LPL and VLDLR

Number of citations of the paper that reports this interaction (PubMedID 7592875)
0

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		LPL	VLDLR
Description		lipoprotein lipase	very low density lipoprotein receptor
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Membrane Very-low-density Lipoprotein Particle Chylomicron Catalytic Complex	Extracellular Space Lysosomal Membrane Plasma Membrane Clathrin-coated Pit Membrane Very-low-density Lipoprotein Particle Receptor Complex Synapse Glutamatergic Synapse
	Molecular Function	Lipoprotein Lipase Activity Phospholipase Activity Triacylglycerol Lipase Activity Signaling Receptor Binding Calcium Ion Binding Protein Binding Heparin Binding Phospholipase A1 Activity Lipase Activity Hydrolase Activity Apolipoprotein Binding Protein Homodimerization Activity Heparan Sulfate Proteoglycan Binding Protein-membrane Adaptor Activity Metal Ion Binding Carboxylic Ester Hydrolase Activity Lipoprotein Particle Binding	Low-density Lipoprotein Particle Receptor Activity Calcium Ion Binding Protein Binding Very-low-density Lipoprotein Particle Receptor Activity Apolipoprotein Binding Very-low-density Lipoprotein Particle Binding Cargo Receptor Activity Reelin Receptor Activity Calcium-dependent Protein Binding
	Biological Process	Retinoid Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Triglyceride Metabolic Process Phospholipid Metabolic Process Response To Bacterium Response To Glucose Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Positive Regulation Of Cholesterol Storage Lipid Catabolic Process Triglyceride Catabolic Process Cellular Response To Nutrient Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Chylomicron Remodeling Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Very-low-density Lipoprotein Particle Clearance Cholesterol Homeostasis Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Inflammatory Response Low-density Lipoprotein Particle Mediated Signaling Triglyceride Homeostasis Cellular Response To Fatty Acid Positive Regulation Of Adipose Tissue Development Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production	Lipid Metabolic Process Lipid Transport Endocytosis Receptor-mediated Endocytosis Signal Transduction Nervous System Development Memory Steroid Metabolic Process Cholesterol Metabolic Process Ventral Spinal Cord Development Glycoprotein Transport Very-low-density Lipoprotein Particle Clearance Reelin-mediated Signaling Pathway Dendrite Morphogenesis Regulation Of Synapse Assembly Positive Regulation Of Dendrite Development
Pathways		Transcriptional regulation of white adipocyte differentiation Assembly of active LPL and LIPC lipase complexes Chylomicron remodeling Retinoid metabolism and transport MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Reelin signalling pathway VLDLR internalisation and degradation VLDL clearance
Drugs		Tyloxapol Omega-3-carboxylic acids Glycyrrhizic acid	Lauric acid
Diseases		Hyperlipoproteinemia, type I
GWAS		Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Body mass index (adult) ( 28430825) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Cardiovascular disease risk factors ( 21943158) Cholesterol ( 31902109) Cholesterol efflux capacity ( 30369316) Coronary artery disease ( 24262325 29212778 32469254 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diffusing capacity of carbon monoxide ( 30694715) Eosinophil count ( 32888494) Fasting triglyceride levels ( 32603185) Gut microbiota (beta diversity) ( 27723756) HDL cholesterol ( 18193043 18193044 19060906 19060911 20031538 20686565 20864672 21347282 21909109 23726366 24097068 24507774 25961943 26160806 26582766 26780889 28270201) HDL Cholesterol - Triglycerides (HDLC-TG) ( 21386085) HDL cholesterol levels ( 26763881 28334899 30698716 31694877 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) HDL levels x fish oil supplementation interaction (2df) ( 33760818) Hematological and biochemical traits ( 20139978) High density lipoprotein cholesterol levels ( 28548082 29403010 29615537 30718733 30911093 32902719 33339817) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hyperactive-impulsive symptoms ( 18821565) Hypertriglyceridemia ( 20657596 23505323) Lipid metabolism phenotypes ( 19936222 22286219) Lipid traits ( 24023261 24386095) Lipoprotein (a) levels ( 33730874) Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643) Low density lipoprotein cholesterol levels ( 32154731 32902719) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (antithrombotic agents) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 20694148 21386085 22399527 30382898 31589552) Metabolic syndrome (bivariate traits) ( 21386085) Metabolic syndrome (multivariate analysis) ( 29632305) Metabolic traits ( 19060910) Metabolically unhealthy in normal weight ( 33500527) Metabolically unhealthy in obesity ( 33500527) Metabolite levels ( 22916037) Myocardial infarction ( 33532862) Non-HDL cholesterol levels ( 32902719) Nonalcoholic fatty liver disease ( 34841290) Peripheral artery disease ( 31285632) Persistent hepatitis B virus infection ( 27244555) Platelet distribution width ( 32888494) Postprandial triglyceride levels ( 32603185) Pulse pressure ( 27841878) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Systolic blood pressure ( 27841878) Total cholesterol levels ( 32902719) Total triglycerides levels ( 26690388 29084231) Triacylglyceride levels ( 31551469) Triglyceride levels ( 26763881 28334899 