NEDD8 and N4BP1

Number of citations of the paper that reports this interaction (PubMedID 30659753)
0

Data Source:
BioGRID (pull down)

		NEDD8	N4BP1
Description		NEDD8 ubiquitin like modifier	NEDD4 binding protein 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Exosome Postsynapse Glutamatergic Synapse	Nucleus Nucleolus Cytoplasm Cytosol PML Body
	Molecular Function	Protein Binding Protein Tag Activity Ubiquitin Protein Ligase Binding	RNA Binding MRNA Binding Nuclease Activity RNA Nuclease Activity Protein Binding Hydrolase Activity Ubiquitin Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Proteolysis Ubiquitin-dependent Protein Catabolic Process Intracellular Protein Localization Anatomical Structure Morphogenesis Protein Ubiquitination Modification-dependent Protein Catabolic Process Regulation Of Proteolysis Protein Modification Process Protein Neddylation Cellular Response To Camptothecin Regulation Of Postsynapse Assembly	Negative Regulation Of Cytokine Production Immune System Process Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To UV Negative Regulation Of Viral Genome Replication Innate Immune Response Regulation Of Innate Immune Response
Pathways		TGF-beta receptor signaling activates SMADs UCH proteinases Cargo recognition for clathrin-mediated endocytosis Neddylation Iron uptake and transport	Regulation of NF-kappa B signaling
Drugs
Diseases
GWAS		Mean corpuscular volume ( 29403010) Systolic blood pressure (cigarette smoking interaction) ( 26752167)	Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Neutrophil percentage of granulocytes ( 27863252) Serum metabolite levels ( 33031748) Social autistic-like traits ( 24133439) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		71 interacting genes: AHR ANKRD13D ARIH2 ATXN3 BAG3 CBLB CDC34 COPS5 COPS6 CTRC CUL1 CUL2 CUL3 CUL4B DNAJA2 DNAJB2 DNMT3B EIF3I FAF1 GARS1 GHR GRN GTF3C3 HDAC6 HGS HIF1A HSPA1B HSPA4 HSPA4L HSPA8 HSPA9 HSPH1 HYPK KLHDC2 N4BP1 NAE1 NSFL1C NUB1 NXPH2 OLFML2B OTUB1 OTUB2 OTUD5 OTUD6B PARP1 PCNA POLI PPP1CA PRKN PSMA6 PSMD4 PTK2 RAD23A SENP8 SET SIRT1 SMURF1 SQSTM1 TOLLIP TP53 TUBB4B UBA2 UBA3 UBE2K UBE2M UBL7 UBQLN1 UBXN7 UCHL1 UCHL3 YAF2	8 interacting genes: AZI2 CDK6 ITCH LITAF LSM1 MID1 NEDD8 UBC
Entrez ID		4738	9683
HPRD ID		04412
Ensembl ID		ENSG00000129559	ENSG00000102921
Uniprot IDs		Q15843	O75113
PDB IDs		1NDD 1R4M 1R4N 1XT9 2BKR 2KO3 2N7K 2NVU 3DBH 3DBL 3DBR 3DQV 3GZN 4F8C 4FBJ 4HCP 4P5O 6R7F 6R7I 6TTU 7B5L 7B5N 7ONI 8B3G 8B3I 8CAF 8H38 8Q7H 8RX0 8WQC 8WQG 8WZN 8WZO	6Q3V
Enriched GO Terms of Interacting Partners?		Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Protein Catabolic Process Protein Metabolic Process Macromolecule Catabolic Process Proteolysis Involved In Protein Catabolic Process Post-translational Protein Modification Ubiquitin Protein Ligase Binding Proteasomal Protein Catabolic Process Ubiquitin Binding Macromolecule Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Protein Modification Process Protein Modification By Small Protein Conjugation Cytosol Positive Regulation Of Catabolic Process Protein Modification By Small Protein Removal Regulation Of Protein Metabolic Process Nucleoplasm Regulation Of Post-translational Protein Modification Regulation Of Proteolysis Protein Ubiquitination Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Deubiquitination Regulation Of Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Modification Process Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Nucleus Protein Polyubiquitination Protein Targeting To Vacuole Involved In Autophagy Cullin-RING Ubiquitin Ligase Complex DeNEDDylase Activity Aggresome ATP-dependent Protein Folding Chaperone Polyubiquitin Modification-dependent Protein Binding Regulation Of Proteasomal Protein Catabolic Process Protein Folding Response To Stress Protein Neddylation Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Stability Positive Regulation Of Metabolic Process Cellular Response To Stress Cytoplasm	Regulation Of Hematopoietic Stem Cell Differentiation Protein Tag Activity Regulation Of Hematopoietic Progenitor Cell Differentiation T Cell Activation Ubiquitin Protein Ligase Binding Endosome Membrane Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Stem Cell Differentiation Response To Virus Cytoplasm Cyclin D3-CDK6 Complex Lymphocyte Activation Cyclin D1-CDK6 Complex Cyclin D2-CDK6 Complex FBXO Family Protein Binding Macromolecule Catabolic Process Cytoplasmic Side Of Late Endosome Membrane Negative Regulation Of Canonical NF-kappaB Signal Transduction Gliogenesis Negative Regulation Of Monocyte Differentiation Leukocyte Activation Cell Dedifferentiation Cell Activation Response To External Biotic Stimulus Cellular Response To Camptothecin Protein Ubiquitination Modification-dependent Protein Catabolic Process Cytoplasmic Side Of Early Endosome Membrane Lsm1-7-Pat1 Complex Dendritic Cell Proliferation Leukocyte Proliferation Mononuclear Cell Proliferation Positive Regulation Of T Cell Anergy CXCL12-activated CXCR4 Signaling Pathway T Cell Tolerance Induction T Cell Anergy Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation C-X-C Chemokine Receptor CXCR4 Signaling Pathway Early Endosome Membrane Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway Regulation Of T Cell Anergy Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Receptor Catabolic Process CD4-positive, Alpha-beta T Cell Proliferation Arrestin Family Protein Binding Positive Regulation Of T Cell Tolerance Induction Lateral Ventricle Development Type B Pancreatic Cell Development Post-translational Protein Modification
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