PBX2 and HOXB8

Number of citations of the paper that reports this interaction (PubMedID 11438208)
0

Data Source:
HPRD (in vitro, in vivo)

		PBX2	HOXB8
Description		PBX homeobox 2	homeobox B8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding DNA-binding Transcription Factor Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Eye Development Regulation Of DNA-templated Transcription Brain Development Animal Organ Morphogenesis Proximal/distal Pattern Formation Embryonic Limb Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Neuron Development	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Grooming Behavior Adult Locomotory Behavior Anterior/posterior Pattern Specification Sensory Perception Of Pain Dorsal Spinal Cord Development Negative Regulation Of Myeloid Cell Differentiation Embryonic Skeletal System Morphogenesis Skeletal System Morphogenesis
Pathways
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Anxiety ( 33859377) Asthma ( 21804548 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 26876947) Coronary artery disease ( 33020668) Crohn's disease ( 23266558) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Moderate to vigorous physical activity levels ( 29899525) Prostate cancer ( 23535732) Refractive error ( 32231278) Rheumatic heart disease ( 32488134) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172)
Interacting Genes		38 interacting genes: BAIAP2 BFSP2 BLOC1S1 BLOC1S5 BRMS1L CARD9 CCDC88B CDCA7L CENPBD1P COPS6 DCTN3 EFHC1 ELP1 FAM90A1 HOXA1 HOXA5 HOXA9 HOXB5 HOXB8 HOXC5 HOXC8 HOXC9 MCRS1 MSC MTREX NUP62 PBX1 PKNOX1 PPFIBP1 RIPPLY2 RPL4 RPS6KC1 SMYD3 TTC3 UBE2E1 ZCWPW2 ZDHHC7 ZNF587	5 interacting genes: MEIS1 OTUD3 PBX1 PBX2 PBX3
Entrez ID		5089	3218
HPRD ID		08890	00851
Ensembl ID		ENSG00000204304	ENSG00000120068
Uniprot IDs		A0A024RCR3 P40425	P17481 Q8N8T3
PDB IDs
Enriched GO Terms of Interacting Partners?		Anterior/posterior Pattern Specification Embryonic Skeletal System Development Regionalization DNA-binding Transcription Factor Activity Pattern Specification Process Skeletal System Morphogenesis Sequence-specific Double-stranded DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Embryonic Skeletal System Morphogenesis Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process Embryonic Morphogenesis Skeletal System Development RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Embryonic Organ Morphogenesis Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Animal Organ Morphogenesis Proximal/distal Pattern Formation Nucleoplasm Regulation Of Gene Expression Anatomical Structure Morphogenesis Regulation Of Macromolecule Biosynthetic Process Nucleus Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II BLOC-1 Complex Anterograde Synaptic Vesicle Transport DNA Binding Hemopoiesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Myeloid Cell Differentiation	Eye Development Sensory Organ Development Transcription Regulator Complex Brain Development Pattern Specification Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Animal Organ Morphogenesis Embryonic Organ Development Neuron Development Proximal/distal Pattern Formation Cell Development Regionalization Regulation Of Transcription By RNA Polymerase II Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Sequence-specific DNA Binding Regulation Of RNA Biosynthetic Process Animal Organ Development Negative Regulation Of Neuron Differentiation Anatomical Structure Morphogenesis Embryonic Limb Morphogenesis Posterior Compartment Specification Anterior Compartment Pattern Formation Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Limb Morphogenesis Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein K6-linked Deubiquitination Anterior/posterior Pattern Specification DNA Binding Hemopoiesis DNA-binding Transcription Factor Binding Compartment Pattern Specification Protein K27-linked Deubiquitination Locomotory Behavior Regulation Of Neuron Differentiation Dorsal Spinal Cord Development Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Cell Growth Involved In Cardiac Muscle Cell Development
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