NXF1 and NME1

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		NXF1	NME1
Description		nuclear RNA export factor 1	NME/NM23 nucleoside diphosphate kinase 1
Image
GO Annotations	Cellular Component	Transcription Export Complex Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Cytosol Cytoplasmic Stress Granule Nuclear Speck Nuclear RNA Export Factor Complex Nuclear Inclusion Body	Nucleus Cytoplasm Early Endosome Cytosol Membrane Ruffle Membrane Extracellular Exosome
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding	Nucleotide Binding Magnesium Ion Binding DNA Binding RNA Binding DNA Endonuclease Activity DNA Nuclease Activity Nucleoside Diphosphate Kinase Activity Protein Histidine Kinase Activity Protein Binding ATP Binding 3'-5'-DNA Exonuclease Activity Kinase Activity Transferase Activity Phosphotransferase Activity, Phosphate Group As Acceptor GDP Binding Identical Protein Binding Ribosomal Small Subunit Binding ADP Binding Metal Ion Binding Farnesyl Diphosphate Kinase Activity Coenzyme A Binding Succinyl-CoA Binding Acetyl-CoA Binding
	Biological Process	RNA Export From Nucleus MRNA Export From Nucleus Protein Transport Poly(A)+ MRNA Export From Nucleus MRNA Transport	GTP Biosynthetic Process UTP Biosynthetic Process CTP Biosynthetic Process DNA Catabolic Process Apoptotic DNA Fragmentation Isoprenoid Metabolic Process Endocytosis Nervous System Development Lactation Negative Regulation Of Cell Population Proliferation Nucleotide Metabolic Process Nucleoside Diphosphate Metabolic Process Nucleoside Triphosphate Biosynthetic Process Cell Differentiation Mammary Gland Development Protein Hexamerization Regulation Of Fatty Acid Biosynthetic Process Regulation Of Apoptotic Process ITP Biosynthetic Process Acetyl-CoA Catabolic Process Positive Regulation Of Epithelial Cell Proliferation
Pathways		Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript	Interconversion of nucleotide di- and triphosphates Azathioprine ADME Ribavirin ADME
Drugs			Zinc 2'-Deoxyguanosine-5'-Triphosphate Selenocysteine 2',3'-Dehydro-2',3'-Deoxy-Thymidine 5'-Diphosphate Adenosine Phosphonoacetic Acid Stavudine triphosphate Thymidine-5'- Diphosphate 2'-Deoxyguanosine-5'-Diphosphate 2',3'-dideoxy-3'-fluoro-urididine-5'-diphosphate Guanosine-5'-Diphosphate 3'-Deoxy 3'-Amino Adenosine-5'-Diphosphate Zidovudine diphosphate Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Bipolar disorder ( 31043756) Conjunctival UV autofluorescence (CUVAF) ( 25590795) Metabolite levels ( 23823483)
Interacting Genes		138 interacting genes: ALDOA ALYREF APOBEC3C AUNIP BACH2 BECN1 BICD2 BIN3 BIRC2 BLMH BTBD18 C10orf55 C1orf35 CAMK2G CCDC120 CCDC196 CCDC197 CCDC7 CDYL2 CEBPA CEP55 CLK2 CLK3 CPSF7 CSNK2A1 CTTN DDX50 DHX9 DMRTB1 DVL3 ECSIT EIF4A3 ELAVL4 ESRRA EXOSC8 FAM9A FTO GFAP GOLGA6L9 GPBP1 GTPBP2 HNRNPUL1 HOMEZ HOXA1 HSF2BP IMPA1 IPO11 IPO4 ISY1-RAB43 KATNBL1 KCTD5 KCTD7 KIF24 KRT31 KRT40 LCE3E LDOC1 LUZP4 MAGOH MAP1A MAP1B MBD3L1 MID2 MRNIP MTUS2 NKAPD1 NME1 NME4 NUP153 NUP214 NUP62 NUP98 NXF2 NXF3 NXF5 NXT1 NXT2 PEG10 PIH1D2 PPP1R12C PRKAR1B PRPH PRR3 PRRC2B PURB QKI RAD51 RAE1 RALYL RAN RANBP2 RBFOX2 RBM15B RBM22 RBMX RBPMS REDIC1 RPRD1A SGTA SH2D3A SH3GLB2 SLAIN1 SNRPA SNW1 SPATC1L SRPK2 SRSF1 SRSF3 SRSF4 SRSF7 SRSF8 STRAP SYCP3 TBC1D14 TCP10L TEX9 TFIP11 THOC5 TIFA TNFAIP1 TNPO1 TNPO2 TRA2A TRA2B U2AF1 UBQLN1 UBQLN4 UPF3A VAPA VIM VPS28 WEE2-AS1 XIST ZBED2 ZC3HAV1 ZNF250 ZNF343 ZNF438	35 interacting genes: APEX1 AURKA CCND3 DDX19A FBXO24 FXR1 FXR2 GORASP2 ITGB1 KSR1 LNX1 MIF NIF3L1 NME3 NME4 NTAQ1 NUTF2 NXF1 PID1 POLR1C PRPF6 PRUNE1 RAC1 RORA RORB RRAD SET SMARCD1 SNCA SOX30 SREK1IP1 TERF1 TIAM1 TNPO2 TNPO3
