LPL and PTPN4

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		LPL	PTPN4
Gene Name		lipoprotein lipase	protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Extracellular Matrix Anchored Component Of Membrane Very-low-density Lipoprotein Particle Chylomicron Extracellular Vesicular Exosome	Cytoplasm Cytoskeleton Cytoplasmic Side Of Plasma Membrane
	Molecular Function	Lipoprotein Lipase Activity Phospholipase Activity Triglyceride Lipase Activity Receptor Binding Protein Binding Heparin Binding Triglyceride Binding Apolipoprotein Binding	Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding Cytoskeletal Protein Binding
	Biological Process	Retinoid Metabolic Process Fatty Acid Biosynthetic Process Triglyceride Metabolic Process Phospholipid Metabolic Process Phototransduction, Visible Light Response To Cold Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Storage Positive Regulation Of Sequestering Of Triglyceride Triglyceride Biosynthetic Process Triglyceride Catabolic Process Chylomicron Remodeling Very-low-density Lipoprotein Particle Remodeling Lipoprotein Metabolic Process Response To Drug Small Molecule Metabolic Process Triglyceride Homeostasis	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation
Pathways		Lipoprotein metabolism Visual phototransduction Metabolism of lipids and lipoproteins Chylomicron-mediated lipid transport Transcriptional regulation of white adipocyte differentiation Lipid digestion, mobilization, and transport Diseases associated with visual transduction Retinoid metabolism and transport
Drugs		Tyloxapol	Alendronate
Diseases
GWAS		Cardiovascular disease risk factors ( 21943158) HDL cholesterol ( 23726366 20031538 21909109 18193043 18193044 20864672 19060906 19060911 20686565) HDL Cholesterol - Triglycerides (HDLC-TG) ( 21386085) Hematological and biochemical traits ( 20139978) Hyperactive-impulsive symptoms ( 18821565) Hypertriglyceridemia ( 23505323 20657596) Lipid metabolism phenotypes ( 22286219 19936222) Metabolic syndrome ( 22399527 21386085 20694148) Metabolic syndrome (bivariate traits) ( 21386085) Metabolic traits ( 19060910) Metabolite levels ( 22916037) Triglycerides ( 23726366 21909109 18193043 18193044 18193046 20864672 19060906 19060911 22171074 20139978 17463246 20686565) Triglycerides-Blood Pressure (TG-BP) ( 21386085) Waist circumference and related phenotypes ( 18454146)
Protein-Protein Interactions		16 interactors: APOC2 APP ASCC2 CALR CCND1 CETP COPS6 EMD KIAA1377 LRP1 LRP2 LUC7L2 PTPN4 RPL18A UBE2Z VLDLR	11 interactors: ATRX CRK EEF1A1 EEF1G GRID2 GRIN2A KAT5 LPL PRSS1 TK1 ZZEF1
Entrez ID		4023	5775
HPRD ID		01999	01471
Ensembl ID		ENSG00000175445	ENSG00000088179
Uniprot IDs		P06858	P29074
PDB IDs			2CS5 2I75 2VPH 3NFK 3NFL
Enriched GO Terms of Interacting Partners?		Steroid Metabolic Process Cholesterol Metabolic Process Sterol Metabolic Process Response To Light Stimulus Regulation Of Cholesterol Transport Alcohol Metabolic Process Receptor-mediated Endocytosis Endocytosis Response To Radiation Regulation Of Plasma Lipoprotein Particle Levels Very-low-density Lipoprotein Particle Remodeling Phototransduction, Visible Light Retinoid Metabolic Process Triglyceride-rich Lipoprotein Particle Remodeling Diterpenoid Metabolic Process Detection Of Visible Light Regulation Of Lipid Transport Phototransduction Detection Of Light Stimulus Reverse Cholesterol Transport Isoprenoid Metabolic Process Regulation Of Cholesterol Efflux Lipid Metabolic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Metabolic Process Plasma Lipoprotein Particle Remodeling Lipoprotein Metabolic Process Detection Of Abiotic Stimulus Vesicle-mediated Transport Triglyceride Homeostasis Plasma Lipoprotein Particle Clearance Acylglycerol Homeostasis Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Response To Abiotic Stimulus Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Peptide Antigen Assembly With MHC Class I Protein Complex Beta-amyloid Clearance Positive Regulation Of Cell Cycle Cholesterol Transport Sterol Transport Lipid Transport Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Differentiation Regulation Of Protein Kinase Activity Lipid Localization Cholesterol Homeostasis Sterol Homeostasis Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling	Startle Response Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Response To Organic Substance Glutamate Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Regulation Of Excitatory Postsynaptic Membrane Potential Fetal Process Involved In Parturition Negative Regulation Of Telomeric RNA Transcription From RNA Pol II Promoter Regulation Of Postsynaptic Membrane Potential Response To External Stimulus Response To Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Signal Transduction In Response To DNA Damage Response To Radiation Skeletal Muscle Cell Proliferation Signal Transduction By P53 Class Mediator Membrane Depolarization Chylomicron Remodeling Cellular Response To Hydroxyurea Neuromuscular Process Directional Locomotion Positive Regulation Of Nuclear Cell Cycle DNA Replication Translational Elongation Response To Cortisol Thymidine Metabolic Process Positive Regulation Of Sequestering Of Triglyceride Deoxyribonucleoside Monophosphate Biosynthetic Process Very-low-density Lipoprotein Particle Remodeling Pyrimidine Nucleoside Salvage Pyrimidine-containing Compound Salvage Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Telomere Maintenance Triglyceride-rich Lipoprotein Particle Remodeling Cerebellar Granule Cell Differentiation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Regulation Of Membrane Potential DNA Damage Response, Signal Transduction Resulting In Transcription Response To Hormone Heterocycle Metabolic Process Prepulse Inhibition Serotonin Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To Stimulus Biosynthetic Process Replication Fork Processing Sleep Positive Regulation Of DNA-dependent DNA Replication Cerebellar Granular Layer Morphogenesis Parturition
Tagcloud ?		8p21 apolipoprotein assigned atherosclerosis c5 c9 characterizing cli clones clusterin complement consider cosmid cytolytic determining glycoprotein isolating kb lipase lipoprotein nicked overlapping secreted seminal sertoli spans subchromosomal symbol translationally	abrogates adopts analytical angle catalytic communication compact competence conformation disrupting emerging encompassing interdomain mere nmr notion pdz phosphatase physiologically players predominant prevents ray regulators restores scattering strengthens triggers ultracentrifugation
Tagcloud (Difference) ?		8p21 apolipoprotein assigned atherosclerosis c5 c9 characterizing cli clones clusterin complement consider cosmid cytolytic determining glycoprotein isolating kb lipase lipoprotein nicked overlapping secreted seminal sertoli spans subchromosomal symbol translationally	abrogates adopts analytical angle catalytic communication compact competence conformation disrupting emerging encompassing interdomain mere nmr notion pdz phosphatase physiologically players predominant prevents ray regulators restores scattering strengthens triggers ultracentrifugation
Tagcloud (Intersection) ?