LPL and CETP

Number of citations of the paper that reports this interaction (PMID 9374130)
1

Data Source:
HPRD (in vivo)

		LPL	CETP
Gene Name		lipoprotein lipase	cholesteryl ester transfer protein, plasma
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Extracellular Matrix Anchored Component Of Membrane Very-low-density Lipoprotein Particle Chylomicron Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Vesicle High-density Lipoprotein Particle Extracellular Vesicular Exosome
	Molecular Function	Lipoprotein Lipase Activity Phospholipase Activity Triglyceride Lipase Activity Receptor Binding Protein Binding Heparin Binding Triglyceride Binding Apolipoprotein Binding	Lipid Transporter Activity Phospholipid Transporter Activity Lipid Binding Cholesterol Binding Cholesterol Transporter Activity Triglyceride Binding Phosphatidylcholine Binding
	Biological Process	Retinoid Metabolic Process Fatty Acid Biosynthetic Process Triglyceride Metabolic Process Phospholipid Metabolic Process Phototransduction, Visible Light Response To Cold Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Storage Positive Regulation Of Sequestering Of Triglyceride Triglyceride Biosynthetic Process Triglyceride Catabolic Process Chylomicron Remodeling Very-low-density Lipoprotein Particle Remodeling Lipoprotein Metabolic Process Response To Drug Small Molecule Metabolic Process Triglyceride Homeostasis	Triglyceride Metabolic Process Lipid Transport Receptor-mediated Endocytosis Cholesterol Metabolic Process Negative Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Cholesterol Efflux Phospholipid Transport Cholesterol Transport Triglyceride Transport Very-low-density Lipoprotein Particle Remodeling Low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Lipoprotein Metabolic Process Cholesterol Homeostasis Reverse Cholesterol Transport Small Molecule Metabolic Process Phosphatidylcholine Metabolic Process Transmembrane Transport Lipid Homeostasis Phospholipid Homeostasis Triglyceride Homeostasis
Pathways		Lipoprotein metabolism Visual phototransduction Metabolism of lipids and lipoproteins Chylomicron-mediated lipid transport Transcriptional regulation of white adipocyte differentiation Lipid digestion, mobilization, and transport Diseases associated with visual transduction Retinoid metabolism and transport	Lipoprotein metabolism HDL-mediated lipid transport LDL-mediated lipid transport Metabolism of lipids and lipoproteins Lipid digestion, mobilization, and transport Orphan transporters
Drugs		Tyloxapol
Diseases
GWAS		Cardiovascular disease risk factors ( 21943158) HDL cholesterol ( 23726366 20031538 21909109 18193043 18193044 20864672 19060906 19060911 20686565) HDL Cholesterol - Triglycerides (HDLC-TG) ( 21386085) Hematological and biochemical traits ( 20139978) Hyperactive-impulsive symptoms ( 18821565) Hypertriglyceridemia ( 23505323 20657596) Lipid metabolism phenotypes ( 22286219 19936222) Metabolic syndrome ( 22399527 21386085 20694148) Metabolic syndrome (bivariate traits) ( 21386085) Metabolic traits ( 19060910) Metabolite levels ( 22916037) Triglycerides ( 23726366 21909109 18193043 18193044 18193046 20864672 19060906 19060911 22171074 20139978 17463246 20686565) Triglycerides-Blood Pressure (TG-BP) ( 21386085) Waist circumference and related phenotypes ( 18454146)	Age-related macular degeneration ( 20385819 23455636 21665990) Biochemical measures ( 19260141) Cardiovascular disease risk factors ( 21943158 20838585) Cholesterol ( 20066028) Cholesterol, total ( 20686565) Coronary heart disease ( 21347282) HDL cholesterol ( 23726366 20031538 19359809 20031564 21909109 18193043 18193044 20864672 19060906 23505323 19060910 19060911 20686565) HDL Cholesterol - Triglycerides (HDLC-TG) ( 21386085) Hematological and biochemical traits ( 20139978) LDL cholesterol ( 20686565) Lipid metabolism phenotypes ( 22286219 19936222) Lipoprotein-associated phospholipase A2 activity and mass ( 22003152 23118302) Metabolic syndrome ( 22399527 21386085 20694148) Metabolic syndrome (bivariate traits) ( 21386085) Metabolite levels ( 22916037) Triglycerides ( 17463246 20686565) Waist circumference and related phenotypes ( 18454146)
Protein-Protein Interactions		16 interactors: APOC2 APP ASCC2 CALR CCND1 CETP COPS6 EMD KIAA1377 LRP1 LRP2 LUC7L2 PTPN4 RPL18A UBE2Z VLDLR	5 interactors: APOA1 ARPC3 EWSR1 LPL PRKACG
Entrez ID		4023	1071
HPRD ID		01999	00325
Ensembl ID		ENSG00000175445	ENSG00000087237
