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NEDD8 and PARP1
Number of citations of the paper that reports this interaction (PubMedID
16620772
)
0
Data Source:
HPRD
(in vivo)
NEDD8
PARP1
Description
NEDD8 ubiquitin like modifier
poly(ADP-ribose) polymerase 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Extracellular Exosome
Postsynapse
Glutamatergic Synapse
Chromosome, Telomeric Region
Chromatin
Nucleus
Nuclear Envelope
Nucleoplasm
Transcription Regulator Complex
Chromosome
Nucleolus
Cytoplasm
Mitochondrion
Cytosol
Membrane
Nuclear Body
Protein-containing Complex
Protein-DNA Complex
Site Of Double-strand Break
Nuclear Replication Fork
Site Of DNA Damage
Molecular Function
Protein Binding
Protein Tag Activity
Ubiquitin Protein Ligase Binding
DNA Binding
Chromatin Binding
Damaged DNA Binding
RNA Binding
Catalytic Activity
NAD+ Poly-ADP-ribosyltransferase Activity
Protein Binding
Enzyme Activator Activity
Zinc Ion Binding
Transferase Activity
Glycosyltransferase Activity
Nucleotidyltransferase Activity
Enzyme Binding
Protein Kinase Binding
Nuclear Estrogen Receptor Binding
Nucleosome Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Protein Homodimerization Activity
Histone Deacetylase Binding
Metal Ion Binding
NAD Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
R-SMAD Binding
NAD DNA ADP-ribosyltransferase Activity
Transcription Regulator Activator Activity
NAD+-protein-serine ADP-ribosyltransferase Activity
NAD+-protein-aspartate ADP-ribosyltransferase Activity
NAD+-protein-glutamate ADP-ribosyltransferase Activity
NAD+-protein-tyrosine ADP-ribosyltransferase Activity
NAD+-protein-histidine ADP-ribosyltransferase Activity
NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity
NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity
NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity
NAD+-protein Mono-ADP-ribosyltransferase Activity
Biological Process
Regulation Of Transcription By RNA Polymerase II
Proteolysis
Ubiquitin-dependent Protein Catabolic Process
Intracellular Protein Localization
Anatomical Structure Morphogenesis
Protein Ubiquitination
Modification-dependent Protein Catabolic Process
Regulation Of Proteolysis
Protein Modification Process
Protein Neddylation
Cellular Response To Camptothecin
Regulation Of Postsynapse Assembly
Negative Regulation Of Transcription By RNA Polymerase II
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
Immune System Process
DNA Repair
Double-strand Break Repair
Transcription By RNA Polymerase II
Apoptotic Process
DNA Damage Response
Mitochondrion Organization
Transforming Growth Factor Beta Receptor Signaling Pathway
Response To Gamma Radiation
Positive Regulation Of Cardiac Muscle Hypertrophy
Carbohydrate Biosynthetic Process
Protein Autoprocessing
Signal Transduction Involved In Regulation Of Gene Expression
Macrophage Differentiation
DNA ADP-ribosylation
Mitochondrial DNA Metabolic Process
Positive Regulation Of DNA-templated Transcription, Elongation
Cellular Response To Insulin Stimulus
Regulation Of Protein Localization
Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Negative Regulation Of Transcription Elongation By RNA Polymerase II
Cellular Response To Oxidative Stress
Cellular Response To UV
Protein Modification Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Mitochondrial DNA Repair
Innate Immune Response
Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep
Negative Regulation Of Innate Immune Response
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Decidualization
Positive Regulation Of Mitochondrial Depolarization
Positive Regulation Of SMAD Protein Signal Transduction