29403010 29615537 30698716 30718733 30911093 32154731 32203549 33339817) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels in HIV infection ( 33109212) Triglyceride levels in small VLDL ( 29084231) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglyceride to HDL cholesterol ratio ( 28046027) Triglycerides ( 17463246 18193043 18193044 18193046 19060906 19060911 20139978 20686565 20864672 21909109 22171074 23726366 24097068 24507774 24886709 25961943 26160806 26582766) Triglycerides-Blood Pressure (TG-BP) ( 21386085) Type 2 diabetes ( 29632382 30054458 30297969) Type 2 diabetes (adjusted for BMI) ( 29632382) Waist circumference and related phenotypes ( 18454146)	Alzheimer's disease (age of onset) ( 22005931) Apolipoprotein B levels ( 32203549) Cholesterol, total ( 24097068) Cytokine levels ( 31679650) Cytokine network levels (multivariate analysis) ( 31679650) Gambling ( 22780124) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Inflammatory biomarkers (multivariate analysis) ( 33110245) LDL cholesterol ( 30275531 24097068) LDL cholesterol levels ( 28334899 32203549) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 32888494) Systolic blood pressure ( 26969751) Total cholesterol levels ( 30275531) Vascular endothelial growth factor levels ( 21757650 31217265 27989323 26910538) White blood cell count ( 32888494) White coat effect (clinic diastolic blood pressure minus ambulatory diastolic blood pressure) ( 31044621)
Interacting Genes		18 interacting genes: APOC2 APP ASCC2 CALR CCND1 CEP126 CETP COPS6 EMD LRP1 LRP2 LUC7L2 NEIL3 PTPN4 RPL18A TSC22D2 UBE2Z VLDLR	12 interacting genes: APOE CD36 CLU DAB1 DYRK1A ITSN1 LPL LRPAP1 MYLIP RELN SNX17 ZSCAN12
Entrez ID		4023	7436
HPRD ID		01999	01895
Ensembl ID		ENSG00000175445	ENSG00000147852
Uniprot IDs		A0A1B1RVA9 P06858	A0A7P0T897 A0A7P0T8N9 A0A7P0T9P7 P98155 Q5VVF5
PDB IDs		6E7K 6OAU 6OAZ 6OB0 6WN4	1V9U 3DPR 6BYV 8IHP 8UA4 8UA8 8UFB 8UFC 8X0K 8X0L 8X0M 8XI4 8XI5 8YS2 8YS4 8YVZ 8YW0 8YW1 8YW2
Enriched GO Terms of Interacting Partners?		Apolipoprotein Binding Clathrin-coated Pit Low-density Lipoprotein Particle Receptor Activity Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Cargo Receptor Activity Astrocyte Activation Involved In Immune Response Intermediate-density Lipoprotein Particle Positive Regulation Of Lysosomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process In The Vacuole Very-low-density Lipoprotein Particle Remodeling Triglyceride-rich Lipoprotein Particle Remodeling Regulation Of Cholesterol Transport Receptor Complex Regulation Of Lysosomal Protein Catabolic Process Low-density Lipoprotein Particle Hormone Binding Reverse Cholesterol Transport Protein-folding Chaperone Binding Heparan Sulfate Proteoglycan Binding Astrocyte Activation Response To Leptin Transcytosis Regulation Of Amyloid-beta Clearance Endosome Lumen Regulation Of Endocytosis Molecular Function Activator Activity Amyloid-beta Clearance Plasma Lipoprotein Particle Clearance Regulation Of Lipid Transport Amyloid Fibril Formation Lipoprotein Metabolic Process Plasma Lipoprotein Particle Remodeling Positive Regulation Of Endocytosis Positive Regulation Of Cholesterol Transport Protein-containing Complex Remodeling Negative Regulation Of Wnt Signaling Pathway Receptor-mediated Endocytosis Triglyceride Homeostasis Acylglycerol Homeostasis Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Endocytosis Regulation Of Cholesterol Efflux TMEM240-body Positive Regulation Of Transcytosis Alpha-2 Macroglobulin Receptor Activity	Very-low-density Lipoprotein Particle Receptor Binding Low-density Lipoprotein Particle Receptor Binding Regulation Of Neurofibrillary Tangle Assembly Lipoprotein Particle Binding Receptor Ligand Activity Regulation Of Endocytosis Regulation Of Inclusion Body Assembly Amyloid-beta Binding Regulation Of Amyloid-beta Clearance Positive Regulation Of Neurofibrillary Tangle Assembly Regulation Of Cellular Component Organization Amyloid-beta Clearance Plasma Lipoprotein Particle Clearance Regulation Of Vesicle-mediated Transport Lateral Motor Column Neuron Migration Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Dendritic Spine Development Low-density Lipoprotein Particle Mediated Signaling Spinal Cord Motor Neuron Migration Positive Regulation Of Nitric Oxide Metabolic Process Tau Protein Binding Very-low-density Lipoprotein Particle Clearance Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Endocytosis NMDA Glutamate Receptor Clustering Positive Regulation Of Inclusion Body Assembly Regulation Of Amyloid-beta Formation Negative Regulation Of Cellular Component Organization Regulation Of Amyloid Precursor Protein Catabolic Process Signaling Receptor Binding Regulation Of Dendritic Spine Development Receptor-mediated Endocytosis Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Protein Import Positive Regulation Of Cholesterol Storage Regulation Of Nitric Oxide Biosynthetic Process Very-low-density Lipoprotein Particle Remodeling Positive Regulation Of Amyloid-beta Clearance Cholesterol Catabolic Process Regulation Of Nitric Oxide Metabolic Process Ventral Spinal Cord Development Cholesterol Transport Nitric Oxide-cGMP-mediated Signaling Triglyceride-rich Lipoprotein Particle Remodeling Sterol Transport Regulation Of Amide Metabolic Process Reelin-mediated Signaling Pathway Neurotransmitter-gated Ion Channel Clustering Cholesterol Homeostasis Chylomicron
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