PBX2 and HOXC5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PBX2	HOXC5
Description		PBX homeobox 2	homeobox C5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Cell Junction
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding DNA-binding Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Eye Development Regulation Of DNA-templated Transcription Brain Development Animal Organ Morphogenesis Proximal/distal Pattern Formation Embryonic Limb Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Neuron Development	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Anterior/posterior Pattern Specification Embryonic Skeletal System Development
Pathways
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Anxiety ( 33859377) Asthma ( 21804548 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 26876947) Coronary artery disease ( 33020668) Crohn's disease ( 23266558) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Moderate to vigorous physical activity levels ( 29899525) Prostate cancer ( 23535732) Refractive error ( 32231278) Rheumatic heart disease ( 32488134) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172)	A body shape index ( 34021172) Appendicular lean mass ( 33097823) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		38 interacting genes: BAIAP2 BFSP2 BLOC1S1 BLOC1S5 BRMS1L CARD9 CCDC88B CDCA7L CENPBD1P COPS6 DCTN3 EFHC1 ELP1 FAM90A1 HOXA1 HOXA5 HOXA9 HOXB5 HOXB8 HOXC5 HOXC8 HOXC9 MCRS1 MSC MTREX NUP62 PBX1 PKNOX1 PPFIBP1 RIPPLY2 RPL4 RPS6KC1 SMYD3 TTC3 UBE2E1 ZCWPW2 ZDHHC7 ZNF587	11 interacting genes: CTBP2 DVL3 GORASP2 LHX3 LHX4 PBX1 PBX2 PBX4 POLR2G POU6F2 ZBTB16
Entrez ID		5089	3222
HPRD ID		08890	00859
Ensembl ID		ENSG00000204304	ENSG00000172789
Uniprot IDs		A0A024RCR3 P40425	Q00444
PDB IDs
Enriched GO Terms of Interacting Partners?		Anterior/posterior Pattern Specification Embryonic Skeletal System Development Regionalization DNA-binding Transcription Factor Activity Pattern Specification Process Skeletal System Morphogenesis Sequence-specific Double-stranded DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Embryonic Skeletal System Morphogenesis Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process Embryonic Morphogenesis Skeletal System Development RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Embryonic Organ Morphogenesis Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Animal Organ Morphogenesis Proximal/distal Pattern Formation Nucleoplasm Regulation Of Gene Expression Anatomical Structure Morphogenesis Regulation Of Macromolecule Biosynthetic Process Nucleus Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II BLOC-1 Complex Anterograde Synaptic Vesicle Transport DNA Binding Hemopoiesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Myeloid Cell Differentiation	Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Medial Motor Column Neuron Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Chromatin Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coregulator Binding Positive Regulation Of Transcription By RNA Polymerase II Transcription Corepressor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Animal Organ Morphogenesis Positive Regulation Of Metabolic Process Regulation Of Gene Expression Embryonic Limb Morphogenesis Regionalization DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process DNA-binding Transcription Factor Activity Limb Morphogenesis RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Eye Development Cellular Developmental Process Regulation Of Macromolecule Metabolic Process Pattern Specification Process DNA Binding Animal Organ Development Anatomical Structure Morphogenesis Motor Neuron Axon Guidance Embryonic Organ Development Proximal/distal Pattern Formation Sequence-specific DNA Binding Sensory Organ Development Neuron Development DNA-binding Transcription Factor Binding Regulation Of Metabolic Process Cell Differentiation In Spinal Cord Placenta Development Brain Development Transcription Regulator Complex Developmental Process Transcription Repressor Complex
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?