NEDD8 and HSPA4L

Number of citations of the paper that reports this interaction (PubMedID 34642328)
74

Data Source:
BioGRID (pull down)

		NEDD8	HSPA4L
Description		NEDD8 ubiquitin like modifier	heat shock protein family A (Hsp70) member 4 like
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Exosome Postsynapse Glutamatergic Synapse	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding Protein Tag Activity Ubiquitin Protein Ligase Binding	Nucleotide Binding Adenyl-nucleotide Exchange Factor Activity ATP Binding ATP-dependent Protein Folding Chaperone
	Biological Process	Regulation Of Transcription By RNA Polymerase II Proteolysis Ubiquitin-dependent Protein Catabolic Process Intracellular Protein Localization Anatomical Structure Morphogenesis Protein Ubiquitination Modification-dependent Protein Catabolic Process Regulation Of Proteolysis Protein Modification Process Protein Neddylation Cellular Response To Camptothecin Regulation Of Postsynapse Assembly	Protein Folding Response To Unfolded Protein
Pathways		TGF-beta receptor signaling activates SMADs UCH proteinases Cargo recognition for clathrin-mediated endocytosis Neddylation Iron uptake and transport	Regulation of HSF1-mediated heat shock response
Drugs
Diseases
GWAS		Mean corpuscular volume ( 29403010) Systolic blood pressure (cigarette smoking interaction) ( 26752167)	High light scatter reticulocyte percentage of red cells ( 32888494) Major depressive disorder ( 29317602)
Interacting Genes		71 interacting genes: AHR ANKRD13D ARIH2 ATXN3 BAG3 CBLB CDC34 COPS5 COPS6 CTRC CUL1 CUL2 CUL3 CUL4B DNAJA2 DNAJB2 DNMT3B EIF3I FAF1 GARS1 GHR GRN GTF3C3 HDAC6 HGS HIF1A HSPA1B HSPA4 HSPA4L HSPA8 HSPA9 HSPH1 HYPK KLHDC2 N4BP1 NAE1 NSFL1C NUB1 NXPH2 OLFML2B OTUB1 OTUB2 OTUD5 OTUD6B PARP1 PCNA POLI PPP1CA PRKN PSMA6 PSMD4 PTK2 RAD23A SENP8 SET SIRT1 SMURF1 SQSTM1 TOLLIP TP53 TUBB4B UBA2 UBA3 UBE2K UBE2M UBL7 UBQLN1 UBXN7 UCHL1 UCHL3 YAF2	5 interacting genes: MSRA NEDD8 PAXIP1 PHLDA1 PTEN
Entrez ID		4738	22824
HPRD ID		04412	07137
Ensembl ID		ENSG00000129559	ENSG00000164070
Uniprot IDs		Q15843	A0A140VKE7 B4DXT2 B4DZR0 E9PDE8 O95757
PDB IDs		1NDD 1R4M 1R4N 1XT9 2BKR 2KO3 2N7K 2NVU 3DBH 3DBL 3DBR 3DQV 3GZN 4F8C 4FBJ 4HCP 4P5O 6R7F 6R7I 6TTU 7B5L 7B5N 7ONI 8B3G 8B3I 8CAF 8H38 8Q7H 8RX0 8WQC 8WQG 8WZN 8WZO
Enriched GO Terms of Interacting Partners?		Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Protein Catabolic Process Protein Metabolic Process Macromolecule Catabolic Process Proteolysis Involved In Protein Catabolic Process Post-translational Protein Modification Ubiquitin Protein Ligase Binding Proteasomal Protein Catabolic Process Ubiquitin Binding Macromolecule Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Protein Modification Process Protein Modification By Small Protein Conjugation Cytosol Positive Regulation Of Catabolic Process Protein Modification By Small Protein Removal Regulation Of Protein Metabolic Process Nucleoplasm Regulation Of Post-translational Protein Modification Regulation Of Proteolysis Protein Ubiquitination Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Deubiquitination Regulation Of Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Modification Process Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Nucleus Protein Polyubiquitination Protein Targeting To Vacuole Involved In Autophagy Cullin-RING Ubiquitin Ligase Complex DeNEDDylase Activity Aggresome ATP-dependent Protein Folding Chaperone Polyubiquitin Modification-dependent Protein Binding Regulation Of Proteasomal Protein Catabolic Process Protein Folding Response To Stress Protein Neddylation Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Stability Positive Regulation Of Metabolic Process Cellular Response To Stress Cytoplasm	Nucleoplasm L-methionine:thioredoxin-disulfide S-oxidoreductase Activity Peptide-methionine (S)-S-oxide Reductase Activity L-methionine-(S)-S-oxide Reductase Activity Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Chorion Development Cellular Response To Camptothecin Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Phosphatidylinositol Phosphate Phosphatase Activity Protein Repair Regulation Of Cell Junction Assembly Locomotor Rhythm Cellular Response To Electrical Stimulus Ubiquitin Ligase Activator Activity Spindle Assembly Involved In Female Meiosis Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Synaptic Vesicle Clustering Postsynaptic Specialization Assembly Neuron-neuron Synaptic Transmission Negative Regulation Of Cell Size Presynaptic Membrane Organization Schmidt-Lanterman Incisure Anaphase-promoting Complex Binding Postsynaptic Density Assembly Forebrain Morphogenesis Negative Regulation Of Excitatory Postsynaptic Potential Presynaptic Membrane Assembly MLL3/4 Complex Positive Regulation Of Isotype Switching To IgG Isotypes Methionine Metabolic Process Regulation Of Proteolysis Protein Tag Activity Phosphatidylinositol-3-phosphate Phosphatase Activity Prepulse Inhibition Meiotic Spindle Assembly Synapse Maturation Maternal Behavior Myelin Maintenance Negative Regulation Of Epithelial Cell Migration Parental Behavior Regulation Of Isotype Switching To IgG Isotypes Dendritic Spine Morphogenesis
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