To Progesterone Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Regulation Of Smooth Muscle Contraction Regulation Of RNA Metabolic Process 'de Novo' Posttranslational Protein Folding Cellular Response To Hydrogen Peroxide
Tagcloud ?		associate buds embryo embryonal embryonic endodermal extended half hox increases limb lives meis mrna mrnas p19 pbx1 pbx1a pbx1b pbx3 pbxs proteasome ra requiring stabilization subtype transcriptionally unspecific	braf cure epha3 exons flt3 glioblastoma glioblastomas gliomagenesis hgg idh1 idh2 mapping mining mutated mutational nras offer opportunities pi3k pik3ca pten rational relapsing sequenced somatic synonymous tgfbr2 tp53 twice
Tagcloud (Difference) ?		associate buds embryo embryonal embryonic endodermal extended half hox increases limb lives meis mrna mrnas p19 pbx1 pbx1a pbx1b pbx3 pbxs proteasome ra requiring stabilization subtype transcriptionally unspecific	braf cure epha3 exons flt3 glioblastoma glioblastomas gliomagenesis hgg idh1 idh2 mapping mining mutated mutational nras offer opportunities pi3k pik3ca pten rational relapsing sequenced somatic synonymous tgfbr2 tp53 twice
Tagcloud (Intersection) ?