Uniprot IDs		P06858	P11597
PDB IDs			2OBD 4EWS 4F2A
Enriched GO Terms of Interacting Partners?		Steroid Metabolic Process Cholesterol Metabolic Process Sterol Metabolic Process Response To Light Stimulus Regulation Of Cholesterol Transport Alcohol Metabolic Process Receptor-mediated Endocytosis Endocytosis Response To Radiation Regulation Of Plasma Lipoprotein Particle Levels Very-low-density Lipoprotein Particle Remodeling Phototransduction, Visible Light Retinoid Metabolic Process Triglyceride-rich Lipoprotein Particle Remodeling Diterpenoid Metabolic Process Detection Of Visible Light Regulation Of Lipid Transport Phototransduction Detection Of Light Stimulus Reverse Cholesterol Transport Isoprenoid Metabolic Process Regulation Of Cholesterol Efflux Lipid Metabolic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Metabolic Process Plasma Lipoprotein Particle Remodeling Lipoprotein Metabolic Process Detection Of Abiotic Stimulus Vesicle-mediated Transport Triglyceride Homeostasis Plasma Lipoprotein Particle Clearance Acylglycerol Homeostasis Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Response To Abiotic Stimulus Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Peptide Antigen Assembly With MHC Class I Protein Complex Beta-amyloid Clearance Positive Regulation Of Cell Cycle Cholesterol Transport Sterol Transport Lipid Transport Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Differentiation Regulation Of Protein Kinase Activity Lipid Localization Cholesterol Homeostasis Sterol Homeostasis Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling	Triglyceride Catabolic Process Acylglycerol Catabolic Process Plasma Lipoprotein Particle Remodeling Triglyceride Homeostasis Acylglycerol Homeostasis Glycerolipid Metabolic Process Regulation Of Plasma Lipoprotein Particle Levels Phototransduction, Visible Light Retinoid Metabolic Process Diterpenoid Metabolic Process Positive Regulation Of Lipase Activity Detection Of Visible Light Triglyceride Metabolic Process Phototransduction Neutral Lipid Metabolic Process Detection Of Light Stimulus Negative Regulation Of Cell Adhesion Molecule Production Lipid Homeostasis Isoprenoid Metabolic Process Cellular Lipid Catabolic Process Negative Regulation Of Interleukin-1 Beta Secretion Chemical Homeostasis Lipoprotein Metabolic Process Detection Of Abiotic Stimulus Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Cholesterol Import Chylomicron Remodeling Cellular Lipid Metabolic Process Positive Regulation Of Cytoskeleton Organization Negative Regulation Of Interleukin-1 Secretion Lipid Catabolic Process High-density Lipoprotein Particle Clearance Positive Regulation Of Sequestering Of Triglyceride Protein Oxidation Lipid Metabolic Process Negative Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Cytokine Secretion Involved In Immune Response High-density Lipoprotein Particle Assembly Positive Regulation Of Cellular Component Biogenesis Very-low-density Lipoprotein Particle Remodeling Homeostatic Process Positive Regulation Of Triglyceride Catabolic Process Positive Regulation Of Cholesterol Esterification Regulation Of Intestinal Cholesterol Absorption Phospholipid Homeostasis Peptidyl-methionine Modification Response To Light Stimulus Response To Stress Regulation Of Actin Cytoskeleton Organization Regulation Of Cholesterol Esterification
Tagcloud ?		8p21 apolipoprotein assigned atherosclerosis c5 c9 characterizing cli clones clusterin complement consider cosmid cytolytic determining glycoprotein isolating kb lipase lipoprotein nicked overlapping secreted seminal sertoli spans subchromosomal symbol translationally	allele allelic b1 b1b1 b2b2 carriers causal causally chd cholesteryl circulating duplicate embase ester genotype genotypic instrument marginally mendelian mug probabilities publication pubmed qualified randomization rs708272 searched unresolved weighted
Tagcloud (Difference) ?		8p21 apolipoprotein assigned atherosclerosis c5 c9 characterizing cli clones clusterin complement consider cosmid cytolytic determining glycoprotein isolating kb lipase lipoprotein nicked overlapping secreted seminal sertoli spans subchromosomal symbol translationally	allele allelic b1 b1b1 b2b2 carriers causal causally chd cholesteryl circulating duplicate embase ester genotype genotypic instrument marginally mendelian mug probabilities publication pubmed qualified randomization rs708272 searched unresolved weighted
Tagcloud (Intersection) ?