LPL

Description		lipoprotein lipase
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Membrane Very-low-density Lipoprotein Particle Chylomicron Catalytic Complex
	Molecular Function	Lipoprotein Lipase Activity Phospholipase Activity Triacylglycerol Lipase Activity Signaling Receptor Binding Calcium Ion Binding Protein Binding Heparin Binding Phospholipase A1 Activity Lipase Activity Hydrolase Activity Apolipoprotein Binding Protein Homodimerization Activity Heparan Sulfate Proteoglycan Binding Protein-membrane Adaptor Activity Metal Ion Binding Carboxylic Ester Hydrolase Activity Lipoprotein Particle Binding
	Biological Process	Retinoid Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Triglyceride Metabolic Process Phospholipid Metabolic Process Response To Bacterium Response To Glucose Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Positive Regulation Of Cholesterol Storage Lipid Catabolic Process Triglyceride Catabolic Process Cellular Response To Nutrient Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Chylomicron Remodeling Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Very-low-density Lipoprotein Particle Clearance Cholesterol Homeostasis Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Inflammatory Response Low-density Lipoprotein Particle Mediated Signaling Triglyceride Homeostasis Cellular Response To Fatty Acid Positive Regulation Of Adipose Tissue Development Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways		Transcriptional regulation of white adipocyte differentiation Assembly of active LPL and LIPC lipase complexes Chylomicron remodeling Retinoid metabolism and transport MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs		Tyloxapol Omega-3-carboxylic acids Glycyrrhizic acid
Diseases		Hyperlipoproteinemia, type I
GWAS		Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Body mass index (adult) ( 28430825) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Cardiovascular disease risk factors ( 21943158) Cholesterol ( 31902109) Cholesterol efflux capacity ( 30369316) Coronary artery disease ( 24262325 29212778 32469254 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diffusing capacity of carbon monoxide ( 30694715) Eosinophil count ( 32888494) Fasting triglyceride levels ( 32603185) Gut microbiota (beta diversity) ( 27723756) HDL cholesterol ( 18193043 18193044 19060906 19060911 20031538 20686565 20864672 21347282 21909109 23726366 24097068 24507774 25961943 26160806 26582766 26780889 28270201) HDL Cholesterol - Triglycerides (HDLC-TG) ( 21386085) HDL cholesterol levels ( 26763881 28334899 30698716 31694877 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) HDL levels x fish oil supplementation interaction (2df) ( 33760818) Hematological and biochemical traits ( 20139978) High density lipoprotein cholesterol levels ( 28548082 29403010 29615537 30718733 30911093 32902719 33339817) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hyperactive-impulsive symptoms ( 18821565) Hypertriglyceridemia ( 20657596 23505323) Lipid metabolism phenotypes ( 19936222 22286219) Lipid traits ( 24023261 24386095) Lipoprotein (a) levels ( 33730874) Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643) Low density lipoprotein cholesterol levels ( 32154731 32902719) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (antithrombotic agents) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 20694148 21386085 22399527 30382898 31589552) Metabolic syndrome (bivariate traits) ( 21386085) Metabolic syndrome (multivariate analysis) ( 29632305) Metabolic traits ( 19060910) Metabolically unhealthy in normal weight ( 33500527) Metabolically unhealthy in obesity ( 33500527) Metabolite levels ( 22916037) Myocardial infarction ( 33532862) Non-HDL cholesterol levels ( 32902719) Nonalcoholic fatty liver disease ( 34841290) Peripheral artery disease ( 31285632) Persistent hepatitis B virus infection ( 27244555) Platelet distribution width ( 32888494) Postprandial triglyceride levels ( 32603185) Pulse pressure ( 27841878) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Systolic blood pressure ( 27841878) Total cholesterol levels ( 32902719) Total triglycerides levels ( 26690388 29084231) Triacylglyceride levels ( 31551469) Triglyceride levels ( 26763881 28334899 29403010 29615537 30698716 30718733 30911093 32154731 32203549 33339817) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels in HIV infection ( 33109212) Triglyceride levels in small VLDL ( 29084231) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglyceride to HDL cholesterol ratio ( 28046027) Triglycerides ( 17463246 18193043 18193044 18193046 19060906 19060911 20139978 20686565 20864672 21909109 22171074 23726366 24097068 24507774 24886709 25961943 26160806 26582766) Triglycerides-Blood Pressure (TG-BP) ( 21386085) Type 2 diabetes ( 29632382 30054458 30297969) Type 2 diabetes (adjusted for BMI) ( 29632382) Waist circumference and related phenotypes ( 18454146)
Interacting Genes		18 interacting genes: APOC2 APP ASCC2 CALR CCND1 CEP126 CETP COPS6 EMD LRP1 LRP2 LUC7L2 NEIL3 PTPN4 RPL18A TSC22D2 UBE2Z VLDLR
Entrez ID		4023
HPRD ID		01999
Ensembl ID		ENSG00000175445
Uniprot IDs		A0A1B1RVA9 P06858
PDB IDs		6E7K 6OAU 6OAZ 6OB0 6WN4
Enriched GO Terms of Interacting Partners?		Apolipoprotein Binding Clathrin-coated Pit Low-density Lipoprotein Particle Receptor Activity Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Cargo Receptor Activity Astrocyte Activation Involved In Immune Response Intermediate-density Lipoprotein Particle Positive Regulation Of Lysosomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process In The Vacuole Very-low-density Lipoprotein Particle Remodeling Triglyceride-rich Lipoprotein Particle Remodeling Regulation Of Cholesterol Transport Receptor Complex Regulation Of Lysosomal Protein Catabolic Process Low-density Lipoprotein Particle Hormone Binding Reverse Cholesterol Transport Protein-folding Chaperone Binding Heparan Sulfate Proteoglycan Binding Astrocyte Activation Response To Leptin Transcytosis Regulation Of Amyloid-beta Clearance Endosome Lumen Regulation Of Endocytosis Molecular Function Activator Activity Amyloid-beta Clearance Plasma Lipoprotein Particle Clearance Regulation Of Lipid Transport Amyloid Fibril Formation Lipoprotein Metabolic Process Plasma Lipoprotein Particle Remodeling Positive Regulation Of Endocytosis Positive Regulation Of Cholesterol Transport Protein-containing Complex Remodeling Negative Regulation Of Wnt Signaling Pathway Receptor-mediated Endocytosis Triglyceride Homeostasis Acylglycerol Homeostasis Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Endocytosis Regulation Of Cholesterol Efflux TMEM240-body Positive Regulation Of Transcytosis Alpha-2 Macroglobulin Receptor Activity
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