NME1 and KSR1

Number of citations of the paper that reports this interaction (PMID 12105213)
29

Data Source:
HPRD (in vivo, in vitro)

		NME1	KSR1
Gene Name		NME/NM23 nucleoside diphosphate kinase 1	kinase suppressor of ras 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Membrane Ruffle Membrane Extracellular Vesicular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Magnesium Ion Binding Deoxyribonuclease Activity Nucleoside Diphosphate Kinase Activity Protein Binding ATP Binding GTP Binding Identical Protein Binding Ribosomal Small Subunit Binding Poly(A) RNA Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP-kinase Scaffold Activity Protein Binding ATP Binding Mitogen-activated Protein Kinase Kinase Binding Metal Ion Binding
	Biological Process	Purine Nucleotide Metabolic Process Nucleoside Diphosphate Phosphorylation GTP Biosynthetic Process Pyrimidine Nucleotide Metabolic Process UTP Biosynthetic Process CTP Biosynthetic Process DNA Catabolic Process Endocytosis Nervous System Development Negative Regulation Of Cell Proliferation Nucleoside Triphosphate Biosynthetic Process Nucleobase-containing Small Molecule Interconversion Cell Differentiation Regulation Of Apoptotic Process Positive Regulation Of DNA Binding Small Molecule Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Nucleobase-containing Small Molecule Metabolic Process	Protein Phosphorylation Ras Protein Signal Transduction Positive Regulation Of MAPK Cascade
Pathways		Metabolism of nucleotides Synthesis and interconversion of nucleotide di- and triphosphates
Drugs
Diseases
GWAS
Protein-Protein Interactions		27 interactors: APEX1 AURKA CCND3 FXR2 GORASP2 ITGB1 KSR1 MIF NIF3L1 NME2 NME3 NME4 PID1 POLR1C PRUNE RAC1 RORA RORB RRAD SET SMARCD1 SOX30 SREK1IP1 TERF1 TIAM1 TNPO2 WDYHV1	7 interactors: EPHB2 MAP2K1 MAPK1 MARK3 NME1 RAF1 YWHAZ
Entrez ID		4830	8844
HPRD ID		01131	18980
Ensembl ID		ENSG00000239672
Uniprot IDs		P15531	H7BYU0 Q8IVT5
PDB IDs		1JXV 1UCN 2HVD 2HVE 3L7U 4ENO
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Regulation Of Apoptotic Process GTP Biosynthetic Process UTP Biosynthetic Process GTP Metabolic Process UTP Metabolic Process Regulation Of Cell Death CTP Biosynthetic Process Positive Regulation Of Metabolic Process Nucleoside Diphosphate Phosphorylation Pyrimidine Ribonucleotide Biosynthetic Process Pyrimidine Nucleoside Biosynthetic Process Pyrimidine Nucleotide Biosynthetic Process Nucleotide Phosphorylation Nucleoside Diphosphate Metabolic Process Regulation Of Metabolic Process Response To Organic Cyclic Compound Pyrimidine Nucleoside Metabolic Process Regulation Of Cell Cycle Response To Hormone Pyrimidine Nucleotide Metabolic Process Cellular Response To Lipid Nucleoside Triphosphate Biosynthetic Process Nucleosome Disassembly Mitotic Cell Cycle Nucleobase-containing Small Molecule Interconversion Regulation Of Cell Cycle Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cell Development Response To Drug Positive Regulation Of Cell Projection Organization Response To Organic Substance Positive Regulation Of Cell Cycle Response To Lipid Ribonucleotide Metabolic Process Positive Regulation Of Mitotic Cell Cycle Purine Nucleotide Metabolic Process Ribose Phosphate Metabolic Process Regulation Of DNA Replication Regulation Of Macrophage Activation Regulation Of Protein Metabolic Process Cell Cycle Telomere Maintenance Via Telomere Lengthening Cellular Response To Organic Substance Purine Nucleotide Biosynthetic Process Cell-matrix Adhesion Ribose Phosphate Biosynthetic Process Cellular Response To Organic Cyclic Compound Regulation Of Cellular Component Organization Cellular Response To Acid Chemical	Phosphorylation Regulation Of Golgi Inheritance Phosphate-containing Compound Metabolic Process Activation Of MAPKK Activity Regulation Of Golgi Organization Golgi Inheritance Axon Guidance Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Early Endosome To Late Endosome Transport Axonogenesis Insulin Receptor Signaling Pathway Protein Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Axon Development Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Cellular Response To Fibroblast Growth Factor Stimulus Neuron Projection Morphogenesis Platelet Activation Response To Fibroblast Growth Factor Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Response To Wounding Ras Protein Signal Transduction Cell Morphogenesis Involved In Differentiation Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway MAPK Cascade Neuron Projection Development Fc Receptor Signaling Pathway Activation Of Protein Kinase Activity Cell Projection Morphogenesis Placenta Blood Vessel Development Signal Transduction By Phosphorylation Cell Part Morphogenesis Cardiovascular System Development Response To Insulin Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Component Organization Cellular Response To Peptide Hormone Stimulus Neuron Development Cellular Response To Peptide Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Labyrinthine Layer Development Toll-like Receptor TLR6:TLR2 Signaling Pathway
Tagcloud ?		17q12 anonymous brca1 cloning colia1 d17s183 dinucleotide edh17b exclude excludes families heterozygosity hox2 inherited locale ngfr nme2 ovarian phb pinpoint polymorphisms positional q21 rara recombination resolving scg43 thra1 wnt3	actors advance bc deregulation dfs disequilibrium doi eralpha igfr implication journal kinome lmtk3 multivariable october online pharmacogenomics publication rs1075952 rs224190 rs2241906 rs2293180 suppressors tam tc tpj tt undergone utr
Tagcloud (Difference) ?		17q12 anonymous brca1 cloning colia1 d17s183 dinucleotide edh17b exclude excludes families heterozygosity hox2 inherited locale ngfr nme2 ovarian phb pinpoint polymorphisms positional q21 rara recombination resolving scg43 thra1 wnt3	actors advance bc deregulation dfs disequilibrium doi eralpha igfr implication journal kinome lmtk3 multivariable october online pharmacogenomics publication rs1075952 rs224190 rs2241906 rs2293180 suppressors tam tc tpj tt undergone utr
Tagcloud (Intersection) ?