NME1 and RRAD

Number of citations of the paper that reports this interaction (PMID 11280768)
20

Data Source:
HPRD (in vitro, in vivo)

		NME1	RRAD
Gene Name		NME/NM23 nucleoside diphosphate kinase 1	Ras-related associated with diabetes
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Membrane Ruffle Membrane Extracellular Vesicular Exosome	Plasma Membrane
	Molecular Function	Magnesium Ion Binding Deoxyribonuclease Activity Nucleoside Diphosphate Kinase Activity Protein Binding ATP Binding GTP Binding Identical Protein Binding Ribosomal Small Subunit Binding Poly(A) RNA Binding	GTPase Activity Protein Binding Calmodulin Binding GTP Binding
	Biological Process	Purine Nucleotide Metabolic Process Nucleoside Diphosphate Phosphorylation GTP Biosynthetic Process Pyrimidine Nucleotide Metabolic Process UTP Biosynthetic Process CTP Biosynthetic Process DNA Catabolic Process Endocytosis Nervous System Development Negative Regulation Of Cell Proliferation Nucleoside Triphosphate Biosynthetic Process Nucleobase-containing Small Molecule Interconversion Cell Differentiation Regulation Of Apoptotic Process Positive Regulation Of DNA Binding Small Molecule Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Nucleobase-containing Small Molecule Metabolic Process	Small GTPase Mediated Signal Transduction
Pathways		Metabolism of nucleotides Synthesis and interconversion of nucleotide di- and triphosphates
Drugs
Diseases
GWAS
Protein-Protein Interactions		27 interactors: APEX1 AURKA CCND3 FXR2 GORASP2 ITGB1 KSR1 MIF NIF3L1 NME2 NME3 NME4 PID1 POLR1C PRUNE RAC1 RORA RORB RRAD SET SMARCD1 SOX30 SREK1IP1 TERF1 TIAM1 TNPO2 WDYHV1	11 interactors: CALM1 CAMK2G CSNK2A1 CSNK2B MMP14 NME1 PRKACA PRKCA PRKCB TPM2 YWHAZ
Entrez ID		4830	6236
HPRD ID		01131	01536
Ensembl ID		ENSG00000239672	ENSG00000166592
Uniprot IDs		P15531	P55042
PDB IDs		1JXV 1UCN 2HVD 2HVE 3L7U 4ENO	2DPX 2GJS 3Q72 3Q7P 3Q7Q
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Regulation Of Apoptotic Process GTP Biosynthetic Process UTP Biosynthetic Process GTP Metabolic Process UTP Metabolic Process Regulation Of Cell Death CTP Biosynthetic Process Positive Regulation Of Metabolic Process Nucleoside Diphosphate Phosphorylation Pyrimidine Ribonucleotide Biosynthetic Process Pyrimidine Nucleoside Biosynthetic Process Pyrimidine Nucleotide Biosynthetic Process Nucleotide Phosphorylation Nucleoside Diphosphate Metabolic Process Regulation Of Metabolic Process Response To Organic Cyclic Compound Pyrimidine Nucleoside Metabolic Process Regulation Of Cell Cycle Response To Hormone Pyrimidine Nucleotide Metabolic Process Cellular Response To Lipid Nucleoside Triphosphate Biosynthetic Process Nucleosome Disassembly Mitotic Cell Cycle Nucleobase-containing Small Molecule Interconversion Regulation Of Cell Cycle Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cell Development Response To Drug Positive Regulation Of Cell Projection Organization Response To Organic Substance Positive Regulation Of Cell Cycle Response To Lipid Ribonucleotide Metabolic Process Positive Regulation Of Mitotic Cell Cycle Purine Nucleotide Metabolic Process Ribose Phosphate Metabolic Process Regulation Of DNA Replication Regulation Of Macrophage Activation Regulation Of Protein Metabolic Process Cell Cycle Telomere Maintenance Via Telomere Lengthening Cellular Response To Organic Substance Purine Nucleotide Biosynthetic Process Cell-matrix Adhesion Ribose Phosphate Biosynthetic Process Cellular Response To Organic Cyclic Compound Regulation Of Cellular Component Organization Cellular Response To Acid Chemical	Histone H3-T6 Phosphorylation Phosphorylation Platelet Activation Negative Regulation Of Glucose Transport Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Dense Core Granule Biogenesis Regulation Of Rhodopsin Mediated Signaling Pathway Activation Of Adenylate Cyclase Activity Phosphate-containing Compound Metabolic Process Rhodopsin Mediated Signaling Pathway Mitotic Cell Cycle Positive Regulation Of Adenylate Cyclase Activity Mitotic Nuclear Envelope Disassembly Negative Regulation Of Insulin Receptor Signaling Pathway Blood Coagulation Hemostasis Nuclear Envelope Disassembly Histone Phosphorylation Regulation Of Blood Vessel Endothelial Cell Migration Peptidyl-threonine Phosphorylation Positive Regulation Of Lyase Activity Cell-cell Signaling Activation Of Phospholipase C Activity Regulation Of Adenylate Cyclase Activity Positive Regulation Of Phospholipase C Activity Positive Regulation Of CAMP Biosynthetic Process Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cyclase Activity Regulation Of Body Fluid Levels Nuclear Envelope Organization Positive Regulation Of CAMP Metabolic Process Synaptic Transmission Wound Healing Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Phospholipase Activity Cellular Response To Carbohydrate Stimulus Phototransduction, Visible Light Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Cyclic Nucleotide Metabolic Process Positive Regulation Of Protein Metabolic Process Cell Activation Regulation Of Phospholipase Activity Mitotic Cell Cycle Process Regulation Of CAMP Biosynthetic Process Positive Regulation Of Lipase Activity Positive Regulation Of Signal Transduction Detection Of Visible Light Response To Wounding Desmosome Assembly
Tagcloud ?		17q12 anonymous brca1 cloning colia1 d17s183 dinucleotide edh17b exclude excludes families heterozygosity hox2 inherited locale ngfr nme2 ovarian phb pinpoint polymorphisms positional q21 rara recombination resolving scg43 thra1 wnt3	abolishes antagonizing biosynthetic blocking contributes demands display drives ectopic energetic glut1 glycolysis greatly hypoxia hypoxic meet microenvironmental newly normoxia p53 promotes reduces represses repressing stimulating suppression switch translocation turn
Tagcloud (Difference) ?		17q12 anonymous brca1 cloning colia1 d17s183 dinucleotide edh17b exclude excludes families heterozygosity hox2 inherited locale ngfr nme2 ovarian phb pinpoint polymorphisms positional q21 rara recombination resolving scg43 thra1 wnt3	abolishes antagonizing biosynthetic blocking contributes demands display drives ectopic energetic glut1 glycolysis greatly hypoxia hypoxic meet microenvironmental newly normoxia p53 promotes reduces represses repressing stimulating suppression switch translocation turn
Tagcloud (Intersection) ?