Entrez ID		10482	4830
HPRD ID		04035	01131
Ensembl ID		ENSG00000162231	ENSG00000239672
Uniprot IDs		Q59E96 Q9UBU9	A0A384MTW7 P15531
PDB IDs		1FO1 1FT8 1GO5 1JKG 1JN5 1KOH 1KOO 1OAI 2Z5K 2Z5M 3RW6 3RW7 4WYK 6E5U	1JXV 1UCN 2HVD 2HVE 3L7U 4ENO 5UI4 8OOV
Enriched GO Terms of Interacting Partners?		MRNA Transport RNA Transport Nucleobase-containing Compound Transport RNA Binding RNA Export From Nucleus MRNA Binding Nuclear Transport Nucleocytoplasmic Transport Nuclear Export Regulation Of MRNA Splicing, Via Spliceosome Regulation Of RNA Splicing Regulation Of MRNA Processing MRNA Metabolic Process RNA Splicing MRNA Processing Regulation Of MRNA Metabolic Process MRNA Export From Nucleus Nucleic Acid Binding RNA Processing Nucleus Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Metabolic Process RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome Intracellular Transport Nucleic Acid Metabolic Process Nuclear RNA Export Factor Complex Nucleoplasm Positive Regulation Of RNA Splicing Identical Protein Binding Import Into Nucleus Protein Binding Cellular Localization Nuclear Localization Sequence Binding Nuclear Pore Spliceosomal Complex Catalytic Step 2 Spliceosome Protein Import Into Nucleus Nucleobase-containing Compound Metabolic Process Nuclear Speck Positive Regulation Of MRNA Splicing, Via Spliceosome Establishment Of Localization In Cell Protein Localization To Nucleus Exon-exon Junction Complex Establishment Of Protein Localization To Organelle Poly(A)+ MRNA Export From Nucleus Protein Localization To Organelle Nuclear Envelope Intracellular Protein Transport Negative Regulation Of MRNA Metabolic Process	Mitochondrion-mitochondrion Outer Membrane Tether Activity Regulation Of Neuronal Synaptic Plasticity Regulation Of Translation At Presynapse, Modulating Synaptic Transmission MRNA Transport RNA Transport Nuclear Import Signal Receptor Activity Regulation Of Long-term Neuronal Synaptic Plasticity Cytoplasmic Stress Granule Cytoplasm Nucleobase-containing Compound Transport Negative Regulation Of Biosynthetic Process Postsynapse Double-stranded Telomeric DNA Binding Cellular Component Assembly UTP Biosynthetic Process GTP Biosynthetic Process UTP Metabolic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Nuclear Transport Nucleocytoplasmic Transport Regulation Of Cell Differentiation Central Nervous System Neuron Differentiation Protein Hexamerization Protein Binding Regulation Of Cell Development Regulation Of Macrophage Activation Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Development CTP Biosynthetic Process CTP Metabolic Process Regulation Of Microtubule Polymerization Protein-containing Complex Organization Nucleoside Diphosphate Kinase Activity Regulation Of Hydrogen Peroxide Metabolic Process Nucleus Translation Regulator Activity Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Cytoplasmic Ribonucleoprotein Granule Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Neurotransmitter Uptake Neuron Differentiation Protein-containing Complex Assembly Regulation Of Synaptic Plasticity Nucleosome Disassembly Regulation Of Rho Protein Signal Transduction Regulation Of Neurogenesis GTP Metabolic Process Regulation Of Cell Maturation Protein-DNA Complex Disassembly
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