Positive Regulation Of Necroptotic Process
Protein Poly-ADP-ribosylation
Protein Auto-ADP-ribosylation
Protein Localization To Chromatin
Cellular Response To Zinc Ion
Cellular Response To Transforming Growth Factor Beta Stimulus
Replication Fork Reversal
DNA Repair-dependent Chromatin Remodeling
Negative Regulation Of CGAS/STING Signaling Pathway
Transcription Pausing By RNA Polymerase II
Positive Regulation Of Protein Localization To Nucleus
Cellular Response To Oxygen-containing Compound
Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Response To Aldosterone
Negative Regulation Of Adipose Tissue Development
Positive Regulation Of Adipose Tissue Development
Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
Cellular Response To Amyloid-beta
Positive Regulation Of Myofibroblast Differentiation
Regulation Of Base-excision Repair
Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Cellular Response To Nerve Growth Factor Stimulus
Protein Localization To Site Of Double-strand Break
ATP Generation From Poly-ADP-D-ribose
Negative Regulation Of ATP Biosynthetic Process
Pathways
TGF-beta receptor signaling activates SMADs
UCH proteinases
Cargo recognition for clathrin-mediated endocytosis
Neddylation
Iron uptake and transport
POLB-Dependent Long Patch Base Excision Repair
vRNA Synthesis
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SUMOylation of DNA damage response and repair proteins
HDR through MMEJ (alt-NHEJ)
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
Drugs
Theophylline
Zinc
Carba-nicotinamide-adenine-dinucleotide
NU1025
Nicotinamide
2-{3-[4-(4-Fluorophenyl)-3,6-Dihydro-1(2h)-Pyridinyl]Propyl}-8-Methyl-4(3h)-Quinazolinone
3-Methoxybenzamide
2-(4-Chlorophenyl)-5-Quinoxalinecarboxamide
3,4-Dihydro-5-Methyl-Isoquinolinone
2-(3'-Methoxyphenyl) Benzimidazole-4-Carboxamide
6-AMINO-BENZO[DE]ISOQUINOLINE-1,3-DIONE
Veliparib
A-620223
5-FLUORO-1-[4-(4-PHENYL-3,6-DIHYDROPYRIDIN-1(2H)-YL)BUTYL]QUINAZOLINE-2,4(1H,3H)-DIONE
Olaparib
Talazoparib
Niraparib
Rucaparib
Iniparib
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
GWAS
Mean corpuscular volume (
29403010
)
Systolic blood pressure (cigarette smoking interaction) (
26752167
)
Coronary artery disease (
29212778
)
Leukocyte telomere length (
31171785
32109421
)
Melanoma (
21983785
)
Mild to moderate chronic kidney disease (
31178898
)
Nevus count or cutaneous melanoma (
30429480
32341527
)
Platelet count (
29403010
)
Telomere length (
29151059
)
Interacting Genes
71 interacting genes:
AHR
ANKRD13D
ARIH2
ATXN3
BAG3
CBLB
CDC34
COPS5
COPS6
CTRC
CUL1
CUL2
CUL3
CUL4B
DNAJA2
DNAJB2
DNMT3B
EIF3I
FAF1
GARS1
GHR
GRN
GTF3C3
HDAC6
HGS
HIF1A
HSPA1B
HSPA4
HSPA4L
HSPA8
HSPA9
HSPH1
HYPK
KLHDC2
N4BP1
NAE1
NSFL1C
NUB1
NXPH2
OLFML2B
OTUB1
OTUB2
OTUD5
OTUD6B
PARP1
PCNA
POLI
PPP1CA
PRKN
PSMA6
PSMD4
PTK2
RAD23A
SENP8
SET
SIRT1
SMURF1
SQSTM1
TOLLIP
TP53
TUBB4B
UBA2
UBA3
UBE2K
UBE2M
UBL7
UBQLN1
UBXN7
UCHL1
UCHL3
YAF2
123 interacting genes:
AATF
ANXA1
APTX
ATM
ATR
BCL2
BGLT3
BLID
BRD7
BUB3
CASP1
CASP3
CASP7
CASP8
CD86
CDKN1A
CEBPA
CENPA
CENPB
CTCF
CTSB
CTSG
DTX2
DUX4
E2F1
E4F1
EPB41L2
ERBB2
ERCC6
ERG
ETS1
FNDC3B
FOXO1
GTF2F1
GZMB
GZMM
H1-1
H1-2
H1-5
H2AC18
H2BC4
H3-4
H4C3
HDAC1
HDAC3
HECTD3
HIPK2
HMGN1
HMGN2
HMGN4
HOXB7
HPF1
HSPA2
IKBKG
IL24
KAT2B
KLF5
LIG3
LINC00624
LZTR1
MACROH2A1
MALAT1
MED14
MED6
MORC2
MTA3
MYBL2
NAT10
NCL
NCOA6
NEDD8
NFATC1
NFKB1
NPM1
NRF1
NUDT16
OGT
OVOL2
PARP2
PARP3
PCNA
PIAS4
POLA1
POLA2
POU2F1
PRKDC
RARA
RASL10B
RBM14
RELA
RNF10
RNF144A
RNF168
RNF4
RPS3A
RSPH1
RXRA
SENP1
SENP3
SMURF2
SP1
SREK1
SUMO2
SUPT16H
SWAP70
TCF3
TCF4
THRSP
TP53
TP53BP1
TRIP12
UBE2I
USP1
USP15
USP7
WEE2-AS1
WRN
XRCC1
XRCC5
XRCC6
ZBTB16
ZBTB9
