PBX2 and DCTN3

Number of citations of the paper that reports this interaction (PMID 14667819)
24

Data Source:
HPRD (two hybrid)

		PBX2	DCTN3
Gene Name		pre-B-cell leukemia homeobox 2	dynactin 3 (p22)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Factor Complex	Condensed Chromosome Kinetochore Centrosome Spindle Cytosol Dynactin Complex Midbody Cleavage Furrow Perinuclear Region Of Cytoplasm
	Molecular Function	Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Factor Binding Sequence-specific DNA Binding	Structural Molecule Activity Protein Binding
	Biological Process	Transcription, DNA-templated Proximal/distal Pattern Formation Embryonic Limb Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Cytokinesis Organelle Organization Microtubule-based Process Mitotic Nuclear Division Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Pathways			Organelle biogenesis and maintenance Assembly of the primary cilium G2/M Transition Anchoring of the basal body to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes MHC class II antigen presentation Centrosome maturation Mitotic G2-G2/M phases Recruitment of mitotic centrosome proteins and complexes Adaptive Immune System
Drugs
Diseases
GWAS		Asthma ( 21804548) Crohn's disease ( 23266558) Prostate cancer ( 23535732)
Protein-Protein Interactions		21 interactors: BAIAP2 BLOC1S1 CARD9 CCDC88B CENPBD1 COPS6 DCTN3 HOXA1 HOXA9 HOXB8 IKBKAP MCRS1 NUP62 PBX1 PKNOX1 RPL4 RPS6KC1 SKIV2L2 SMYD3 UBE2E1 ZDHHC7	4 interactors: ATXN1 DCTN1 GSK3B PBX2
Entrez ID		5089	11258
HPRD ID		08890	06303
Ensembl ID		ENSG00000204304	ENSG00000137100
Uniprot IDs		P40425	O75935
PDB IDs
Enriched GO Terms of Interacting Partners?		Embryonic Skeletal System Development RNA Biosynthetic Process Anterior/posterior Pattern Specification RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Transcription, DNA-templated Cellular Metabolic Process Pattern Specification Process Proximal/distal Pattern Formation Skeletal System Development Abducens Nerve Formation Optokinetic Behavior Immune System Process Peptidyl-lysine Modification Nucleobase-containing Compound Metabolic Process Embryonic Morphogenesis Negative Regulation Of Transferase Activity Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Facial Nucleus Development Organelle Organization Cellular Protein Modification Process Chromatin Organization Negative Regulation Of Myeloid Cell Differentiation Cellular Nitrogen Compound Metabolic Process Viral Transcription Rhombomere 4 Development Semicircular Canal Formation Positive Regulation Of Cellular Metabolic Process Chordate Embryonic Development Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Embryo Development Ending In Birth Or Egg Hatching Regulation Of Nucleic Acid-templated Transcription Rhombomere 3 Development Rhombomere 5 Development Regulation Of RNA Biosynthetic Process Cellular Protein Metabolic Process Histone Modification Cellular Process Regulation Of RNA Metabolic Process Membrane Organization Peptidyl-L-cysteine S-palmitoylation Peptidyl-lysine Acetylation Endomembrane System Organization Embryonic Skeletal System Morphogenesis Nitrogen Compound Metabolic Process	ER-nucleus Signaling Pathway Positive Regulation Of Cellular Metabolic Process Nuclear Export Response To Endoplasmic Reticulum Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Type B Pancreatic Cell Development Superior Temporal Gyrus Development Positive Regulation Of Metabolic Process Re-entry Into Mitotic Cell Cycle Negative Regulation Of Neuron Maturation Hypermethylation Of CpG Island Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Regulation Of Phosphorylation Positive Regulation Of Transcription, DNA-templated Nucleocytoplasmic Transport Nuclear Transport Cellular Response To Interleukin-3 Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Transport Positive Regulation Of Gene Expression Regulation Of Neuron Maturation Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Cellular Biosynthetic Process Protein Localization To Microtubule Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Dendrite Morphogenesis Negative Regulation Of NFAT Protein Import Into Nucleus Negative Regulation Of Phosphorylation ER Overload Response Negative Regulation Of Cardiac Muscle Hypertrophy Multicellular Organismal Development Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Muscle Hypertrophy Regulation Of Glycogen (starch) Synthase Activity Anatomical Structure Development Regulation Of Nitrogen Compound Metabolic Process Establishment Of Localization In Cell Positive Regulation Of Protein Export From Nucleus Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Dendrite Development Developmental Process Regulation Of DNA Methylation Myoblast Fusion Protein Localization To Cytoskeleton Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cellular Localization Regulation Of Gene Expression By Genetic Imprinting
Tagcloud ?		associate buds embryo embryonal embryonic endodermal extended half hox increases limb lives meis mrna mrnas p19 pbx1 pbx1a pbx1b pbx3 pbxs proteasome ra requiring stabilization subtype transcriptionally unspecific
Tagcloud (Difference) ?		associate buds embryo embryonal embryonic endodermal extended half hox increases limb lives meis mrna mrnas p19 pbx1 pbx1a pbx1b pbx3 pbxs proteasome ra requiring stabilization subtype transcriptionally unspecific
Tagcloud (Intersection) ?