GMEB1 and CASP9

Number of citations of the paper that reports this interaction (PubMedID 16497673)
0

Data Source:
HPRD (in vivo, two hybrid)

		GMEB1	CASP9
Description		glucocorticoid modulatory element binding protein 1	caspase 9
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm	Nucleus Cytoplasm Mitochondrion Cytosol Caspase Complex Protein-containing Complex Apoptosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding Hsp27 Protein Binding Sequence-specific Double-stranded DNA Binding	Cysteine-type Endopeptidase Activity Protein Binding Enzyme Activator Activity Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Protein Kinase Binding Identical Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II	Response To Hypoxia Kidney Development Response To Ischemia Proteolysis Apoptotic Process DNA Damage Response Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To UV Protein Processing Platelet Formation Response To Cobalt Ion Response To Estradiol Response To Lipopolysaccharide Glial Cell Apoptotic Process Cellular Response To UV Signal Transduction In Response To DNA Damage Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Fibroblast Apoptotic Process Neuron Apoptotic Process Protein Maturation Cellular Response To Dexamethasone Stimulus Response To Indole-3-methanol Leukocyte Apoptotic Process Response To Anesthetic Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Execution Phase Of Apoptosis Epithelial Cell Apoptotic Process
Pathways			Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes NOD1/2 Signaling Pathway AKT phosphorylates targets in the cytosol Caspase activation via Dependence Receptors in the absence of ligand Constitutive Signaling by AKT1 E17K in Cancer Regulation of the apoptosome activity Regulation of the apoptosome activity
Drugs			Pamidronic acid
Diseases
GWAS		Basophil count ( 32888494)	Alcoholic chronic pancreatitis ( 28754779) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate (creatinine) ( 26831199 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Orofacial cleft x maternal periconceptional multivitamin use interaction (1df) ( 33937227) Orofacial cleft x maternal periconceptional multivitamin use interaction (2df) ( 33937227) Serum metabolite levels ( 33031748) Urate levels ( 31578528) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		16 interacting genes: ATF7IP CASP8 CASP9 CREBBP DNMT3L GMEB2 MX1 NCOA2 RAD51 SMAD1 SMAD3 SNIP1 SPOP TRIM55 TRIM63 UBE2I	47 interacting genes: ABL1 AKT1 APAF1 ARNT BCL10 BCL2L1 BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 BIRC8 CAPN2 CARD8 CASP10 CASP12 CASP3 CASP7 CASP8 CYCS DCC DIABLO DSP GMEB1 GZMB HECTD3 HIP1 HSD17B4 HSPD1 ILK JUN LYN MAP2K1 MAP2K2 MAPK1 MAPK3 MSTO1 MZB1 NAIP NLRP1 NOD1 PRKCZ RB1 RNF2 SRF VIM XIAP
Entrez ID		10691	842
HPRD ID		16059	03756
Ensembl ID		ENSG00000162419	ENSG00000132906
Uniprot IDs		B1AT47 B2RCN8 Q9Y692	F8VVS7 P55211
PDB IDs		1OQJ	1JXQ 1NW9 2AR9 3D9T 3V3K 3YGS 4RHW 5JUY 5WVC 5WVE
Enriched GO Terms of Interacting Partners?		Nucleus Transcription Regulator Complex MiRNA Processing Response To Anesthetic Identical Protein Binding Nuclear Receptor Binding Heteromeric SMAD Protein Complex SMAD Protein Complex DEAD/H-box RNA Helicase Binding Response To Cobalt Ion Chromatin Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Co-SMAD Binding Primary MiRNA Processing Regulation Of Metabolic Process I-SMAD Binding Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Execution Phase Of Apoptosis Ubiquitin Protein Ligase Binding Regulation Of Macromolecule Metabolic Process Transcription Coregulator Activity SMAD Protein Signal Transduction Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Double-strand Break Repair Nuclear Body Positive Regulation Of Cartilage Development Enzyme Binding Cytoplasm Cellular Response To Radiation DNA Methylation-dependent Constitutive Heterochromatin Formation Negative Regulation Of Cardiac Muscle Hypertrophy Protein-containing Complex Ureteric Bud Development Negative Regulation Of Muscle Hypertrophy Meiosis I Transcription Regulator Inhibitor Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Response To External Biotic Stimulus Cytosol Caspase Complex Response To Steroid Hormone Post-translational Protein Modification Chromatin Binding Negative Regulation Of DNA-templated Transcription Transcription Coactivator Binding Negative Regulation Of RNA Biosynthetic Process Mesonephric Epithelium Development Mesonephric Tubule Development	Programmed Cell Death Cell Death Apoptotic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Regulation Of Cell Communication Regulation Of Signaling Execution Phase Of Apoptosis Positive Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Regulation Of Signal Transduction Cytoplasm Regulation Of Defense Response Regulation Of Inflammatory Response Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Programmed Cell Death Positive Regulation Of Defense Response Neuron Apoptotic Process Pyroptotic Inflammatory Response Bergmann Glial Cell Differentiation Regulation Of Golgi Inheritance Negative Regulation Of Apoptotic Process Cytosol Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Immune System Process Regulation Of Immune Response Cysteine-type Endopeptidase Inhibitor Activity Glial Cell Development Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Immune System Process Regulation Of Macromolecule Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Signaling Pathway Regulation Of Protein Modification Process Schwann Cell Development Regulation Of Neuron Apoptotic Process Trachea Formation Response To Lipid Regulation Of Innate Immune Response Regulation Of Metabolic Process Face Development Positive Regulation Of Biosynthetic Process Thymus Development
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