ZNF423
Entrez ID
4738
142
HPRD ID
04412
01435
Ensembl ID
ENSG00000129559
ENSG00000143799
Uniprot IDs
Q15843
P09874
PDB IDs
1NDD
1R4M
1R4N
1XT9
2BKR
2KO3
2N7K
2NVU
3DBH
3DBL
3DBR
3DQV
3GZN
4F8C
4FBJ
4HCP
4P5O
6R7F
6R7I
6TTU
7B5L
7B5N
7ONI
8B3G
8B3I
8CAF
8H38
8Q7H
8RX0
8WQC
8WQG
8WZN
8WZO
1UK0
1UK1
1WOK
2COK
2CR9
2CS2
2DMJ
2JVN
2L30
2L31
2N8A
2RCW
2RD6
2RIQ
3GJW
3GN7
3L3L
3L3M
3OD8
3ODA
3ODC
3ODE
4AV1
4DQY
4GV7
4HHY
4HHZ
4L6S
4OPX
4OQA
4OQB
4PJT
4R5W
4R6E
4RV6
4UND
4UXB
4XHU
4ZZZ
5A00
5DS3
5HA9
5KPN
5KPO
5KPP
5KPQ
5WRQ
5WRY
5WRZ
5WS0
5WS1
5WTC
5XSR
5XST
5XSU
6BHV
6GHK
6M3I
6NRF
6NRG
6NRH
6NRI
6NRJ
6NTU
6VKK
6VKO
6VKQ
6XVW
7AAA
7AAB
7AAC
7AAD
7CMW
7KK2
7KK3
7KK4
7KK5
7KK6
7ONR
7ONS
7ONT
7S68
7S6H
7S6M
7S81
7SCY
7SCZ
8FYY
8FYZ
8FZ1
8G0H
8HE7
8HLR
8JNZ
8U4W
9BPY
9CKC
9DMC
9ETQ
9ETR
Enriched GO Terms of Interacting Partners
?
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis
Protein Catabolic Process
Protein Metabolic Process
Macromolecule Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Post-translational Protein Modification
Ubiquitin Protein Ligase Binding
Proteasomal Protein Catabolic Process
Ubiquitin Binding
Macromolecule Metabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Catabolic Process
Protein Modification Process
Protein Modification By Small Protein Conjugation
Cytosol
Positive Regulation Of Catabolic Process
Protein Modification By Small Protein Removal
Regulation Of Protein Metabolic Process
Nucleoplasm
Regulation Of Post-translational Protein Modification
Regulation Of Proteolysis
Protein Ubiquitination
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Protein Deubiquitination
Regulation Of Protein Catabolic Process
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Modification Process
Positive Regulation Of Proteolysis
Positive Regulation Of Protein Catabolic Process
Nucleus
Protein Polyubiquitination
Protein Targeting To Vacuole Involved In Autophagy
Cullin-RING Ubiquitin Ligase Complex
DeNEDDylase Activity
Aggresome
ATP-dependent Protein Folding Chaperone
Polyubiquitin Modification-dependent Protein Binding
Regulation Of Proteasomal Protein Catabolic Process
Protein Folding
Response To Stress
Protein Neddylation
Positive Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Protein Stability
Positive Regulation Of Metabolic Process
Cellular Response To Stress
Cytoplasm
Nucleoplasm
Nucleus
DNA Binding
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Metabolic Process
Regulation Of Primary Metabolic Process
Chromatin Organization
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
DNA Damage Response
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Chromatin Binding
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of Metabolic Process
Chromatin Remodeling
Regulation Of Gene Expression
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of Metabolic Process
Macromolecule Metabolic Process
Chromosome
Protein Modification Process
Negative Regulation Of DNA Metabolic Process
DNA Repair
DNA Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Cell Cycle
Chromatin
Cellular Response To Stress
Post-translational Protein Modification
Negative Regulation Of Biosynthetic Process
Transcription Cis-regulatory Region Binding
Regulation Of DNA Metabolic Process
Double-strand Break Repair Via Nonhomologous End Joining
Double-strand Break Repair
Negative Regulation Of Cell Cycle
Protein Localization To Chromosome
Negative Regulation Of RNA Metabolic Process
Regulation Of Cell Cycle Process
Transcription Regulator Complex
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Tagcloud (Intersection)
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