GMEB1 and TRIM63

Number of citations of the paper that reports this interaction (PMID 11927605)
45

Data Source:
BioGRID (two hybrid)
HPRD (in vitro)

		GMEB1	TRIM63
Gene Name		glucocorticoid modulatory element binding protein 1	tripartite motif containing 63, E3 ubiquitin protein ligase
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Nucleus Cytoplasm Microtubule Z Disc M Band
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Metal Ion Binding	Ubiquitin-protein Transferase Activity Signal Transducer Activity Protein Binding Zinc Ion Binding Ligase Activity Titin Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated	Muscle Contraction Signal Transduction Regulation Of Gene Expression Skeletal Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Interleukin-1 Cellular Response To Dexamethasone Stimulus
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: ATF7IP CASP8 CASP9 CREBBP GMEB2 NCOA2 SMAD1 SMAD3 SNIP1 TRIM55 TRIM63 UBE2I	87 interactors: ACTA1 AK1 AKR7A2 ALDOA ANKRD1 APP ATP5B ATXN3 ATXN3L BAP1 CKB CKM DCAF6 DES EEF1G EHHADH EIF3E ENO3 ESPL1 FHL2 FLNC GFM1 GMEB1 HIBADH JOSD1 LMCD1 MRPL19 MRPL41 MYBPC1 MYBPC3 MYL2 MYOT MYOZ1 NDUFA1 NEB NEBL NOMO1 NRAP OTUB1 OTUB2 PDHB PDK4 PIAS1 PIAS2 PIAS3 PKM PSMD4 PYGM SENP2 SENP3 SQSTM1 SRF STAM SUMO2 TCAP TNNC1 TNNI1 TNNI2 TNNI3 TNNT1 TNNT3 TRIM54 TRIM55 TTN UBC UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2J1 UBE2U UCHL1 UCHL3 UCHL5 UQCRC1 USP13 USP15 USP2 USP21 USP28 USP33 USP4 USP5 USP7 USP8 UXT YOD1
Entrez ID		10691	84676
HPRD ID		16059	05843
Ensembl ID		ENSG00000162419	ENSG00000158022
Uniprot IDs		B1AT47 B2RCN8 Q9Y692	B4DN95 Q969Q1
PDB IDs		1OQJ	2D8U 3DDT
Enriched GO Terms of Interacting Partners?		Cellular Response To Organic Cyclic Compound Production Of MiRNAs Involved In Gene Silencing By MiRNA Gene Silencing By MiRNA Cellular Response To DsRNA Negative Regulation Of Gene Expression Posttranscriptional Gene Silencing Response To Organic Cyclic Compound Regulation Of Gene Expression, Epigenetic Primary MiRNA Processing Gene Silencing By RNA Viral Process SMAD Protein Complex Assembly Response To DsRNA Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To Organic Substance Activation Of Cysteine-type Endopeptidase Activity Response To Cobalt Ion Zymogen Activation Gene Silencing Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Metabolic Process Positive Regulation Of Endopeptidase Activity Positive Regulation Of Peptidase Activity Positive Regulation Of Metabolic Process Response To Organic Substance Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Cellular Response To Dexamethasone Stimulus Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Transcription, DNA-templated Response To Abiotic Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To Dexamethasone Signal Transduction Positive Regulation Of Cartilage Development Protein Processing Embryonic Morphogenesis Signaling Peptidyl-lysine Modification Regulation Of Cellular Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Transcription, DNA-templated Cell Communication Regulation Of RNA Biosynthetic Process	Protein Modification By Small Protein Removal Muscle Filament Sliding Actin-myosin Filament Sliding Protein Deubiquitination Actin-mediated Cell Contraction Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Actin Filament-based Movement Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein K48-linked Deubiquitination Proteolysis Muscle Contraction Regulation Of Proteasomal Protein Catabolic Process Catabolic Process Muscle System Process Regulation Of Protein Catabolic Process Actin Filament-based Process Protein K63-linked Deubiquitination Striated Muscle Cell Development Striated Muscle Contraction Muscle Cell Development Muscle Structure Development Myofibril Assembly Cellular Protein Modification Process Cellular Protein Metabolic Process Regulation Of Proteolysis Cardiac Muscle Tissue Morphogenesis Striated Muscle Cell Differentiation Muscle Tissue Morphogenesis Cardiac Muscle Tissue Development Muscle Organ Morphogenesis Actomyosin Structure Organization Protein Sumoylation Protein Metabolic Process Striated Muscle Tissue Development Muscle Cell Differentiation Muscle Tissue Development Regulation Of Muscle Contraction Protein Modification By Small Protein Conjugation Muscle Organ Development Heart Morphogenesis Regulation Of Cellular Protein Metabolic Process Cardiac Myofibril Assembly Muscle Fiber Development Monoubiquitinated Protein Deubiquitination
Tagcloud ?			benzylic bioactivation clues covalent danger dapk1 hapten hepatotoxicity il22 inflammasome marks methide nevirapine nlrp3 nvp obligate oh oxidized presumably quinone ra2 rash rashes reflecting s100a7 s100a7a sulfate travels
Tagcloud (Difference) ?			benzylic bioactivation clues covalent danger dapk1 hapten hepatotoxicity il22 inflammasome marks methide nevirapine nlrp3 nvp obligate oh oxidized presumably quinone ra2 rash rashes reflecting s100a7 s100a7a sulfate travels
Tagcloud (Intersection) ?