LPL and LUC7L2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		LPL	LUC7L2
Gene Name		lipoprotein lipase	LUC7-like 2 (S. cerevisiae)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Extracellular Matrix Anchored Component Of Membrane Very-low-density Lipoprotein Particle Chylomicron Extracellular Vesicular Exosome	U1 SnRNP Nuclear Speck
	Molecular Function	Lipoprotein Lipase Activity Phospholipase Activity Triglyceride Lipase Activity Receptor Binding Protein Binding Heparin Binding Triglyceride Binding Apolipoprotein Binding	MRNA Binding Protein Binding Enzyme Binding Poly(A) RNA Binding
	Biological Process	Retinoid Metabolic Process Fatty Acid Biosynthetic Process Triglyceride Metabolic Process Phospholipid Metabolic Process Phototransduction, Visible Light Response To Cold Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Storage Positive Regulation Of Sequestering Of Triglyceride Triglyceride Biosynthetic Process Triglyceride Catabolic Process Chylomicron Remodeling Very-low-density Lipoprotein Particle Remodeling Lipoprotein Metabolic Process Response To Drug Small Molecule Metabolic Process Triglyceride Homeostasis	MRNA Splice Site Selection
Pathways		Lipoprotein metabolism Visual phototransduction Metabolism of lipids and lipoproteins Chylomicron-mediated lipid transport Transcriptional regulation of white adipocyte differentiation Lipid digestion, mobilization, and transport Diseases associated with visual transduction Retinoid metabolism and transport
Drugs		Tyloxapol
Diseases
GWAS		Cardiovascular disease risk factors ( 21943158) HDL cholesterol ( 23726366 20031538 21909109 18193043 18193044 20864672 19060906 19060911 20686565) HDL Cholesterol - Triglycerides (HDLC-TG) ( 21386085) Hematological and biochemical traits ( 20139978) Hyperactive-impulsive symptoms ( 18821565) Hypertriglyceridemia ( 23505323 20657596) Lipid metabolism phenotypes ( 22286219 19936222) Metabolic syndrome ( 22399527 21386085 20694148) Metabolic syndrome (bivariate traits) ( 21386085) Metabolic traits ( 19060910) Metabolite levels ( 22916037) Triglycerides ( 23726366 21909109 18193043 18193044 18193046 20864672 19060906 19060911 22171074 20139978 17463246 20686565) Triglycerides-Blood Pressure (TG-BP) ( 21386085) Waist circumference and related phenotypes ( 18454146)
Protein-Protein Interactions		16 interactors: APOC2 APP ASCC2 CALR CCND1 CETP COPS6 EMD KIAA1377 LRP1 LRP2 LUC7L2 PTPN4 RPL18A UBE2Z VLDLR	54 interactors: AIMP2 ALB APP APPBP2 ATF7IP ATRX CADPS CCDC53 CDC37 CDK4 CDK5RAP2 CHD3 EXOC1 FAM173A FXR1 GADD45G GSK3B HAP1 HDHD2 IKBKG KIAA1377 KLHL20 LINC00341 LPL MAN2A2 MAP1LC3B NAP1L5 NASP NAT9 NDEL1 NDUFA4L2 NEDD4 NFYA NKAP NSF NUTF2 OFD1 PDPK1 PEA15 PIK3R3 PTCD3 PTN SAT1 SETDB1 SRPK1 SRPK2 SRSF6 SRSF7 SSFA2 SVIL ULK2 UNC119 YWHAG ZCCHC10
Entrez ID		4023	51631
HPRD ID		01999	17456
Ensembl ID		ENSG00000175445	ENSG00000146963
Uniprot IDs		P06858	Q9Y383
PDB IDs
Enriched GO Terms of Interacting Partners?		Steroid Metabolic Process Cholesterol Metabolic Process Sterol Metabolic Process Response To Light Stimulus Regulation Of Cholesterol Transport Alcohol Metabolic Process Receptor-mediated Endocytosis Endocytosis Response To Radiation Regulation Of Plasma Lipoprotein Particle Levels Very-low-density Lipoprotein Particle Remodeling Phototransduction, Visible Light Retinoid Metabolic Process Triglyceride-rich Lipoprotein Particle Remodeling Diterpenoid Metabolic Process Detection Of Visible Light Regulation Of Lipid Transport Phototransduction Detection Of Light Stimulus Reverse Cholesterol Transport Isoprenoid Metabolic Process Regulation Of Cholesterol Efflux Lipid Metabolic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Metabolic Process Plasma Lipoprotein Particle Remodeling Lipoprotein Metabolic Process Detection Of Abiotic Stimulus Vesicle-mediated Transport Triglyceride Homeostasis Plasma Lipoprotein Particle Clearance Acylglycerol Homeostasis Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Response To Abiotic Stimulus Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Peptide Antigen Assembly With MHC Class I Protein Complex Beta-amyloid Clearance Positive Regulation Of Cell Cycle Cholesterol Transport Sterol Transport Lipid Transport Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Differentiation Regulation Of Protein Kinase Activity Lipid Localization Cholesterol Homeostasis Sterol Homeostasis Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling	Organelle Organization Establishment Of Localization In Cell Cellular Localization Protein Transport Regulation Of Kinase Activity Establishment Of Protein Localization Cell Cycle Process Anatomical Structure Development Intracellular Transport Cell Cycle Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Metabolic Process Developmental Process Regulation Of Protein Kinase Activity Cellular Component Assembly Positive Regulation Of Cell Cycle Regulation Of MRNA Processing Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Development Regulation Of Cell Differentiation Multicellular Organismal Development Regulation Of RNA Splicing Exocytosis Regulation Of Protein Metabolic Process Regulation Of Neurogenesis Establishment Of Cell Polarity Protein Localization Chromatin Organization Retrograde Axon Cargo Transport Regulation Of Cell Cycle Positive Regulation Of Cell Cycle Process Regulation Of Neuron Differentiation Nuclear Export Mitotic Cell Cycle Regulation Of Cell Size Apoptotic Process Axon Cargo Transport Programmed Cell Death Chromosome Organization Organelle Localization Regulation Of Cellular Process Regulation Of Cell Death Positive Regulation Of Mitotic Cell Cycle Phase Transition Cell Death Positive Regulation Of Metabolic Process Death Regulation Of Phosphorylation Positive Regulation Of Cell Cycle Phase Transition Regulation Of Protein Phosphorylation Regulation Of Gene Expression
Tagcloud ?		8p21 apolipoprotein assigned atherosclerosis c5 c9 characterizing cli clones clusterin complement consider cosmid cytolytic determining glycoprotein isolating kb lipase lipoprotein nicked overlapping secreted seminal sertoli spans subchromosomal symbol translationally	add african alleles americans ankrd17 antihypertensive caucasian caucasians connections cox18 displaying diuretics elevations fto grin3a hctz heterozygotes hydrochlorothiazide hyperuricaemia padi4 pard3b pear pharmacogenomic replicated rs4784333 suggestive thiazide ua uric
Tagcloud (Difference) ?		8p21 apolipoprotein assigned atherosclerosis c5 c9 characterizing cli clones clusterin complement consider cosmid cytolytic determining glycoprotein isolating kb lipase lipoprotein nicked overlapping secreted seminal sertoli spans subchromosomal symbol translationally	add african alleles americans ankrd17 antihypertensive caucasian caucasians connections cox18 displaying diuretics elevations fto grin3a hctz heterozygotes hydrochlorothiazide hyperuricaemia padi4 pard3b pear pharmacogenomic replicated rs4784333 suggestive thiazide ua uric
Tagcloud (Intersection) ?